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Cellosaurus HPB-MLT (CVCL_7959)

[Text version]
Cell line name HPB-MLT
Synonyms FCCH1019
Accession CVCL_7959
Resource Identification Initiative To cite this cell line use: HPB-MLT (RRID:CVCL_7959)
Comments Problematic cell line: Contaminated. Shown to be a HPB-ALL derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from a 62 year old female patient with a T-cell lymphoid malignancy.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00212.
Population: Japanese.
Misspelling: MPB-MLT; PubMed=10071127.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; 1539; CBFB + HGNC; 29824; MYL11; Name(s)=CBFB-MYL11, CBFB-MYLPF (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1574Pro (c.4721T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Asp2442fs*39 (c.7326_7326insGGGCCGTGGACG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys124Ter (c.372C>A); ClinVar=VCV000458537; Zygosity=Homozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1820 (HPB-ALL)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): TKG


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=203546; DOI=10.1002/ijc.2910210207
Morikawa S., Tatsumi E., Baba M., Harada T., Yasuhira K.
Two E-rosette-forming lymphoid cell lines.
Int. J. Cancer 21:166-170(1978)

PubMed=6749281; DOI=10.1002/1097-0142(19821101)50:9<1775::AID-CNCR2820500922>3.0.CO;2-T
Kanazawa S., Morikawa S., Harada T., Yasuhira K., Matsubara Y., Ikeda S., Soeda S., Fujimura M.
Carcinoembryonic antigen producing cultured cell lines enable detection of autoantibodies in sera from patients with gastrointestinal cancer.
Cancer 50:1775-1782(1982)

PubMed=6198871; DOI=10.18926/AMO/32400
Oda T., Watanabe S., Nakamura T.
Type C virus particles produced in human T-cell lines derived from acute lymphoblastic leukemia and a leukemic T-lymphoid malignancy.
Acta Med. Okayama 37:529-533(1983)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C.
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Nakano A., Harada T., Morikawa S., Kato Y.
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=1370437; DOI=10.1002/ijc.2910500223
Treichel R.S., Olken S.
The relationship between multi-drug resistance and resistance to natural-killer-cell and lymphokine-activated killer-cell lysis in human leukemic cell lines.
Int. J. Cancer 50:305-310(1992)

Duan D.-S., Smith W., Sadee W., Cowan M.J.
Characterization of three T-lymphoid cell lines with distinct sensitivities to deoxyadenosine plus deoxycoformycin.
Thymus 19:1-11(1992)

PubMed=8099376; DOI=10.1016/0145-2126(93)90124-4
Treichel R.S.
Autologous bone marrow transplantation for leukemia: monoclonal antibody-mediated purging of multidrug-resistant leukemia.
Leuk. Res. 17:491-499(1993)

PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5
Kawamura M., Ohnishi H., Guo S.X., Sheng X.-M., Minegishi M., Hanada R., Horibe K., Hongo T., Kaneko Y., Bessho F., Yanagisawa M., Sekiya T., Hayashi Y.
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.
Leuk. Res. 23:115-126(1999)

PubMed=10849313; DOI=10.1046/j.1440-1827.2000.01040.x
Nagasaki M., Morikawa S., Torii I., Zhang J., Morikawa K.
A human B-lineage dendritic cell line, HBM-Noda and its potential role in human T-cell leukemia/lymphoma virus type I infection.
Pathol. Int. 50:280-290(2000)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line collections (Providers) RCB; RCB1937 - Discontinued
TKG; TKG 0361
Cell line databases/resources cancercelllines; CVCL_7959
Biological sample resources BioSample; SAMN03151780
Encyclopedic resources Wikidata; Q54890237
Polymorphism and mutation databases Cosmic; 721703
Cosmic; 801733
Cosmic; 998731
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number28