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Cellosaurus WiDr/R (CVCL_2N03)

[Text version]
Cell line name WiDr/R
Accession CVCL_2N03
Resource Identification Initiative To cite this cell line use: WiDr/R (RRID:CVCL_2N03)
Comments Problematic cell line: Contaminated. Parent cell line (WiDr) had been shown to be a HT-29 derivative.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2760 (WiDr)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

CLPUB00271
Wallace R.E., Lindh D., Durr F.E.
Studies on the development of resistance to mitoxantrone in human colon carcinoma cells in vitro.
Proc. Am. Assoc. Cancer Res. 23:195.767-195.767(1982)

PubMed=2894893
Dalton W.S., Cress A.E., Alberts D.S., Trent J.M.
Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone.
Cancer Res. 48:1882-1888(1988)

Cross-references
Cell line databases/resources cancercelllines; CVCL_2N03
Encyclopedic resources Wikidata; Q54994057
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number19