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Cellosaurus EM-3 (CVCL_2033)

[Text version]
Cell line name EM-3
Synonyms EM3
Accession CVCL_2033
Resource Identification Initiative To cite this cell line use: EM-3 (RRID:CVCL_2033)
Comments Population: Caucasian.
Doubling time: 2 days (CelloPub=CLPUB00038); ~40 hours (DSMZ=ACC-134).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Childhood chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C7320)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1196 ! EM-2
Sex of cell Female
Age at sampling 5Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-134; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D2S133822,24
D3S135814,16
D5S8188,12
D7S82010
D8S117914
D13S3179,12
D16S53911,12
D18S5113
D19S43315,16
D21S1130
FGA21,22
Penta D13,14
Penta E7,16
TH019.3
TPOX8,12
vWA14,17

Run an STR similarity search on this cell line
Publications

CLPUB00038
Armand Keating, Paul Joseph Martin, Irwin David Bernstein, Thalia Papayannopoulou, Wendy Herlihy Raskind, Jack W. Singer;
EM-2 and EM-3: two new Ph1+ myeloid cell lines.
(In book chapter) Normal and neoplastic hematopoiesis, UCLA symposia on molecular and cellular biology, New Series Vol. 9; Golde, David W. & Marks, Paul Alan (eds.); pp.513-520; Alan R. Liss; New York; USA (1983)

PubMed=3856862; DOI=10.1073/pnas.82.6.1810; PMCID=PMC397362
James B. Konopka, Susan M. Watanabe, Jack W. Singer, Steven J. Collins, Owen Neil Witte;
Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.
Proc. Natl. Acad. Sci. U.S.A. 82:1810-1814(1985)

PubMed=3030532; DOI=10.1016/0165-4608(87)90188-9
Wendy Herlihy Raskind, Christine M. Disteche, Armand Keating, Jack W. Singer;
Correlation between cytogenetic and molecular findings in human chronic myelogenous leukemia lines EM-2 and EM-3.
Cancer Genet. Cytogenet. 25:271-284(1987)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Armand Keating;
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Hans Gunther Drexler, Roderick A.F. MacLeod, Cord C. Uphoff;
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Cord C. Uphoff, Silke Habig, Severine Fombonne, Yoshinobu Matsuo, Hans Gunther Drexler;
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

PubMed=10637496; DOI=10.1038/sj.leu.2401604
Hans Gunther Drexler, Severine Fombonne, Yoshinobu Matsuo, Z.-B. Hu, Hiroyuki Hamaguchi, Cord C. Uphoff;
p53 alterations in human leukemia-lymphoma cell lines: in vitro artifact or prerequisite for cell immortalization?
Leukemia 14:198-206(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Anna K. Hagstrom-Andersson, Patrik Eden, David Lindgren, Jens Nilsson, Carin Lassen, Jesper Heldrup, Magnus Fontes, Ake Borg, Felix Mitelman, Bertil Johansson, Mattias Hoglund, Thoas Fioretos;
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line collections (Providers) DSMZ; ACC-134
Cell line databases/resources CLO; CLO_0002923
CLDB; cl1165
Cell_Model_Passport; SIDM01046
DSMZCellDive; ACC-134
Anatomy/cell type resources BTO; BTO_0005905
Encyclopedic resources Wikidata; Q54832265
Polymorphism and mutation databases Cosmic; 787492
Cosmic; 798662
Cosmic; 994179
Cosmic; 1026571
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number24