ID   HuNS1
AC   CVCL_2526
SY   HUNS1
DR   CLO; CLO_0004298
DR   EFO; EFO_0002207
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; CRL-8644
DR   BioSample; SAMN03471205
DR   BioSample; SAMN10987603
DR   cancercelllines; CVCL_2526
DR   Cell_Model_Passport; SIDM01556
DR   Cosmic; 683664
DR   DepMap; ACH-000829
DR   GEO; GSM887150
DR   GEO; GSM888222
DR   IARC_TP53; 21388
DR   IGRhCellID; HuNS1
DR   LiGeA; CCLE_868
DR   PharmacoDB; HuNS1_641_2019
DR   Progenetix; CVCL_2526
DR   Wikidata; Q54896885
RX   Patent=US4720459;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=30285677;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Group: Patented cell line.
CC   Problematic cell line: Misclassified. Grand-parent cell line (GM01500) was originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8644.
CC   Population: Caucasian.
CC   Characteristics: Secretes IgG2 kappa.
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=1.22%; East Asian, North=0%; East Asian, South=1.71%; South Asian=5.64%; European, North=56.19%; European, South=35.24% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): ATCC=CRL-8644
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 12
ST   D16S539: 11
ST   D18S51: 14,18
ST   D19S433: 15,15.2
ST   D21S11: 30,33.2
ST   D2S1338: 20,21,22
ST   D3S1358: 15,17
ST   D5S818: 10,12
ST   D7S820: 10
ST   D8S1179: 11,14
ST   FGA: 24
ST   Penta D: 9,12
ST   Penta E: 16,17
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 16,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_H615 ! GM1500-6TG-A11
SX   Male
AG   Age unspecified
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 28
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   Patent=US4720459;
RA   Winkelhake, Jeffrey Lee
RT   "Myelomas for producing human/human hybridomas.";
RL   Patent number US4720459, 19-Jan-1988.
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786;
RA   Tan, Kar-Tong
RA   Ding, Ling-Wen
RA   Sun, Qiao-Yang
RA   Lao, Zhen-Tang
RA   Chien, Wenwen
RA   Ren, Xi
RA   Xiao, Jin-Fen
RA   Loh, Xin-Yi
RA   Xu, Liang
RA   Lill, Michael
RA   Mayakonda, Anand
RA   Lin, De-Chen
RA   Yang, Henry He
RA   Koeffler, Harold Phillip
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//