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Cellosaurus 222 (CVCL_1T15)

[Text version]
Cell line name 222
Accession CVCL_1T15
Resource Identification Initiative To cite this cell line use: 222 (RRID:CVCL_1T15)
Comments Problematic cell line: Contaminated. Shown to be a PA-1 derivative (PubMed=22710073). Originally thought to be an ovarian carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00454.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro316Pro (c.948C>T); ClinVar=VCV000750727; Zygosity=Heterozygous (PubMed=8557231).
Disease Ovarian mixed germ cell tumor (NCIt: C8114)
Mixed germ cell tumor (ORDO: Orphanet_180234)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0479 (PA-1)
CVCL_1T16 (222TR)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=2227544; DOI=10.1016/0090-8258(90)90068-V
Bonavida B., Tsuchitani T., Zighelboim J., Berek J.S.
Synergy is documented in vitro with low-dose recombinant tumor necrosis factor, cisplatin, and doxorubicin in ovarian cancer cells.
Gynecol. Oncol. 38:333-339(1990)

PubMed=1918981; DOI=10.4049/jimmunol.147.8.2609
Morimoto H., Safrit J.T., Bonavida B.
Synergistic effect of tumor necrosis factor-alpha- and diphtheria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines.
J. Immunol. 147:2609-2616(1991)

PubMed=8557231; DOI=10.1006/gyno.1996.0014
Skilling J.S., Squatrito R.C., Connor J.P., Niemann T., Buller R.E.
p53 gene mutation analysis and antisense-mediated growth inhibition of human ovarian carcinoma cell lines.
Gynecol. Oncol. 60:72-80(1996)

PubMed=9554442; DOI=10.1093/jnci/90.8.597
Sabichi A.L., Hendricks D.T., Bober M.A., Birrer M.J.
Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide.
J. Natl. Cancer Inst. 90:597-605(1998)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cell line databases/resources cancercelllines; CVCL_1T15
Anatomy/cell type resources BTO; BTO:0004035
Biological sample resources BioSample; SAMN03151885
Encyclopedic resources Wikidata; Q54583269
Polymorphism and mutation databases IARC_TP53; 5549
Entry history
Entry creation08-Jul-2015
Last entry update02-May-2024
Version number19