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Cellosaurus MRC-5V2 (CVCL_2627)

[Text version]
Cell line name MRC-5V2
Synonyms MRC-5 V2; MRC5-V2; MRC5V2; MRC-5 SV2; MRC-5-SV2
Accession CVCL_2627
Resource Identification Initiative To cite this cell line use: MRC-5V2 (RRID:CVCL_2627)
Comments Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Proteomics; 2DE.
Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597.
Cell type: Fibroblast of lung; CL=CL_0002553.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0440 (MRC-5)
Sex of cell Male
Age at sampling 14FW
Category Transformed cell line
STR profile Source(s): ECACC=84100401

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811,12
D7S82010
D13S31711,14
D16S53911
TH018
TPOX8
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=6313714; DOI=10.1242/jcs.63.1.77
Lily I. Huschtscha, Robin Holliday;
Limited and unlimited growth of SV40-transformed cells from human diploid MRC-5 fibroblasts.
J. Cell Sci. 63:77-99(1983)

PubMed=1965304; DOI=10.1002/elps.1150111203
Julio Enrique Celis, Kurt Dejgaard, Peder Madsen, Henrik Leffers, Borbala Gesser, Bent Honore, Hanne Holm Rasmussen, Eydfinnur Olsen, Jette B. Lauridsen, Gitte Ratz, Solveig Mouritzen ...Show all 17 authors... , Bodil Basse, Marianne Hellerup, Ariana Celis, Magda Puype, Jozef Van Damme, Joel Vandekerckhove; Show fewer authors
The MRC-5 human embryonal lung fibroblast two-dimensional gel cellular protein database: quantitative identification of polypeptides whose relative abundance differs between quiescent, proliferating and SV40 transformed cells.
Electrophoresis 11:1072-1113(1990)

PubMed=21528266; DOI=10.3892/ijo.11.4.717
Evangelos Kolettas, Demetrios A. Spandidos, Robert F. Rosenberger;
SV40-transformation of embryonic human diploid fibroblasts results in multiple molecular changes.
Int. J. Oncol. 11:717-725(1997)

CLPUB00712
Jeremy David Henson;
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006); University of Sydney; Sydney; Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Jeremy David Henson, Ying Cao, Lily I. Huschtscha, Andy C.-M. Chang, Amy Y.M. Au, Hilda A. Pickett, Roger Robert Reddel;
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

Cross-references
Cell line collections (Providers) ECACC; 84100401
Cell line databases/resources CLO; CLO_0007868
CLDB; cl3571
Anatomy/cell type resources BTO; BTO_0006540
Chemistry resources ChEMBL-Cells; CHEMBL4513119
Encyclopedic resources Wikidata; Q54906595
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22