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Cellosaurus HSB2/GS (CVCL_1Y12)

[Text version]
Cell line name HSB2/GS
Synonyms HSB2 / GS; HSB2 HHV6A (GS); HSB2/HHV6A
Accession CVCL_1Y12
Resource Identification Initiative To cite this cell line use: HSB2/GS (RRID:CVCL_1Y12)
Comments Population: Caucasian.
Virology: Infected with human herpesvirus 6A (HHV-6A) strain GS (PubMed=1653487).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:10879; STIL + HGNC; HGNC:11556; TAL1; Name(s)=STIL-TAL1, SIL-TAL1, SIL-SCL (from parent cell line).
  • Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Pro1175Arg (c.3524C>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Tyr226His (c.676T>C); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Arg621His (c.1862G>A); ClinVar=VCV000016355; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Thr454Ile (c.1361C>T); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Gln455Lys (c.1363C>A); Zygosity=Unspecified (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1859 (CCRF-HSB-2)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
Web pages Provider; HHV-6 Foundation; -; https://hhv-6foundation.org/wp-content/uploads/2016/12/hhv-6a-gs-strain-in-hsb2-cell-line.pdf
Publications

PubMed=1653487; DOI=10.1016/0042-6822(91)90424-A
Ablashi D.V., Balachandran N., Josephs S.F., Hung C.-L., Krueger G.R.F., Kramarsky B., Salahuddin S.Z., Gallo R.C.
Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates.
Virology 184:545-552(1991)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-350
Cell line databases/resources cancercelllines; CVCL_1Y12
Encyclopedic resources Wikidata; Q54896366
Entry history
Entry creation22-Sep-2015
Last entry update10-Apr-2025
Version number17