Cellosaurus cell line HROC69 T0 M2 (CVCL

Cellosaurus HROC69 T0 M2 (CVCL_1G07)

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Cell line name

HROC69 T0 M2

Synonyms

HROC69X

Accession

CVCL_1G07

Resource Identification Initiative

To cite this cell line use: HROC69 T0 M2 (RRID:CVCL_1G07)

Comments

From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
Population: Caucasian.
Characteristics: Established from a patient-derived xenograft established in female NMRI nu/nu mice.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.

Sequence variations

Mutation; HGNC; HGNC:583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Unspecified (PubMed=27087592).
Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu7Ter (c.19G>T); ClinVar=VCV000493079; Zygosity=Unspecified (PubMed=27087592).
Mutation; HGNC; HGNC:6769; SMAD3; Simple; p.Ala382Val (c.1145C>T); ClinVar=VCV001677493; Zygosity=Unspecified (PubMed=27087592).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=27087592).

HLA typing

Source: Direct_author_submission

Class I
HLA-A	A*26:01,33:01
HLA-B	B*18:01,52:01
HLA-C	C*12:02,12:03
Class II
HLA-DQ	DQB1*03:01,06:01
HLA-DR	DRB1*11:04,15:02

Disease

Colon adenocarcinoma (NCIt: C4349)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_YD53 ! B-LCL-HROC69
CVCL_1G06 ! HROC69

Sex of cell

Male

Age at sampling

62Y

Category

Cancer cell line

STR profile

Source(s): CLS=300829; PubMed=27087592

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D5S818	12,13
D7S820	10,12
D13S317	12
D16S539	12,13
TH01	7,10
TPOX	8,12
vWA	17

Publications

PubMed=27087592; DOI=10.1038/srep24671; PMCID=PMC4834534
Florian Kuehn, Christina Susanne Mullins, Mathias Krohn, Christine Harnack, Robert Ramer, Oliver H. Kramer, Ernst Klar, Maja Huhns, Michael Linnebacher;
Establishment and characterization of HROC69 -- a Crohn s related colonic carcinoma cell line and its matched patient-derived xenograft.
Sci. Rep. 6:24671.1-24671.10(2016)

PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890
Christina Susanne Mullins, Bianca Micheel, Stephanie Matschos, Matthias Leuchter, Florian Burtin, Mathias Krohn, Maja Huhns, Ernst Klar, Friedrich Prall, Michael Linnebacher;
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references

Cell line collections (Providers)

CLS; 300829

Cell line databases/resources

cancercelllines; CVCL_1G07

Encyclopedic resources

Wikidata; Q54895302

Polymorphism and mutation databases

Cosmic; 2795027

Entry history

Entry creation

08-Jul-2015

Last entry update

27-Nov-2025

Version number