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Cellosaurus 222 (CVCL_1T15)

[Text version]
Cell line name 222
Accession CVCL_1T15
Resource Identification Initiative To cite this cell line use: 222 (RRID:CVCL_1T15)
Comments Problematic cell line: Contaminated. Shown to be a PA-1 derivative (PubMed=22710073). Originally thought to be an ovarian carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00454.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro316Pro (c.948C>T); ClinVar=VCV000750727; Zygosity=Heterozygous (PubMed=8557231).
Disease Ovarian mixed germ cell tumor (NCIt: C8114)
Mixed germ cell tumor (ORDO: Orphanet_180234)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0479 (PA-1)
Children:
CVCL_1T16 (222TR)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=2227544; DOI=10.1016/0090-8258(90)90068-V
Benjamin Bonavida, Toshiharu Tsuchitani, Jacob Zighelboim, Jonathan S. Berek;
Synergy is documented in vitro with low-dose recombinant tumor necrosis factor, cisplatin, and doxorubicin in ovarian cancer cells.
Gynecol. Oncol. 38:333-339(1990)

PubMed=1918981; DOI=10.4049/jimmunol.147.8.2609
Hideki Morimoto, Jeffrey T. Safrit, Benjamin Bonavida;
Synergistic effect of tumor necrosis factor-alpha- and diphtheria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines.
J. Immunol. 147:2609-2616(1991)

PubMed=8557231; DOI=10.1006/gyno.1996.0014
Jeffrey S. Skilling, Robert C. Squatrito, Joseph P. Connor, Theodore Niemann, Richard E. Buller;
p53 gene mutation analysis and antisense-mediated growth inhibition of human ovarian carcinoma cell lines.
Gynecol. Oncol. 60:72-80(1996)

PubMed=9554442; DOI=10.1093/jnci/90.8.597
Anita Lyn Sabichi, Denver T. Hendricks, Mary A. Bober, Michael J. Birrer;
Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide.
J. Natl. Cancer Inst. 90:597-605(1998)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1T15
Anatomy/cell type resources BTO; BTO_0004035
Biological sample resources BioSample; SAMN03151885
Encyclopedic resources Wikidata; Q54583269
Polymorphism and mutation databases IARC_TP53; 5549
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number21