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Cellosaurus M-07e (CVCL_2106)

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Cell line name M-07e
Synonyms M-07E; M-O7e; M07-e; M07e; Mo7e; MO7e; M07E; MO7E
Accession CVCL_2106
Resource Identification Initiative To cite this cell line use: M-07e (RRID:CVCL_2106)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: 46 +- 12 hours (PubMed=9096695); ~40 hours (DSMZ=ACC-104).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
HLA typing Source: DSMZCellDive=ACC-104
Class I
HLA-AA*24:02:01,66:01:01
HLA-BB*13:02:01,49:01:01
HLA-CC*06:02:01;07:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African8.96
Native American0
East Asian, North0.92
East Asian, South0
South Asian3.01
European, North45.47
European, South41.63
Disease Childhood acute megakaryoblastic leukemia (NCIt: C7972)
Acute megakaryoblastic leukemia (ORDO: Orphanet_518)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D630 (M-07)
Children:
CVCL_RM07 (M-07e/TPO)
Sex of cell Female
Age at sampling 6M
Category Cancer cell line
STR profile Source(s): CCRID=1101HUM-PUMC000112; DSMZ=ACC-104

Markers:
AmelogeninX
CSF1PO9,10
D2S133819,25
D3S135816,19
D5S81811
D7S82011
D8S117913 (DSMZ=ACC-104)
13,16 (CCRID=1101HUM-PUMC000112)
D13S31710,11
D16S53911
D18S5115,20
D19S43314,15
D21S1130,32.2
FGA18,22
Penta D9
Penta E12,14
TH016,8
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=MO7E
Publications

PubMed=2273055; DOI=10.1002/jcp.1041450310
Gian Carlo Avanzi, Maria Felice Brizzi, JoAnn S. Witek-Giannotti, Agnes Brennan, Yu-Chung Yang, Luigi Pegoraro, Steven C. Clark;
M-07e human leukemic factor-dependent cell line provides a rapid and sensitive bioassay for the human cytokines GM-CSF and IL-3.
J. Cell. Physiol. 145:458-464(1990)

PubMed=9096695; DOI=10.1038/sj.leu.2400621
Hans Gunther Drexler, Margarete Zaborski, Hilmar Quentmeier;
Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.
Leukemia 11:541-551(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11414198; DOI=10.1007/s004320000207
Harald Lahm, Sabine Andre, Andreas Hoeflich, Jurgen R. Fischer, Bernard Sordat, Herbert Kaltner, Eckhard Wolf, Hans-Joachim Gabius;
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=28109323; DOI=10.1186/s13045-017-0396-0; PMCID=PMC5251306
Riccardo Masetti, Salvatore Nicola Bertuccio, Annalisa Astolfi, Francesca Chiarini, Annalisa Lonetti, Valentina Indio, Matilde De Luca, Jessica Bandini, Salvatore Serravalle, Monica Franzoni, Martina Pigazzi ...Show all 15 authors... , Alberto Maria Martelli, Giuseppe Basso, Franco Locatelli, Andrea Pession; Show fewer authors
Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene.
J. Hematol. Oncol. 10:26.1-26.5(2017)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023)

Cross-references
Cell line collections (Providers) CLS; 305105
DSMZ; ACC-104
ICLC; HTL04002
NCBI_Iran; C621
Cell line databases/resources CLO; CLO_0007447
CLDB; cl3281
CLDB; cl7156
cancercelllines; CVCL_2106
CCRID; 1101HUM-PUMC000112
Cell_Model_Passport; SIDM01640
DepMap; ACH-000602
DSMZCellDive; ACC-104
Lonza; 485
Anatomy/cell type resources BTO; BTO_0005248
Biological sample resources BioSample; SAMN03473408
BioSample; SAMN10988568
Chemistry resources PharmacoDB; M07e_875_2019
Encyclopedic resources Wikidata; Q54903379
Experimental variables resources EFO; EFO_0022426
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM236792
GEO; GSM236828
GEO; GSM743416
GEO; GSM887287
GEO; GSM888362
GEO; GSM1446743
Polymorphism and mutation databases Cosmic; 787447
Cosmic; 975265
Cosmic; 999723
Cosmic; 1012082
Cosmic; 1181607
Cosmic; 1281323
Cosmic; 1524835
Cosmic; 1633511
Cosmic; 2306215
IARC_TP53; 30115
LiGeA; CCLE_603
Progenetix; CVCL_2106
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number41