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Cellosaurus HPB-ALL (CVCL_1820)

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Cell line name HPB-ALL
Synonyms HPB/ALL; HPBALL; FCCH1018
Accession CVCL_1820
Resource Identification Initiative To cite this cell line use: HPB-ALL (RRID:CVCL_1820)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Population: Japanese.
Doubling time: ~50 hours (DSMZ=ACC-483).
Microsatellite instability: Instable (MSI) (PubMed=10739008; PubMed=11226526; PubMed=31068700).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:1539; CBFB + HGNC; HGNC:29824; MYL11; Name(s)=CBFB-MYL11, CBFB-MYLPF (PubMed=31160637).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465His (c.1394G>A); ClinVar=VCV000376415; Zygosity=Unspecified (PubMed=22675565).
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Ala134Ser (c.400G>T); Zygosity=Unspecified (PubMed=22675565).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1574Pro (c.4721T>C); Zygosity=Heterozygous (PubMed=15472075).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Asp2442fs*39 (c.7326_7326insGGGCCGTGGACG); Zygosity=Heterozygous (PubMed=15472075).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg159Ser (c.477G>T); ClinVar=VCV000375959; Zygosity=Unspecified (PubMed=22675565).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys124Ter (c.372C>A); ClinVar=VCV000458537; Zygosity=Homozygous (PubMed=16142349; DepMap=ACH-000942).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=22675565).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Ser121Ter (c.362C>A); Zygosity=Unspecified (PubMed=22675565).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*15:07,52:01
HLA-CC*03:03,12:02

Source: DSMZCellDive=ACC-483
Class I
HLA-AA*24:02:01,24:02:01
HLA-BB*15:07:01,52:01:01
HLA-CC*03:03:01,12:02:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North78.04
East Asian, South20.81
South Asian1.14
European, North0
European, South0
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E8AT (HPB-Ma)CVCL_7959 (HPB-MLT)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-483; RCB=RCB1935; TKG=TKG 0199

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133821
D3S135817
D5S81811
D7S82011
D8S117911,12
D13S3178,10
D16S5399,11
D18S5115,19
D19S43313,14
D21S1130
FGA19,23
Penta D9,11
Penta E10,15
TH017,9
TPOX8,12
vWA18,20

Run an STR similarity search on this cell line
Web pages Info; T-ALL cell lines db; -; https://humantallcelllines.wordpress.com/comprehensivetable/hpb-all/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-55.html
Publications

PubMed=203546; DOI=10.1002/ijc.2910210207
Shigeru Morikawa, Eiji Tatsumi, Mitsuo Baba, Takayuki Harada, Kimio Yasuhira;
Two E-rosette-forming lymphoid cell lines.
Int. J. Cancer 21:166-170(1978)

PubMed=6181032; DOI=10.1016/0198-8859(82)90037-4
Ruth Rabinowitz, J. Weinstock, Ehud J. Margalioth, Hannah Ben-Bassat, Michael Schlesinger;
Antigens specific for human T-lymphocytes detected by xenoantisera to HD-MAR cells: their differential expression on various T-cell lines.
Hum. Immunol. 4:219-228(1982)

PubMed=6749281; DOI=10.1002/1097-0142(19821101)50:9<1775::AID-CNCR2820500922>3.0.CO;2-T
Susumu Kanazawa, Shigeru Morikawa, Takayuki Harada, Kimio Yasuhira, Yoshito Matsubara, Sadao Ikeda, Seitaku Soeda, Masaki Fujimura;
Carcinoembryonic antigen producing cultured cell lines enable detection of autoantibodies in sera from patients with gastrointestinal cancer.
Cancer 50:1775-1782(1982)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Akinobu Nakano, Takayuki Harada, Shigeru Morikawa, Yuzuru Kato;
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=1373528
Da-Shuhn Duan, Wayne Smith, Wolfgang Sadee, Morton J. Cowan;
Characterization of three T-lymphoid cell lines with distinct sensitivities to deoxyadenosine plus deoxycoformycin.
Thymus 19:1-11(1992)

PubMed=8127147
Mats Heyman, Dan Grander, Karen Brondum-Nielsen, Britta Cederblad, Yie Liu, Bo Xu, Stefan Einhorn;
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x
Laura Borgonovo-Brandter, Mats Heyman, Omid Rasool, Y. Liu, Dan Grander, Stefan Einhorn;
p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.
Eur. J. Haematol. 56:313-318(1996)

