Cellosaurus cell line HEp-2 clone 2B (CVCL

Cellosaurus HEp-2 clone 2B (CVCL_2817)

Cross-references
Cell line name	HEp-2 clone 2B
Synonyms	Hep2 (Clone 2B); Hep2 clone B
Accession	CVCL_2817
Resource Identification Initiative	To cite this cell line use: HEp-2 clone 2B (RRID:CVCL_2817)
Comments	Problematic cell line: Contaminated. Parent cell line (HEp-2) has been shown to be a HeLa derivative (PubMed=1246601; PubMed=20143388). Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00310. Population: African American. Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=32994520). Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease	Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1906 (HEp-2)
Sex of cell	Female
Age at sampling	30Y6M
Category	Cancer cell line
Web pages	https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications	PubMed=1246601; DOI=10.1126/science.1246601 Nelson-Rees W.A., Flandermeyer R.R. HeLa cultures defined. Science 191:96-98(1976) PubMed=20143388; DOI=10.1002/ijc.25242 Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I. Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010) PubMed=32994520; DOI=10.1038/s41598-020-73169-y Loiseau V., Cordaux R., Giraud I., Beby-Defaux A., Leveque N., Gilbert C. Characterization of a new case of XMLV (Bxv1) contamination in the human cell line Hep2 (clone 2B). Sci. Rep. 10:16046-16046(2020)
Cell line collections (Providers)	ECACC; 85011412
Cell line databases/resources	CLO; CLO_0003708 CLDB; cl1657
Biological sample resources	BioSample; SAMN03151705
Encyclopedic resources	Wikidata; Q54882754
Entry history
Entry creation	04-Apr-2012
Last entry update	05-Oct-2023
Version number	23