ID   SRD-13A
AC   CVCL_2H52
SY   SRD13A; Sterol Regulatory Defective-13A
DR   Wikidata; Q54955658
RX   PubMed=10497220;
RX   PubMed=12482938;
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:15455; MBTPS2.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Transformant: NCIt; C129643; Cesium-137 gamma radiation.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_2H49 ! CHO/pS2P
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 22-09-15; Last updated: 14-08-25; Version: 11
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RX   PubMed=10497220; DOI=10.1074/jbc.274.40.28549;
RA   Rawson, Robert B.
RA   DeBose-Boyd, Russell A.
RA   Goldstein, Joseph Leonard
RA   Brown, Michael Stuart
RT   "Failure to cleave sterol regulatory element-binding proteins (SREBPs)
RT   causes cholesterol auxotrophy in Chinese hamster ovary cells with
RT   genetic absence of SREBP cleavage-activating protein.";
RL   J. Biol. Chem. 274:28549-28556(1999).
//
RX   PubMed=12482938; DOI=10.1073/pnas.262669399; PMCID=PMC139202;
RA   Yabe, Daisuke
RA   Xia, Zong-Ping
RA   Adams, Christopher M.
RA   Rawson, Robert B.
RT   "Three mutations in sterol-sensing domain of SCAP block interaction
RT   with insig and render SREBP cleavage insensitive to sterols.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16672-16677(2002).
//