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Cellosaurus CGT-6 (CVCL_6566)

[Text version]
Cell line name CGT-6
Synonyms AtT-20ins (CGT-6); CGT6
Accession CVCL_6566
Resource Identification Initiative To cite this cell line use: CGT-6 (RRID:CVCL_6566)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11285.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
Genetic integration: Method=Transfection; Gene=RGD; 3705; Slc2a2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pituitary gland; UBERON=UBERON_0000007.
Disease Mouse pituitary gland neoplasms (NCIt: C24037)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: LAF1.
Hierarchy Parent: CVCL_1G40 (AtT-20ins)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=1309953; DOI=10.1073/pnas.89.2.688; PMCID=PMC48304
Steven D. Hughes, John H. Johnson, Christian Quaade, Christopher Bang Newgard;
Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells.
Proc. Natl. Acad. Sci. U.S.A. 89:688-692(1992)

PubMed=8325893; DOI=10.1016/S0021-9258(18)82457-7
Steven D. Hughes, Christian Quaade, John H. Johnson, Sarah Ferber, Christopher Bang Newgard;
Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism.
J. Biol. Chem. 268:15205-15212(1993)

PubMed=8433987; DOI=10.1073/pnas.90.4.1281; PMCID=PMC45856
Lindsey R. Inman, Chris T. McAllister, Ling Chen, Steven D. Hughes, Christopher Bang Newgard, John R. Kettman, Roger Harold Unger, John H. Johnson;
Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset.
Proc. Natl. Acad. Sci. U.S.A. 90:1281-1284(1993)

Patent=US5427940
Christopher Bang Newgard;
Engineered cells producing insulin in response to glucose.
Patent number US5427940, 27-Jun-1995

Cross-references
Cell line collections (Providers) ATCC; CRL-11285 - Discontinued
Cell line databases/resources CLO; CLO_0001768
Encyclopedic resources Wikidata; Q54811587
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number12