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Cellosaurus 222TR (CVCL_1T16)

[Text version]
Cell line name 222TR
Accession CVCL_1T16
Resource Identification Initiative To cite this cell line use: 222TR (RRID:CVCL_1T16)
Comments Problematic cell line: Contaminated. Parent cell line (222) has been shown to be a PA-1 derivative.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro316Pro (c.948C>T); ClinVar=VCV000750727; Zygosity=Heterozygous (from parent cell line).
Disease Ovarian mixed germ cell tumor (NCIt: C8114)
Mixed germ cell tumor (ORDO: Orphanet_180234)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1T15 (222)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line

PubMed=1918981; DOI=10.4049/jimmunol.147.8.2609
Morimoto H., Safrit J.T., Bonavida B.
Synergistic effect of tumor necrosis factor-alpha- and diphtheria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines.
J. Immunol. 147:2609-2616(1991)

Cell line databases/resources cancercelllines; CVCL_1T16
Encyclopedic resources Wikidata; Q54583273
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number12