| Cell line name |
HCA7 colony 29 |
|---|
| Synonyms |
HCA-7 Colony 29; HCA-7 Colony29; Col 29 |
|---|
| Accession |
CVCL_2474 |
|---|
| Resource Identification Initiative |
To cite this cell line use: HCA7 colony 29 (RRID:CVCL_2474) |
|---|
| Comments |
Characteristics: Useful for studying the role of PTGS2 (Cox-2) in cancer cell biology and the investigation of colorectal epithelial cell polarity.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu582fs*20 (c.1742_1743insA); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg479Ter (c.1435C>T); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro301Glnfs*44 (c.898delC); Zygosity=Unspecified (from parent cell line).
|
|---|
| Disease |
Colon adenocarcinoma (NCIt: C4349) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0289 (HCA7) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
58Y |
|---|
| Category |
Cancer cell line |
|---|
| STR profile |
Source(s): ECACC=02091238
Markers:
Run an STR similarity search on this cell line |
|---|
| Publications | PubMed=8410493; DOI=10.1002/path.1711700407
Katrina A. Marsh, Gordon W.H. Stamp, Susan C. Kirkland;
Isolation and characterization of multiple cell types from a single human colonic carcinoma: tumourigenicity of these cell types in a xenograft system.
J. Pathol. 170:441-450(1993) PubMed=9012840; DOI=10.1073/pnas.94.2.657; PMCID=PMC19569
Robert J. Coffey, Chris J. Hawkey, Lars Damstrup, Ramona Graves-Deal, Vincent C. Daniel, Peter James Dempsey, Rebecca Chinery, Susan C. Kirkland, Raymond N. DuBois, Thomas L. Jetton, Jason Drew Morrow;
Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 94:657-662(1997) |
|---|
| Cross-references |
|---|
| Cell line collections (Providers) |
ECACC; 02091238
Ximbio; 152459 - Discontinued
|
|---|
| Encyclopedic resources |
Wikidata; Q54881498
|
|---|
| Entry history |
|---|
| Entry creation | 04-Apr-2012 |
|---|
| Last entry update | 19-Dec-2024 |
|---|
| Version number | 16 |
|---|
