Cellosaurus logo
expasy logo

Cellosaurus HPB-MLT (CVCL_7959)

[Text version]
Cell line name HPB-MLT
Synonyms FCCH1019
Accession CVCL_7959
Resource Identification Initiative To cite this cell line use: HPB-MLT (RRID:CVCL_7959)
Comments Problematic cell line: Contaminated. Shown to be a HPB-ALL derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from a 62 year old female patient with a T-cell lymphoid malignancy.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00212.
Population: Japanese.
Misspelling: MPB-MLT; PubMed=10071127.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:1539; CBFB + HGNC; HGNC:29824; MYL11; Name(s)=CBFB-MYL11, CBFB-MYLPF (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1574Pro (c.4721T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Asp2442fs*39 (c.7326_7326insGGGCCGTGGACG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys124Ter (c.372C>A); ClinVar=VCV000458537; Zygosity=Homozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1820 (HPB-ALL)
Children:
CVCL_UJ09 (HPB/ADR)CVCL_UJ10 (HPB/VP-16)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): TKG=TKG 0361

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81811
D7S82011
D13S3178,10
D16S5399,11
TH017,9
TPOX8,12
vWA18,20

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=203546; DOI=10.1002/ijc.2910210207
Shigeru Morikawa, Eiji Tatsumi, Mitsuo Baba, Takayuki Harada, Kimio Yasuhira;
Two E-rosette-forming lymphoid cell lines.
Int. J. Cancer 21:166-170(1978)

PubMed=6749281; DOI=10.1002/1097-0142(19821101)50:9<1775::AID-CNCR2820500922>3.0.CO;2-T
Susumu Kanazawa, Shigeru Morikawa, Takayuki Harada, Kimio Yasuhira, Yoshito Matsubara, Sadao Ikeda, Seitaku Soeda, Masaki Fujimura;
Carcinoembryonic antigen producing cultured cell lines enable detection of autoantibodies in sera from patients with gastrointestinal cancer.
Cancer 50:1775-1782(1982)

PubMed=6198871; DOI=10.18926/AMO/32400
Takuzo Oda, Sekiko Watanabe, Takashi Nakamura;
Type C virus particles produced in human T-cell lines derived from acute lymphoblastic leukemia and a leukemic T-lymphoid malignancy.
Acta Med. Okayama 37:529-533(1983)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Akinobu Nakano, Takayuki Harada, Shigeru Morikawa, Yuzuru Kato;
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=1370437; DOI=10.1002/ijc.2910500223
Robin Strong Treichel, Sarah Olken;
The relationship between multi-drug resistance and resistance to natural-killer-cell and lymphokine-activated killer-cell lysis in human leukemic cell lines.
Int. J. Cancer 50:305-310(1992)

PubMed=1373528
Da-Shuhn Duan, Wayne Smith, Wolfgang Sadee, Morton J. Cowan;
Characterization of three T-lymphoid cell lines with distinct sensitivities to deoxyadenosine plus deoxycoformycin.
Thymus 19:1-11(1992)

PubMed=8099376; DOI=10.1016/0145-2126(93)90124-4
Robin Strong Treichel;
Autologous bone marrow transplantation for leukemia: monoclonal antibody-mediated purging of multidrug-resistant leukemia.
Leuk. Res. 17:491-499(1993)

PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5
Machiko Kawamura, Hiroaki Ohnishi, Shu-Xia Guo, Xiao-Ming Sheng, Masayoshi Minegishi, Ryoji Hanada, Keizo Horibe, Teruaki Hongo, Yasuhiko Kaneko, Fumio Bessho, Masayoshi Yanagisawa ...Show all 13 authors... , Takao Sekiya, Yasuhide Hayashi; Show fewer authors
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.
Leuk. Res. 23:115-126(1999)

PubMed=10849313; DOI=10.1046/j.1440-1827.2000.01040.x
Makoto Nagasaki, Shigeru Morikawa, Ikuko Torii, Jie Zhang, Keiko Morikawa;
A human B-lineage dendritic cell line, HBM-Noda and its potential role in human T-cell leukemia/lymphoma virus type I infection.
Pathol. Int. 50:280-290(2000)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod;
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) RCB; RCB1937 - Discontinued
TKG; TKG 0361
Cell line databases/resources cancercelllines; CVCL_7959
Biological sample resources BioSample; SAMN03151780
Encyclopedic resources Wikidata; Q54890237
Polymorphism and mutation databases Cosmic; 721703
Cosmic; 801733
Cosmic; 998731
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number31