ID   HEp-2 clone 2B
AC   CVCL_2817
SY   Hep2 (Clone 2B); Hep2 clone B
DR   CLO; CLO_0003708
DR   CLDB; cl1657
DR   BioSample; SAMN03151705
DR   ECACC; 85011412
DR   Wikidata; Q54882754
RX   PubMed=1246601;
RX   PubMed=20143388;
RX   PubMed=32994520;
CC   Problematic cell line: Contaminated. Parent cell line (HEp-2) has been shown to be a HeLa derivative (PubMed=1246601; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00310.
CC   Population: African American.
CC   Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=32994520).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1906 ! HEp-2
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 24
RX   PubMed=1246601; DOI=10.1126/science.1246601;
RA   Nelson-Rees W.A., Flandermeyer R.R.;
RT   "HeLa cultures defined.";
RL   Science 191:96-98(1976).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
RX   PubMed=32994520; DOI=10.1038/s41598-020-73169-y;
RA   Loiseau V., Cordaux R., Giraud I., Beby-Defaux A., Leveque N.,
RA   Gilbert C.;
RT   "Characterization of a new case of XMLV (Bxv1) contamination in the
RT   human cell line Hep2 (clone 2B).";
RL   Sci. Rep. 10:16046-16046(2020).