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Cellosaurus 1BR3 (CVCL_2279)

[Text version]
Cell line name 1BR3
Synonyms 1BR.3; 1.BR3; 1BR; 1Br; 1 BRighton
Accession CVCL_2279
Resource Identification Initiative To cite this cell line use: 1BR3 (RRID:CVCL_2279)
Comments Doubling time: 24 hours (PubMed=8609460).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2280 (1BR.3.G)CVCL_2282 (1BR.3.N)CVCL_E3V7 (1BR3-hTERT)
Sex of cell Male
Age at sampling 23Y
Category Finite cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX,Y
D8S117912,14
D18S5112,14
D21S1130
FGA21,22
TH016,9.3
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=1196376; DOI=10.1038/258427a0
Alexander Malcolm R. Taylor, David G. Harnden, Colin Francis Arlett, Susan A. Harcourt, Alan R. Lehmann, Sean Stevens, Bryn A. Bridges;
Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity.
Nature 258:427-429(1975)

PubMed=1214825; DOI=10.1016/0027-5107(75)90209-2
Colin Francis Arlett, Susan A. Harcourt, Bernard C. Broughton;
The influence of caffeine on cell survival in excision-proficient and excision-deficient xeroderma pigmentosum and normal human cell strains following ultraviolet-light irradiation.
Mutat. Res. 33:341-346(1975)

PubMed=837385
Alan R. Lehmann, Susan Kirk-Bell, Colin Francis Arlett, Susan A. Harcourt, Elizabeth A. de Weerd-Kastelein, Wilma Keijzer, Patrick Hall-Smith;
Repair of ultraviolet light damage in a variety of human fibroblast cell strains.
Cancer Res. 37:904-910(1977)

PubMed=7360141; DOI=10.1016/0027-5107(80)90180-3
Richard R. Marshall, Colin Francis Arlett, Susan A. Harcourt, Bernard C. Broughton;
Increased sensitivity of cell strains from Cockayne's syndrome to sister-chromatid-exchange induction and cell killing by UV light.
Mutat. Res. 69:107-112(1980)

PubMed=7471106
Colin Francis Arlett, Susan A. Harcourt;
Survey of radiosensitivity in a variety of human cell strains.
Cancer Res. 40:926-932(1980)

PubMed=11219864; DOI=10.1093/carcin/1.9.745
Colin Francis Arlett, Susan A. Harcourt, Alan R. Lehmann, Sean Stevens, Malcolm Andrew Ferguson-Smith, W. Neil Morley;
Studies on a new case of xeroderma pigmentosum (XP3BR) from complementation group G with cellular sensitivity to ionizing radiation.
Carcinogenesis 1:745-751(1980)

PubMed=7067035; DOI=10.1093/carcin/3.1.33
Ian A. Teo, Colin Francis Arlett;
The response of a variety of human fibroblast cell strains to the lethal effects of alkylating agents.
Carcinogenesis 3:33-37(1982)

DOI=10.1007/978-1-4757-1117-2_12
Colin Francis Arlett, Susan A. Harcourt;
The mutagen sensitivity response of cells from individuals heterozygous for DNA repair deficiency genes.
(In book chapter) The use of human cells for the evaluation of risk from physical and chemical agents; Castellani, Amleto (eds.); pp.155-167; Springer; Boston; USA (1983)

PubMed=6408472; DOI=10.1016/0027-5107(83)90177-X
Ian A. Teo, Colin Francis Arlett, Susan A. Harcourt, Anne Priestley, Bernard C. Broughton;
Multiple hypersensitivity to mutagens in a cell strain (46BR) derived from a patient with immuno-deficiencies.
Mutat. Res. 107:371-386(1983)

PubMed=6600729; DOI=10.1080/09553008314550171
Colin Francis Arlett, Anne Priestley;
Defective recovery from potentially lethal damage in some human fibroblast cell strains.
Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 43:157-167(1983)

PubMed=2903889; DOI=10.1080/09553008814552321
Colin Francis Arlett, Michael H.L. Green, Anne Priestley, Susan A. Harcourt, Lynne V. Mayne;
Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
Int. J. Radiat. Biol. 54:911-928(1988)

PubMed=2973075; DOI=10.2307/3577479
Bernard Fertil, Patrick J. Deschavanne, Danielle Debieu, Edmond-Philippe Malaise;
Correlation between PLD repair capacity and the survival curve of human fibroblasts in exponential growth phase: analysis in terms of several parameters.
Radiat. Res. 116:74-88(1988)

PubMed=2400879; DOI=10.1259/0007-1285-63-752-624
Piers N. Plowman, Bryn A. Bridges, Colin Francis Arlett, Anke Hinney, Judith Eve Kingston;
An instance of clinical radiation morbidity and cellular radiosensitivity, not associated with ataxia-telangiectasia.
Br. J. Radiol. 63:624-628(1990)

