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Cellosaurus SRD-13A (CVCL_2H52)

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Cell line name SRD-13A
Synonyms SRD13A; Sterol Regulatory Defective-13A
Accession CVCL_2H52
Resource Identification Initiative To cite this cell line use: SRD-13A (RRID:CVCL_2H52)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:15455; MBTPS2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCIt; C129643; Cesium-137 gamma radiation.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_2H49 (CHO/pS2P)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=10497220; DOI=10.1074/jbc.274.40.28549
Robert B. Rawson, Russell A. DeBose-Boyd, Joseph Leonard Goldstein, Michael Stuart Brown;
Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.
J. Biol. Chem. 274:28549-28556(1999)

PubMed=12482938; DOI=10.1073/pnas.262669399; PMCID=PMC139202
Daisuke Yabe, Zong-Ping Xia, Christopher M. Adams, Robert B. Rawson;
Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.
Proc. Natl. Acad. Sci. U.S.A. 99:16672-16677(2002)

Cross-references
Encyclopedic resources Wikidata; Q54955658
Entry history
Entry creation22-Sep-2015
Last entry update14-Aug-2025
Version number11