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Cellosaurus ES2/GFP (CVCL_E8YD)

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Cell line name ES2/GFP
Synonyms ES2 / GFP
Accession CVCL_E8YD
Resource Identification Initiative To cite this cell line use: ES2/GFP (RRID:CVCL_E8YD)
Comments Problematic cell line: Probably misclassified. Parent cell line seems to originate from a Caucasian patient with an ovarian serous adenocarcinoma origin.
Population: Caucasian.
Characteristics: Transduced by lentivirus with a EF1a-eGFP-Rsv-PuroR-WPRE construct (GenTarget=SC066-G).
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:26144; PALB2; Simple; p.Lys295_Met296insTer (c.886delA) (p.Met296Terfs); ClinVar=VCV000143979; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.242_243CC>TT (-138/-139CC>TT); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Homozygous (from parent cell line).
Disease Ovarian clear cell adenocarcinoma (NCIt: C40078)
Clear cell adenocarcinoma of the ovary (ORDO: Orphanet_398971)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3509 (ES-2)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Web pages Provider; GenTarget; SC066-G; https://www.gentarget.com/product/human-es2-gfp-stable-cells/
Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1