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Cellosaurus HEp-2 clone 2B (CVCL_2817)

[Text version]
Cell line name HEp-2 clone 2B
Synonyms Hep2 (Clone 2B); Hep2 clone B
Accession CVCL_2817
Resource Identification Initiative To cite this cell line use: HEp-2 clone 2B (RRID:CVCL_2817)
Comments Problematic cell line: Contaminated. Parent cell line (HEp-2) has been shown to be a HeLa derivative (PubMed=1246601; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00310.
Population: African American.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=32994520).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1906 (HEp-2)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=1246601; DOI=10.1126/science.1246601
Nelson-Rees W.A., Flandermeyer R.R.
HeLa cultures defined.
Science 191:96-98(1976)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=32994520; DOI=10.1038/s41598-020-73169-y
Loiseau V., Cordaux R., Giraud I., Beby-Defaux A., Leveque N., Gilbert C.
Characterization of a new case of XMLV (Bxv1) contamination in the human cell line Hep2 (clone 2B).
Sci. Rep. 10:16046-16046(2020)

Cell line collections (Providers) ECACC; 85011412
Cell line databases/resources CLO; CLO_0003708
CLDB; cl1657
Biological sample resources BioSample; SAMN03151705
Encyclopedic resources Wikidata; Q54882754
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23