ID   HROC69 T0 M2
AC   CVCL_1G07
SY   HROC69X
DR   cancercelllines; CVCL_1G07
DR   CLS; 300829
DR   Cosmic; 2795027
DR   Wikidata; Q54895302
RX   PubMed=27087592;
RX   PubMed=31601052;
CC   From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
CC   Population: Caucasian.
CC   Characteristics: Established from a patient-derived xenograft established in female NMRI nu/nu mice.
CC   HLA typing: A*26:01,33:01; B*18:01,52:01; C*12:02,12:03; DQB1*03:01,06:01; DRB1*11:04,15:02 (Direct_author_submission).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Unspecified (PubMed=27087592).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu7Ter (c.19G>T); ClinVar=VCV000493079; Zygosity=Unspecified (PubMed=27087592).
CC   Sequence variation: Mutation; HGNC; HGNC:6769; SMAD3; Simple; p.Ala382Val (c.1145C>T); dbSNP=rs779602560; Zygosity=Unspecified (PubMed=27087592).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=27087592).
CC   Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
ST   Source(s): CLS=300829; PubMed=27087592
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 12
ST   D16S539: 12,13
ST   D5S818: 12,13
ST   D7S820: 10,12
ST   TH01: 7,10
ST   TPOX: 8,12
ST   vWA: 17
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_YD53 ! B-LCL-HROC69
OI   CVCL_1G06 ! HROC69
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 20
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RX   PubMed=27087592; DOI=10.1038/srep24671; PMCID=PMC4834534;
RA   Kuehn F., Mullins C.S., Krohn M., Harnack C., Ramer R., Kramer O.H.,
RA   Klar E., Huhns M., Linnebacher M.;
RT   "Establishment and characterization of HROC69 -- a Crohn s related
RT   colonic carcinoma cell line and its matched patient-derived
RT   xenograft.";
RL   Sci. Rep. 6:24671-24671(2016).
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RX   PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890;
RA   Mullins C.S., Micheel B., Matschos S., Leuchter M., Burtin F.,
RA   Krohn M., Huhns M., Klar E., Prall F., Linnebacher M.;
RT   "Integrated biobanking and tumor model establishment of human
RT   colorectal carcinoma provides excellent tools for preclinical
RT   research.";
RL   Cancers (Basel) 11:1520.1-1520.18(2019).
//