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Cellosaurus TFK-1 (CVCL_2214)

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Cell line name TFK-1
Synonyms TFK1
Accession CVCL_2214
Resource Identification Initiative To cite this cell line use: TFK-1 (RRID:CVCL_2214)
Comments Part of: Biliary tract cancer cell line atlas.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: ~37 hours (Note=At 40th passage) (PubMed=8693487); ~40 hours (DSMZ=ACC-344).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Misspelling: TFKK-1; PubMed=22490663; Note=In supplementary figure 2.
Derived from site: In situ; Extrahepatic bile duct; UBERON=UBERON_0003703.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Trp91Ter (c.272G>A); ClinVar=VCV000233650; Zygosity=Homozygous (DepMap=ACH-001673).
Disease Cholangiocarcinoma (NCIt: C4436)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_QZ53 (RTFK-1)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001673; DSMZ=ACC-344; RCB=RCB2537; TKG=TKG 0367

Markers:
AmelogeninX,Y
CSF1PO10
D2S133818,22
D3S135817,18
D5S8189,12
D7S82010 (DSMZ=ACC-344)
10,11 (DepMap=ACH-001673; RCB=RCB2537; TKG=TKG 0367)
D8S117913,14
D13S31714
D16S5399
D18S5116
D19S43314,15
D21S1130
FGA20,23
Penta D13,14
Penta E5,18 (DepMap=ACH-001673)
18 (DSMZ=ACC-344)
TH016
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=8693487; DOI=10.1620/tjem.177.61
Susumu Saijyo, Toshio Kudo, Masanori Suzuki, Yu Katayose, Masao Shinoda, Taisei Muto, Kenji Fukuhara, Takao Suzuki, Seiki Matsuno;
Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1.
Tohoku J. Exp. Med. 177:61-71(1995)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Yuriko Saiki, Yuki Yoshino, Hiroko Fujimura, Tatsuya Manabe, Yuki Kudo, Miki Shimada, Nariyasu Mano, Tomohiro Nakano, Yoonha Lee, Shinjiro Shimizu, Shinya Oba ...Show all 23 authors... , Sho Fujiwara, Hideyuki Shimizu, Na Chen, Zhaleh Kashkouli Nezhad, Guo Jin, Shinichi Fukushige, Makoto Sunamura, Masaharu Ishida, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Akira Horii; Show fewer authors
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

CLPUB00275
Sebastian Zach, Emrullah Birgin, Felix Ruckert;
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442; PMCID=PMC5458737
Supriya Kumar Saha, John D. Gordan, Benjamin P. Kleinstiver, Phuong Vu, Mortada S. Najem, Jia-Chi Yeo, Lei Shi, Yasutaka Kato, Rebecca S. Levin, James T. Webber, Leah J. Damon ...Show all 28 authors... , Regina K. Egan, Patricia Greninger, Ultan McDermott, Mathew J. Garnett, Roger L. Jenkins, Kimberly M. Rieger-Christ, Travis B. Sullivan, Aram Francis Hezel, Andrew S. Liss, Yusuke Mizukami, Lipika Goyal, Cristina Rosa Ferrone, Andrew Xiu-Xuan Zhu, Jae Keith Joung, Kevan Michael Shokat, Cyril Henri Benes, Nabeel M. Bardeesy; Show fewer authors
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=31077409; DOI=10.1002/hep.30704
Gunya Sittithumcharee, Orawan Suppramote, Kulthida Vaeteewoottacharn, Chumphon Sirisuksakun, Supawan Jamnongsong, Phatthamon Laphanuwat, Monthira Suntiparpluacha, Arriya Matha, Porncheera Chusorn, Pongsakorn Buraphat, Chumpot Kakanaporn ...Show all 21 authors... , Komgrid Charngkaew, Atit Silsirivanit, Krittiya Korphaisarn, Somchai Limsrichamrern, Pinpat Tripatara, Chawalit Pairojkul, Sopit Wongkham, Somponnat Sampattavanich, Seiji Okada, Siwanon Jirawatnotai; Show fewer authors
Dependency of cholangiocarcinoma on cyclin D-dependent kinase activity.
Hepatology 70:1614-1630(2019)

PubMed=32899426; DOI=10.3390/cancers12092510; PMCID=PMC7565451
Dominique Scherer, Marcela Davila-Lopez, Benjamin Goeppert, Sanna Abrahamsson, Rosa Gonzalez Silos, Igor Nova, Katherine Marcelain, Juan Carlos Roa, David Ibberson, Sinan U. Umu, Trine Ballestad Rounge ...Show all 13 authors... , Stephanie Roessler, Justo Lorenzo-Bermejo; Show fewer authors
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Cancers (Basel) 12:2510.1-2510.14(2020)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Abdulkadir Isidan, Ali Yenigun, Daiki Soma, Eric Aksu, Kevin Lopez, Yujin Park, Arthur Cross-Najafi, Ping Li, Debjyoti Kundu, Michael G. House, Sanjukta Chakraborty ...Show all 17 authors... , Shannon Glaser, Lindsey Kennedy, Heather Francis, Wen-Jun Zhang, Gianfranco D. Alpini, Burcin Ekser; Show fewer authors
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448
Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, Prabhat Kattel, Lauren Kenney, Joshua Merritt, Ramzi Adil, Qi-Biao Wu, Yuan-Li Zhen ...Show all 39 authors... , Robert Morris, Johannes Kreuzer, Meena Kathiresan, Xcanda Ixchel Herrera Lopez, Haley Ellis, Ilaria G. Gritti, Lilian Lecorgne, Ines Farag, Alexandra Popa, William Shen, Hiroyuki Kato, Qin Xu, Eranga Roshan Balasooriya, Meng-Ju Wu, Saireudee Chaturantabut, Robin Kate Kelley, James Mark Cleary, Michael Scott Lawrence, David E. Root, Cyril Henri Benes, Vikram Deshpande, Dejan Juric, William Raj Sellers, Cristina Rosa Ferrone, Wilhelm Haas, Francisca Vazquez, Gad Getz, Nabeel M. Bardeesy; Show fewer authors
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
bioRxiv 2024:07.04.601970-07.04.601970(2024)

Cross-references
Cell line collections (Providers) DSMZ; ACC-344
RCB; RCB2537
TKG; TKG 0367
Cell line databases/resources CLO; CLO_0009330
CLO; CLO_0050010
cancercelllines; CVCL_2214
Cell_Model_Passport; SIDM01462
DepMap; ACH-001673
DSMZCellDive; ACC-344
Biological sample resources BioSample; SAMN03471922
BioSample; SAMN03473356
Encyclopedic resources Wikidata; Q54972205
Gene expression databases FANTOM5_SSTAR; 10496-107C1
Polymorphism and mutation databases Cosmic; 927187
Cosmic; 1122354
Cosmic; 1373550
Cosmic; 2674051
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30