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Cellosaurus MM253 (CVCL_2604)

[Text version]
Cell line name MM253
Synonyms MM 253
Accession CVCL_2604
Resource Identification Initiative To cite this cell line use: MM253 (RRID:CVCL_2604)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: CNV analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D849 (MM253-12M)CVCL_UM65 (MM253-3D)CVCL_UM66 (MM253c1)
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): CBA=CBA-1347; DepMap=ACH-001970

Markers:
AmelogeninX
CSF1PO10,11
D2S133816,20
D3S135814
D5S81811,12
D7S8208,10
D8S117911,14
D13S31711,12
D16S53911
D18S5118,19
D19S43315
D21S1129
FGA21
Penta D12
Penta E9,10
TH019.3
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=830403
Goss P.D., Parsons P.G.
The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines.
Cancer Res. 37:152-156(1977)

PubMed=294576; DOI=10.3109/00313027909059039
Muir P.D., Gunz F.W.
A cytogenetic study of eight human melanoma cell lines.
Pathology 11:597-606(1979)

PubMed=460945; DOI=10.3109/00313027909061945
Pope J.H., Morrison L.E., Moss D.J., Parsons P.G., Dunne R.M.
Human malignant melanoma cell lines.
Pathology 11:191-195(1979)

PubMed=7060019
Parsons P.G., Smellie S.G., Morrison L.E., Hayward I.P.
Properties of human melanoma cells resistant to 5-(3',3'-dimethyl-1-triazeno)imidazole-4-carboxamide and other methylating agents.
Cancer Res. 42:1454-1461(1982)

PubMed=6187441
Parsons P.G., Musk P., Goss P.D., Leah J.
Effects of calcium depletion on human cells in vitro and the anomalous behavior of the human melanoma cell line MM170.
Cancer Res. 43:2081-2087(1983)

PubMed=9354451
Castellano M., Pollock P.M., Walters M.K., Sparrow L.E., Down L.M., Gabrielli B.G., Parsons P.G., Hayward N.K.
CDKN2A/p16 is inactivated in most melanoma cell lines.
Cancer Res. 57:4868-4875(1997)

PubMed=10070891; DOI=10.1038/sj.bjc.6690147; PMCID=PMC2362648
Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Br. J. Cancer 79:921-926(1999)

PubMed=15048078; DOI=10.1038/sj.onc.1207563
Pavey S., Johansson P., Packer L., Taylor J., Stark M.S., Pollock P.M., Walker G.J., Boyle G.M., Harper U., Cozzi S.-J., Hansen K., Yudt L., Schmidt C., Hersey P., Ellem K.A.O., O'Rourke M.G.E., Parsons P.G., Meltzer P.S., Ringner M., Hayward N.K.
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Oncogene 23:4060-4067(2004)

PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152
Stark M.S., Hayward N.K.
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Cancer Res. 67:2632-2642(2007)

PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x
Johansson P., Pavey S., Hayward N.K.
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Pigment Cell Res. 20:216-221(2007)

PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676
Dutton-Regester K., Irwin D., Hunt P., Aoude L.G., Tembe V., Pupo G.M., Lanagan C., Carter C.D., O'Connor L., O'Rourke M., Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.
A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.
Mol. Cancer Ther. 11:888-897(2012)

Cross-references
Cell line collections (Providers) CBA; CBA-1347
ECACC; 11072804
Cell line databases/resources cancercelllines; CVCL_2604
DepMap; ACH-001970
Biological sample resources BioSample; SAMN07624425
Encyclopedic resources Wikidata; Q54906084
Gene expression databases GEO; GSM78858
GEO; GSM78859
GEO; GSM78860
GEO; GSM162940
GEO; GSM219451
Polymorphism and mutation databases Cosmic; 889016
Cosmic; 928706
Progenetix; CVCL_2604
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number25