PubMed=8957066; DOI=10.1111/j.1349-7006.1996.tb03112.x; PMCID=PMC5920998
Nobuhiro Kawasaki, Yoshinobu Matsuo, Tadashi Yoshino, Hiroyuki Yanai, Takashi Oka, Norihiro Teramoto, Cao Liu, Eisaku Kondo, Jun Minowada, Tadaatsu Akagi;
Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.
Jpn. J. Cancer Res. 87:1070-1077(1996)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Renate Burger, Thomas E. Hansen-Hagge, Hans Gunther Drexler, Martin Gramatzki;
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=12661009; DOI=10.1002/gcc.10194
Roderick A.F. MacLeod, Stefan Nagel, Maren Kaufmann, Johannes W.G. Janssen, Hans Gunther Drexler;
Activation of HOX11L2 by juxtaposition with 3'-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2).
Genes Chromosomes Cancer 37:84-91(2003)

PubMed=15472075; DOI=10.1126/science.1102160
Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee, John P. Morris 4th, Lewis B. Silverman, Cheryll Sanchez-Irizarry, Stephen Charles Blacklow, Alfred Thomas Look, Jon Christopher Aster;
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=16142349; DOI=10.3892/or.14.4.901
Jana Smardova, Sarka Pavlova, Miluska Svitakova, Diana Grochova, Barbora Ravcukova;
Analysis of p53 status in human cell lines using a functional assay in yeast: detection of new non-sense p53 mutation in codon 124.
Oncol. Rep. 14:901-907(2005)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Yorick Sandberg, Brenda Verhaaf, Ellen J. van Gastel-Mol, Ingrid L.M. Wolvers-Tettero, John De Vos, Roderick A.F. MacLeod, Jeroen G. Noordzij, Willem A. Dik, Jack J.M. van Dongen, Anton W. Langerak;
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22675565; DOI=10.1371/journal.pone.0038463; PMCID=PMC3366948
Zeynep Kalender Atak, Kim De Keersmaecker, Valentina Gianfelici, Ellen Geerdens, Roel Vandepoel, Daphnie Pauwels, Michael Porcu, Idoya Lahortiga, Vanessa Brys, Wilhelm Gerhard Dirks, Hilmar Quentmeier ...Show all 17 authors... , Jacqueline Cloos, Harry Cuppens, Anne Uyttebroeck, Peter Vandenberghe, Jan Cools, Stein Aerts; Show fewer authors
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:e38463.1-e38463.11(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Paivi Ostling ...Show all 17 authors... , Olli-Pekka Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtio, Mattias Vesterlund, Rozbeh Jafari; Show fewer authors
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-483
NCBI_Iran; C213
RCB; RCB1935
TKG; TKG 0199
Cell line databases/resources CLO; CLO_0003817
CLO; CLO_0050988
cancercelllines; CVCL_1820
Cell_Model_Passport; SIDM01618
DepMap; ACH-000942
DSMZCellDive; ACC-483
Lonza; 250
Anatomy/cell type resources BTO; BTO_0001952
Biological sample resources BioSample; SAMN01821632
BioSample; SAMN03473562
BioSample; SAMN10988462
Chemistry resources ChEMBL-Cells; CHEMBL4295419
ChEMBL-Targets; CHEMBL4296435
PharmacoDB; HPBALL_566_2019
PubChem_Cell_line; CVCL_1820
Encyclopedic resources Wikidata; Q54890235
Experimental variables resources EFO; EFO_0022458
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
FANTOM5_SSTAR; 10429-106D6
GEO; GSM887091
GEO; GSM888162
GEO; GSM5137717
Polymorphism and mutation databases Cosmic; 801726
Cosmic; 913406
Cosmic; 919159
Cosmic; 933550
Cosmic; 998736
Cosmic; 999754
Cosmic; 1037689
Cosmic; 1115583
Cosmic; 1130235
Cosmic; 1151779
Cosmic; 1224373
Cosmic; 1281368
Cosmic; 1330499
Cosmic; 1524796
Cosmic; 1641378
Cosmic; 1664521
Cosmic; 1760522
Cosmic; 2165711
Cosmic; 2602914
IARC_TP53; 21703
LiGeA; CCLE_898
Progenetix; CVCL_1820
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39