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Cellosaurus AtT-20ins (CVCL_1G40)

[Text version]
Cell line name AtT-20ins
Synonyms AtT-20 ins
Accession CVCL_1G40
Resource Identification Initiative To cite this cell line use: AtT-20ins (RRID:CVCL_1G40)
Comments Characteristics: Expression of INS is driven by the RSV LTR (PubMed=1309953).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pituitary gland; UBERON=UBERON_0000007.
Disease Mouse pituitary gland neoplasms (NCIt: C24037)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: LAF1.
Hierarchy Parent: CVCL_2300 (AtT-20)
Children:
CVCL_F0KU (AtT-20ins hGLUT-1 1-12)CVCL_F0KR (AtT-20ins hGLUT-1 1-2)CVCL_F0KS (AtT-20ins hGLUT-1 1-5)
CVCL_F0KT (AtT-20ins hGLUT-1 1-8)CVCL_F0KV (AtT-20ins hGLUT-1 2-10)CVCL_F0KQ (CGT-5)
CVCL_6566 (CGT-6)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=1309953; DOI=10.1073/pnas.89.2.688; PMCID=PMC48304
Steven D. Hughes, John H. Johnson, Christian Quaade, Christopher Bang Newgard;
Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells.
Proc. Natl. Acad. Sci. U.S.A. 89:688-692(1992)

PubMed=8325893; DOI=10.1016/S0021-9258(18)82457-7
Steven D. Hughes, Christian Quaade, John H. Johnson, Sarah Ferber, Christopher Bang Newgard;
Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism.
J. Biol. Chem. 268:15205-15212(1993)

PubMed=8433987; DOI=10.1073/pnas.90.4.1281; PMCID=PMC45856
Lindsey R. Inman, Chris T. McAllister, Ling Chen, Steven D. Hughes, Christopher Bang Newgard, John R. Kettman, Roger Harold Unger, John H. Johnson;
Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset.
Proc. Natl. Acad. Sci. U.S.A. 90:1281-1284(1993)

PubMed=8697299
Vincent Poitout, Lawrence Karl Olson, R. Paul Robertson;
Insulin-secreting cell lines: classification, characteristics and potential applications.
Diabetes Metab. 22:7-14(1996)

Cross-references
Encyclopedic resources Wikidata; Q54751303
Entry history
Entry creation08-Jul-2015
Last entry update14-Aug-2025
Version number10