| Cell line name |
WiDr/R |
|---|
| Accession |
CVCL_2N03 |
|---|
| Resource Identification Initiative |
To cite this cell line use: WiDr/R (RRID:CVCL_2N03) |
|---|
| Comments |
Problematic cell line: Contaminated. Parent cell line (WiDr) had been shown to be a HT-29 derivative.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Colon adenocarcinoma (NCIt: C4349) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_2760 (WiDr) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
44Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | CLPUB00271
Roslyn Elizabeth Wallace, Delores Lindh, Frederick E. Durr;
Studies on the development of resistance to mitoxantrone in human colon carcinoma cells in vitro.
Proc. Am. Assoc. Cancer Res. 23:195.767-195.767(1982) PubMed=2894893
William S. Dalton, Anne Elizabeth Cress, David Samuel Alberts, Jeffrey M. Trent;
Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone.
Cancer Res. 48:1882-1888(1988) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_2N03
|
|---|
| Encyclopedic resources |
Wikidata; Q54994057
|
|---|
| Entry history |
|---|
| Entry creation | 14-Dec-2015 |
|---|
| Last entry update | 19-Dec-2024 |
|---|
| Version number | 19 |
|---|
