ID   HROC69 T0 M2
AC   CVCL_1G07
SY   HROC69X
DR   cancercelllines; CVCL_1G07
DR   CLS; 300829
DR   Cosmic; 2795027
DR   Wikidata; Q54895302
RX   PubMed=27087592;
RX   PubMed=31601052;
CC   From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
CC   Population: Caucasian.
CC   Characteristics: Established from a patient-derived xenograft established in female NMRI nu/nu mice.
CC   HLA typing: A*26:01,33:01; B*18:01,52:01; C*12:02,12:03; DQB1*03:01,06:01; DRB1*11:04,15:02 (Direct_author_submission).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Unspecified (PubMed=27087592).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu7Ter (c.19G>T); ClinVar=VCV000493079; Zygosity=Unspecified (PubMed=27087592).
CC   Sequence variation: Mutation; HGNC; HGNC:6769; SMAD3; Simple; p.Ala382Val (c.1145C>T); dbSNP=rs779602560; Zygosity=Unspecified (PubMed=27087592).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=27087592).
CC   Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
ST   Source(s): CLS=300829; PubMed=27087592
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 12
ST   D16S539: 12,13
ST   D5S818: 12,13
ST   D7S820: 10,12
ST   TH01: 7,10
ST   TPOX: 8,12
ST   vWA: 17
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_YD53 ! B-LCL-HROC69
OI   CVCL_1G06 ! HROC69
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 20
//
RX   PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890;
RA   Mullins, Christina Susanne
RA   Micheel, Bianca
RA   Matschos, Stephanie
RA   Leuchter, Matthias
RA   Burtin, Florian
RA   Krohn, Mathias
RA   Huhns, Maja
RA   Klar, Ernst
RA   Prall, Friedrich
RA   Linnebacher, Michael
RT   "Integrated biobanking and tumor model establishment of human
RT   colorectal carcinoma provides excellent tools for preclinical
RT   research.";
RL   Cancers (Basel) 11:1520.1-1520.18(2019).
//
RX   PubMed=27087592; DOI=10.1038/srep24671; PMCID=PMC4834534;
RA   Kuehn, Florian
RA   Mullins, Christina Susanne
RA   Krohn, Mathias
RA   Harnack, Christine
RA   Ramer, Robert
RA   Kramer, Oliver H.
RA   Klar, Ernst
RA   Huhns, Maja
RA   Linnebacher, Michael
RT   "Establishment and characterization of HROC69 -- a Crohn s related
RT   colonic carcinoma cell line and its matched patient-derived
RT   xenograft.";
RL   Sci. Rep. 6:24671-24671(2016).
//