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Cellosaurus ES-2R (CVCL_M715)

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Cell line name ES-2R
Accession CVCL_M715
Resource Identification Initiative To cite this cell line use: ES-2R (RRID:CVCL_M715)
Comments Problematic cell line: Probably misclassified. Parent cell line seems to originate from a Caucasian patient with an ovarian serous adenocarcinoma origin.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_41576; 3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin (Cyanomorpholinoadriamycin; MRA-CN).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:26144; PALB2; Simple; p.Lys295_Met296insTer (c.886delA) (p.Met296Terfs); ClinVar=VCV000143979; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.242_243CC>TT (-138/-139CC>TT); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Homozygous (from parent cell line).
Disease Ovarian clear cell adenocarcinoma (NCIt: C40078)
Clear cell adenocarcinoma of the ovary (ORDO: Orphanet_398971)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3509 (ES-2)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Publications

PubMed=1717140
Derick H.M. Lau, Alexander D. Lewis, Mohamed N. Ehsan, Branimir Ivan Sikic;
Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin.
Cancer Res. 51:5181-5187(1991)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M715
Encyclopedic resources Wikidata; Q54832439
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number17