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Cellosaurus MRC-5V2 (CVCL_2627)

[Text version]
Cell line name MRC-5V2
Synonyms MRC-5 V2; MRC5-V2; MRC5V2; MRC-5 SV2; MRC-5-SV2
Accession CVCL_2627
Resource Identification Initiative To cite this cell line use: MRC-5V2 (RRID:CVCL_2627)
Comments Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Proteome analysis by 2D-DE.
Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597.
Cell type: Fibroblast of lung; CL=CL_0002553.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0440 (MRC-5)
Sex of cell Male
Age at sampling 14FW
Category Transformed cell line
STR profile Source(s): ECACC=84100401


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PubMed=6313714; DOI=10.1242/jcs.63.1.77
Huschtscha L.I., Holliday R.
Limited and unlimited growth of SV40-transformed cells from human diploid MRC-5 fibroblasts.
J. Cell Sci. 63:77-99(1983)

PubMed=1965304; DOI=10.1002/elps.1150111203
Celis J.E., Dejgaard K., Madsen P., Leffers H., Gesser B., Honore B., Rasmussen H.H., Olsen E., Lauridsen J.B., Ratz G., Mouritzen S., Basse B., Hellerup M., Celis A., Puype M., Van Damme J., Vandekerckhove J.
The MRC-5 human embryonal lung fibroblast two-dimensional gel cellular protein database: quantitative identification of polypeptides whose relative abundance differs between quiescent, proliferating and SV40 transformed cells.
Electrophoresis 11:1072-1113(1990)

PubMed=21528266; DOI=10.3892/ijo.11.4.717
Kolettas E., Spandidos D.A., Rosenberger R.F.
SV40-transformation of embryonic human diploid fibroblasts results in multiple molecular changes.
Int. J. Oncol. 11:717-725(1997)

Henson J.D.
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006), University of Sydney, Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M., Pickett H.A., Reddel R.R.
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

Cell line collections (Providers) ECACC; 84100401
Cell line databases/resources CLO; CLO_0007868
CLDB; cl3571
Anatomy/cell type resources BTO; BTO:0006540
Chemistry resources ChEMBL-Cells; CHEMBL4513119
Encyclopedic resources Wikidata; Q54906595
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number20