Cellosaurus cell line MM253-12M (CVCL

Cross-references
Cell line name	MM253-12M
Accession	CVCL_D849
Resource Identification Initiative	To cite this cell line use: MM253-12M (RRID:CVCL_D849)
Comments	Selected for resistance to: ChEBI; CHEBI_28876; Melphalan (L-phenylalanine mustard; LPAM; Alkeran). Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (from parent cell line).
Disease	Amelanotic melanoma (NCIt: C3802)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_2604 (MM253)
Sex of cell	Male
Age at sampling	46Y
Category	Cancer cell line
Publications	PubMed=669848; DOI=10.1002/ijc.2910210407 Peter G. Parsons, Leanne E. Morrison; Melphalan-induced chromosome damage in sensitive and resistant human melanoma cell lines. Int. J. Cancer 21:438-443(1978) PubMed=6163526 Peter G. Parsons, F.B. Carter, Leanne E. Morrison, Regis Mary Dunne; Mechanism of melphalan resistance developed in vitro in human melanoma cells. Cancer Res. 41:1525-1534(1981) PubMed=7060019 Peter G. Parsons, Susan G. Smellie, Leanne E. Morrison, Ian P. Hayward; Properties of human melanoma cells resistant to 5-(3',3'-dimethyl-1-triazeno)imidazole-4-carboxamide and other methylating agents. Cancer Res. 42:1454-1461(1982)
Cell line databases/resources	cancercelllines; CVCL_D849
Encyclopedic resources	Wikidata; Q54906085
Entry history
Entry creation	22-Oct-2012
Last entry update	19-Dec-2024
Version number	17