ID   MRC-5V2
AC   CVCL_2627
SY   MRC-5 V2; MRC5-V2; MRC5V2; MRC-5 SV2; MRC-5-SV2
DR   BTO; BTO:0006540
DR   CLO; CLO_0007868
DR   CLDB; cl3571
DR   ChEMBL-Cells; CHEMBL4513119
DR   ECACC; 84100401
DR   Wikidata; Q54906595
RX   CelloPub=CLPUB00712;
RX   PubMed=1965304;
RX   PubMed=6313714;
RX   PubMed=19935656;
RX   PubMed=21528266;
CC   Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Proteome analysis by 2D-DE.
CC   Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
ST   Source(s): ECACC=84100401
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11,14
ST   D16S539: 11
ST   D5S818: 11,12
ST   D7S820: 10
ST   TH01: 8
ST   TPOX: 8
ST   vWA: 15
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0440 ! MRC-5
SX   Male
AG   14FW
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 20
RX   CelloPub=CLPUB00712;
RA   Henson J.D.;
RT   "The role of alternative lengthening of telomeres in human cancer.";
RL   Thesis PhD (2006), University of Sydney, Australia.
RX   PubMed=1965304; DOI=10.1002/elps.1150111203;
RA   Celis J.E., Dejgaard K., Madsen P., Leffers H., Gesser B., Honore B.,
RA   Rasmussen H.H., Olsen E., Lauridsen J.B., Ratz G., Mouritzen S.,
RA   Basse B., Hellerup M., Celis A., Puype M., Van Damme J.,
RA   Vandekerckhove J.;
RT   "The MRC-5 human embryonal lung fibroblast two-dimensional gel
RT   cellular protein database: quantitative identification of polypeptides
RT   whose relative abundance differs between quiescent, proliferating and
RT   SV40 transformed cells.";
RL   Electrophoresis 11:1072-1113(1990).
RX   PubMed=6313714; DOI=10.1242/jcs.63.1.77;
RA   Huschtscha L.I., Holliday R.;
RT   "Limited and unlimited growth of SV40-transformed cells from human
RT   diploid MRC-5 fibroblasts.";
RL   J. Cell Sci. 63:77-99(1983).
RX   PubMed=19935656; DOI=10.1038/nbt.1587;
RA   Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M.,
RA   Pickett H.A., Reddel R.R.;
RT   "DNA C-circles are specific and quantifiable markers of
RT   alternative-lengthening-of-telomeres activity.";
RL   Nat. Biotechnol. 27:1181-1185(2009).
RX   PubMed=21528266; DOI=10.3892/ijo.11.4.717;
RA   Kolettas E., Spandidos D.A., Rosenberger R.F.;
RT   "SV40-transformation of embryonic human diploid fibroblasts results in
RT   multiple molecular changes.";
RL   Int. J. Oncol. 11:717-725(1997).