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Cellosaurus HuNS1 (CVCL_2526)

[Text version]
Cell line name HuNS1
Synonyms HUNS1
Accession CVCL_2526
Resource Identification Initiative To cite this cell line use: HuNS1 (RRID:CVCL_2526)
Comments Group: Patented cell line.
Problematic cell line: Misclassified. Grand-parent cell line (GM01500) was originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8644.
Population: Caucasian.
Characteristics: Secretes IgG2 kappa.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American1.22
East Asian, North0
East Asian, South1.71
South Asian5.64
European, North56.19
European, South35.24
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_H615 (GM1500-6TG-A11)
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): ATCC=CRL-8644

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133820,21,22
D3S135815,17
D5S81810,12
D7S82010
D8S117911,14
D13S31712
D16S53911
D18S5114,18
D19S43315,15.2
D21S1130,33.2
FGA24
Penta D9,12
Penta E16,17
TH019,9.3
TPOX8
vWA16,19

Run an STR similarity search on this cell line
Publications

Patent=US4720459
Winkelhake J.L.
Myelomas for producing human/human hybridomas.
Patent number US4720459, 19-Jan-1988

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-8644
Cell line databases/resources CLO; CLO_0004298
cancercelllines; CVCL_2526
Cell_Model_Passport; SIDM01556
DepMap; ACH-000829
IGRhCellID; HuNS1
Biological sample resources BioSample; SAMN03471205
BioSample; SAMN10987603
Chemistry resources PharmacoDB; HuNS1_641_2019
Encyclopedic resources Wikidata; Q54896885
Experimental variables resources EFO; EFO_0002207
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
GEO; GSM887150
GEO; GSM888222
Polymorphism and mutation databases Cosmic; 683664
IARC_TP53; 21388
LiGeA; CCLE_868
Progenetix; CVCL_2526
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number26