ID   M-07e
AC   CVCL_2106
SY   M-07E; M-O7e; M07-e; M07e; Mo7e; MO7e; M07E; MO7E
DR   BTO; BTO:0005248
DR   CLO; CLO_0007447
DR   EFO; EFO_0022426
DR   CLDB; cl3281
DR   CLDB; cl7156
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   BioSample; SAMN03473408
DR   BioSample; SAMN10988568
DR   cancercelllines; CVCL_2106
DR   CCRID; 1101HUM-PUMC000112
DR   Cell_Model_Passport; SIDM01640
DR   CLS; 305105
DR   Cosmic; 787447
DR   Cosmic; 975265
DR   Cosmic; 999723
DR   Cosmic; 1012082
DR   Cosmic; 1181607
DR   Cosmic; 1281323
DR   Cosmic; 1524835
DR   Cosmic; 1633511
DR   Cosmic; 2306215
DR   DepMap; ACH-000602
DR   DSMZ; ACC-104
DR   DSMZCellDive; ACC-104
DR   GEO; GSM236792
DR   GEO; GSM236828
DR   GEO; GSM743416
DR   GEO; GSM887287
DR   GEO; GSM888362
DR   GEO; GSM1446743
DR   IARC_TP53; 30115
DR   ICLC; HTL04002
DR   LiGeA; CCLE_603
DR   Lonza; 485
DR   NCBI_Iran; C621
DR   PharmacoDB; M07e_875_2019
DR   Progenetix; CVCL_2106
DR   Wikidata; Q54903379
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2273055;
RX   PubMed=9096695;
RX   PubMed=11414198;
RX   PubMed=16408098;
RX   PubMed=22460905;
RX   PubMed=28109323;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31160637;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=MO7E
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: LL-100 blood cancer cell line panel.
CC   Population: Caucasian.
CC   Doubling time: 46 +- 12 hours (PubMed=9096695); ~40 hours (DSMZ=ACC-104).
CC   HLA typing: A*24:02:01,66:01:01; B*13:02:01,49:01:01; C*06:02:01;07:01:01 (DSMZCellDive=ACC-104).
CC   Sequence variation: Gene fusion; HGNC; 31677; ANO7 + HGNC; 17887; DHDH; Name(s)=ANO7-DHDH (PubMed=31160637).
CC   Sequence variation: Gene fusion; HGNC; 1537; CBFA2T3 + HGNC; 29450; GLIS2; Name(s)=CBFA2T3-GLIS2, ETO2-GLIS2 (PubMed=28109323).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (DepMap=ACH-000602).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=8.96%; Native American=0%; East Asian, North=0.92%; East Asian, South=0%; South Asian=3.01%; European, North=45.47%; European, South=41.63% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): CCRID=1101HUM-PUMC000112; DSMZ=ACC-104
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 10,11
ST   D16S539: 11
ST   D18S51: 15,20
ST   D19S433: 14,15
ST   D21S11: 30,32.2
ST   D2S1338: 19,25
ST   D3S1358: 16,19
ST   D5S818: 11
ST   D7S820: 11
ST   D8S1179: 13 (DSMZ=ACC-104)
ST   D8S1179: 13,16 (CCRID=1101HUM-PUMC000112)
ST   FGA: 18,22
ST   Penta D: 9
ST   Penta E: 12,14
ST   TH01: 6,8
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C7972; Childhood acute megakaryoblastic leukemia
DI   ORDO; Orphanet_518; Acute megakaryoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_D630 ! M-07
SX   Female
AG   6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 38
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=2273055; DOI=10.1002/jcp.1041450310;
RA   Avanzi G.C., Brizzi M.F., Giannotti J., Brennan A., Yang Y.-C.,
RA   Pegoraro L., Clark S.C.;
RT   "M-07e human leukemic factor-dependent cell line provides a rapid and
RT   sensitive bioassay for the human cytokines GM-CSF and IL-3.";
RL   J. Cell. Physiol. 145:458-464(1990).
//
RX   PubMed=9096695; DOI=10.1038/sj.leu.2400621;
RA   Drexler H.G., Zaborski M., Quentmeier H.;
RT   "Thrombopoietin supports the continuous growth of cytokine-dependent
RT   human leukemia cell lines.";
RL   Leukemia 11:541-551(1997).
//
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H.,
RA   Wolf E., Gabius H.-J.;
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
//
RX   PubMed=16408098; DOI=10.1038/sj.leu.2404081;
RA   Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.;
RT   "JAK2 V617F tyrosine kinase mutation in cell lines derived from
RT   myeloproliferative disorders.";
RL   Leukemia 20:471-476(2006).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=28109323; DOI=10.1186/s13045-017-0396-0; PMCID=PMC5251306;
RA   Masetti R., Bertuccio S.N., Astolfi A., Chiarini F., Lonetti A.,
RA   Indio V., De Luca M., Bandini J., Serravalle S., Franzoni M.,
RA   Pigazzi M., Martelli A.M., Basso G., Locatelli F., Pession A.;
RT   "Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion
RT   gene.";
RL   J. Hematol. Oncol. 10:26.1-26.5(2017).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C.,
RA   Yang H.H., Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144;
RA   Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.;
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:E0210404-E0210404(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646;
RA   Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M.,
RA   MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.;
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218-8218(2019).
//