PubMed=1372096; DOI=10.1016/0921-8777(92)90074-d
Colin Francis Arlett, Susan A. Harcourt, Jane Cole, Michael H.L. Green, Alexander Vincent Anstey;
A comparison of the response of unstimulated and stimulated T-lymphocytes and fibroblasts from normal, xeroderma pigmentosum and trichothiodystrophy donors to the lethal action of UV-C.
Mutat. Res. 273:127-135(1992)

PubMed=7882314
Christophe Badie, George Iliakis, Nicolas Foray, Ghazi A. Alsbeih, Gabriel E. Pantellias, Ryuichi Okayasu, Nge Cheong, Nicola S. Russell, Adrian C. Begg, Colin Francis Arlett, Edmond-Philippe Malaise;
Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from a radiosensitive leukemia patient.
Cancer Res. 55:1232-1234(1995)

PubMed=8609460; DOI=10.1080/095530096146075
Ghazi A. Alsbeih, Bernard Fertil, Colin Francis Arlett, Edmond-Philippe Malaise;
High split-dose recovery in hypersensitive human fibroblasts: a case of induced radioresistance?
Int. J. Radiat. Biol. 69:225-239(1996)

PubMed=8823375; DOI=10.1111/1523-1747.ep12584287
Shin-ichi Moriwaki, Miria Stefanini, Alan R. Lehmann, Jan Hendrik Jozef Hoeijmakers, Jay H. Robbins, Isabelle Rapin, Elena Botta, Bianca Tanganelli, Wim Vermeulen, Bernard C. Broughton, Kenneth H. Kraemer;
DNA repair and ultraviolet mutagenesis in cells from a new patient with xeroderma pigmentosum group G and Cockayne syndrome resemble xeroderma pigmentosum cells.
J. Invest. Dermatol. 107:647-653(1996)

PubMed=10022907; DOI=10.1128/mcb.19.3.2206; PMCID=PMC84013
Agnes M. Cordonnier, Alan R. Lehmann, Robert P.P. Fuchs;
Impaired translesion synthesis in xeroderma pigmentosum variant extracts.
Mol. Cell. Biol. 19:2206-2211(1999)

PubMed=10987302
Pierre-Marie Girard, Nicolas Foray, Markus Stumm, Alastair P.W. Waugh, Enriqueta Riballo, Richard S. Maser, William P. Phillips, John H.J. Petrini, Colin Francis Arlett, Penelope Ann Jeggo;
Radiosensitivity in Nijmegen breakage syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects.
Cancer Res. 60:4881-4888(2000)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=12082606; DOI=10.1038/sj.onc.1205596
Pierre-Marie Girard, Enriqueta Riballo, Adrian C. Begg, Alastair P.W. Waugh, Penelope Ann Jeggo;
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest.
Oncogene 21:4191-4199(2002)

PubMed=12604777; DOI=10.1073/pnas.0437964100; PMCID=PMC151363
Yan Dai, Boris Kysela, Les A. Hanakahi, Kostas Manolis, Enriqueta Riballo, Markus Stumm, Terry Odell Harville, Stephen Craig West, Marjorie Ann Oettinger, Penelope Ann Jeggo;
Nonhomologous end joining and V(D)J recombination require an additional factor.
Proc. Natl. Acad. Sci. U.S.A. 100:2462-2467(2003)

PubMed=15130666; DOI=10.1016/j.exger.2004.02.002
Joanna M. Bridger, Ian R. Kill;
Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis.
Exp. Gerontol. 39:717-724(2004)

PubMed=15574327; DOI=10.1016/j.molcel.2004.10.029
Enriqueta Riballo, Martin Kuhne, Nicole Rief, Aidan J. Doherty, Graeme C.M. Smith, Maria-Jose Recio, Caroline Reis, Kirsten Dahm, Andreas Fricke, Andrea Krempler, Antony R. Parker ...Show all 15 authors... , Stephen Philip Jackson, Andrew R. Gennery, Penelope Ann Jeggo, Markus Lobrich; Show fewer authors
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Mol. Cell 16:715-724(2004)

PubMed=16714754; DOI=10.1259/bjr/83726649
Colin Francis Arlett, Piers N. Plowman, Paul Bryan Rogers, Christopher N. Parris, Fatemeh Abbaszadeh, Michael H.L. Green, Trevor J. McMillan, Cyd Bush, Nicolas Foray, Alan R. Lehmann;
Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum.
Br. J. Radiol. 79:510-517(2006)

PubMed=19179371; DOI=10.1093/nar/gkp023; PMCID=PMC2651789
Siripan Limsirichaikul, Atsuko Niimi, Heather Fawcett, Alan R. Lehmann, Shunichi Yamashita, Tomoo Ogi;
A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of ethynyl deoxyuridine (EdU).
Nucleic Acids Res. 37:e31.1-e31.10(2009)

Cross-references
Cell line collections (Providers) ECACC; 90011801
Cell line databases/resources CLO; CLO_0001157
CLDB; cl31
Encyclopedic resources Wikidata; Q54582783
Experimental variables resources EFO; EFO_0022560
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number21