ID   WiDr/R
AC   CVCL_2N03
DR   cancercelllines; CVCL_2N03
DR   Wikidata; Q54994057
RX   CelloPub=CLPUB00271;
RX   PubMed=2894893;
CC   Problematic cell line: Contaminated. Parent cell line (WiDr) had been shown to be a HT-29 derivative.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2760 ! WiDr
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 18
//
RX   CelloPub=CLPUB00271;
RA   Wallace R.E., Lindh D., Durr F.E.;
RT   "Studies on the development of resistance to mitoxantrone in human
RT   colon carcinoma cells in vitro.";
RL   Proc. Am. Assoc. Cancer Res. 23:767-767(1982).
//
RX   PubMed=2894893;
RA   Dalton W.S., Cress A.E., Alberts D.S., Trent J.M.;
RT   "Cytogenetic and phenotypic analysis of a human colon carcinoma cell
RT   line resistant to mitoxantrone.";
RL   Cancer Res. 48:1882-1888(1988).
//