ID   EM-3
AC   CVCL_2033
SY   EM3
DR   BTO; BTO_0005905
DR   CLO; CLO_0002923
DR   CLDB; cl1165
DR   Cell_Model_Passport; SIDM01046
DR   Cosmic; 787492
DR   Cosmic; 798662
DR   Cosmic; 994179
DR   Cosmic; 1026571
DR   DSMZ; ACC-134
DR   DSMZCellDive; ACC-134
DR   Wikidata; Q54832265
RX   CelloPub=CLPUB00038;
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=3030532;
RX   PubMed=3332852;
RX   PubMed=3856862;
RX   PubMed=10071072;
RX   PubMed=10576511;
RX   PubMed=10637496;
RX   PubMed=15843827;
RX   PubMed=25877200;
CC   Population: Caucasian.
CC   Doubling time: 2 days (CelloPub=CLPUB00038); ~40 hours (DSMZ=ACC-134).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511; PubMed=15843827).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): DSMZ=ACC-134; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 9,12
ST   D16S539: 11,12
ST   D18S51: 13
ST   D19S433: 15,16
ST   D21S11: 30
ST   D2S1338: 22,24
ST   D3S1358: 14,16
ST   D5S818: 8,12
ST   D7S820: 10
ST   D8S1179: 14
ST   FGA: 21,22
ST   Penta D: 13,14
ST   Penta E: 7,16
ST   TH01: 9.3
ST   TPOX: 8,12
ST   vWA: 14,17
DI   NCIt; C7320; Childhood chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1196 ! EM-2
SX   Female
AG   5Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 24
//
RX   PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9;
RA   Uphoff, Cord C.
RA   Habig, Silke
RA   Fombonne, Severine
RA   Matsuo, Yoshinobu
RA   Drexler, Hans Gunther
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=15843827; DOI=10.1038/sj.leu.2403749;
RA   Hagstrom-Andersson, Anna K.
RA   Eden, Patrik
RA   Lindgren, David
RA   Nilsson, Jens
RA   Lassen, Carin
RA   Heldrup, Jesper
RA   Fontes, Magnus
RA   Borg, Ake
RA   Mitelman, Felix
RA   Johansson, Bertil
RA   Hoglund, Mattias
RA   Fioretos, Thoas
RT   "Gene expression profiling of leukemic cell lines reveals conserved
RT   molecular signatures among subtypes with specific genetic
RT   aberrations.";
RL   Leukemia 19:1042-1050(2005).
//
RX   PubMed=3030532; DOI=10.1016/0165-4608(87)90188-9;
RA   Raskind, Wendy Herlihy
RA   Disteche, Christine M.
RA   Keating, Armand
RA   Singer, Jack W.
RT   "Correlation between cytogenetic and molecular findings in human
RT   chronic myelogenous leukemia lines EM-2 and EM-3.";
RL   Cancer Genet. Cytogenet. 25:271-284(1987).
//
RX   PubMed=3856862; DOI=10.1073/pnas.82.6.1810; PMCID=PMC397362;
RA   Konopka, James B.
RA   Watanabe, Susan M.
RA   Singer, Jack W.
RA   Collins, Steven J.
RA   Witte, Owen Neil
RT   "Cell lines and clinical isolates derived from Ph1-positive chronic
RT   myelogenous leukemia patients express c-abl proteins with a common
RT   structural alteration.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:1810-1814(1985).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler, Hans Gunther
RA   MacLeod, Roderick A.F.
RA   Uphoff, Cord C.
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10637496; DOI=10.1038/sj.leu.2401604;
RA   Drexler, Hans Gunther
RA   Fombonne, Severine
RA   Matsuo, Yoshinobu
RA   Hu, Zhen-Bo
RA   Hamaguchi, Hiroyuki
RA   Uphoff, Cord C.
RT   "p53 alterations in human leukemia-lymphoma cell lines: in
RT   vitro artifact or prerequisite for cell immortalization?";
RL   Leukemia 14:198-206(2000).
//
RX   CelloPub=CLPUB00038;
RA   Keating, Armand
RA   Martin, Paul Joseph
RA   Bernstein, Irwin David
RA   Papayannopoulou, Thalia
RA   Raskind, Wendy Herlihy
RA   Singer, Jack W.
RT   "EM-2 and EM-3: two new Ph1+ myeloid cell lines.";
RL   (In book chapter) Normal and neoplastic hematopoiesis, UCLA symposia on molecular and cellular biology, New Series Vol. 9; Golde, David W. & Marks, Paul Alan (eds.); pp.513-520; Alan R. Liss; New York; USA (1983).
//
RX   PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9;
RA   Keating, Armand
RT   "Ph positive CML cell lines.";
RL   Baillieres Clin. Haematol. 1:1021-1029(1987).
//