ID   HCA7 colony 29
AC   CVCL_2474
SY   HCA-7 Colony 29; HCA-7 Colony29; Col 29
DR   ECACC; 02091238
DR   Wikidata; Q54881498
DR   Ximbio; 152459
RX   PubMed=8410493;
RX   PubMed=9012840;
CC   Characteristics: Useful for studying the role of PTGS2 (Cox-2) in cancer cell biology and the investigation of colorectal epithelial cell polarity.
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Glu582fs*20 (c.1742_1743insA); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg479Ter (c.1435C>T); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro301Glnfs*44 (c.898delC); Zygosity=Unspecified (from parent cell line).
CC   Discontinued: Ximbio; 152459; probable.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): ECACC=02091238
ST   Amelogenin: X
ST   CSF1PO: 11,14
ST   D13S317: 9
ST   D16S539: 10,11
ST   D5S818: 8,12
ST   D7S820: 11,12
ST   TH01: 6,7
ST   TPOX: 8,10
ST   vWA: 14,16
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0289 ! HCA7
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 16
//
RX   PubMed=8410493; DOI=10.1002/path.1711700407;
RA   Marsh K.A., Stamp G.W.H., Kirkland S.C.;
RT   "Isolation and characterization of multiple cell types from a single
RT   human colonic carcinoma: tumourigenicity of these cell types in a
RT   xenograft system.";
RL   J. Pathol. 170:441-450(1993).
//
RX   PubMed=9012840; DOI=10.1073/pnas.94.2.657; PMCID=PMC19569;
RA   Coffey R.J., Hawkey C.J., Damstrup L., Graves-Deal R., Daniel V.C.,
RA   Dempsey P.J., Chinery R., Kirkland S.C., DuBois R.N., Jetton T.L.,
RA   Morrow J.D.;
RT   "Epidermal growth factor receptor activation induces nuclear targeting
RT   of cyclooxygenase-2, basolateral release of prostaglandins, and
RT   mitogenesis in polarizing colon cancer cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:657-662(1997).
//