ID HPB-ALL AC CVCL_1820 SY HPB/ALL; HPBALL; FCCH1018 DR BTO; BTO_0001952 DR CLO; CLO_0003817 DR CLO; CLO_0050988 DR EFO; EFO_0022458 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-7721 DR ArrayExpress; E-MTAB-7722 DR BioSample; SAMN01821632 DR BioSample; SAMN03473562 DR BioSample; SAMN10988462 DR cancercelllines; CVCL_1820 DR Cell_Model_Passport; SIDM01618 DR ChEMBL-Cells; CHEMBL4295419 DR ChEMBL-Targets; CHEMBL4296435 DR Cosmic; 801726 DR Cosmic; 913406 DR Cosmic; 919159 DR Cosmic; 933550 DR Cosmic; 998736 DR Cosmic; 999754 DR Cosmic; 1037689 DR Cosmic; 1115583 DR Cosmic; 1130235 DR Cosmic; 1151779 DR Cosmic; 1224373 DR Cosmic; 1281368 DR Cosmic; 1330499 DR Cosmic; 1524796 DR Cosmic; 1641378 DR Cosmic; 1664521 DR Cosmic; 1760522 DR Cosmic; 2165711 DR Cosmic; 2602914 DR DepMap; ACH-000942 DR DSMZ; ACC-483 DR DSMZCellDive; ACC-483 DR FANTOM5_SSTAR; 10429-106D6 DR GEO; GSM887091 DR GEO; GSM888162 DR GEO; GSM5137717 DR IARC_TP53; 21703 DR LiGeA; CCLE_898 DR Lonza; 250 DR NCBI_Iran; C213 DR PharmacoDB; HPBALL_566_2019 DR PRIDE; PXD023662 DR Progenetix; CVCL_1820 DR PubChem_Cell_line; CVCL_1820 DR RCB; RCB1935 DR TKG; TKG 0199 DR Wikidata; Q54890235 RX DOI=10.1016/B978-0-12-221970-2.50457-5; RX PubMed=203546; RX PubMed=1373528; RX PubMed=2140233; RX PubMed=2985879; RX PubMed=3159941; RX PubMed=3874327; RX PubMed=6181032; RX PubMed=6582512; RX PubMed=6749281; RX PubMed=8127147; RX PubMed=8641406; RX PubMed=8957066; RX PubMed=9510473; RX PubMed=9738977; RX PubMed=9933131; RX PubMed=10739008; RX PubMed=11226526; RX PubMed=12661009; RX PubMed=15472075; RX PubMed=16142349; RX PubMed=17170727; RX PubMed=22460905; RX PubMed=22675565; RX PubMed=26589293; RX PubMed=30285677; RX PubMed=30629668; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31160637; RX PubMed=35354797; WW Info; T-ALL cell lines db; -; https://humantallcelllines.wordpress.com/comprehensivetable/hpb-all/ WW Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-55.html CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: LL-100 blood cancer cell line panel. CC Population: Japanese. CC Doubling time: ~50 hours (DSMZ=ACC-483). CC HLA typing: A*24:02,24:02; B*15:07,52:01; C*03:03,12:02 (PubMed=26589293). CC HLA typing: A*24:02:01,24:02:01; B*15:07:01,52:01:01; C*03:03:01,12:02:02 (DSMZCellDive=ACC-483). CC Microsatellite instability: Instable (MSI) (PubMed=10739008; PubMed=11226526; PubMed=31068700). CC Sequence variation: Gene fusion; HGNC; HGNC:1539; CBFB + HGNC; HGNC:29824; MYL11; Name(s)=CBFB-MYL11, CBFB-MYLPF (PubMed=31160637). CC Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465His (c.1394G>A); ClinVar=VCV000376415; Zygosity=Unspecified (PubMed=22675565). CC Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Ala134Ser (c.400G>T); Zygosity=Unspecified (PubMed=22675565). CC Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1574Pro (c.4721T>C); Zygosity=Heterozygous (PubMed=15472075). CC Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Asp2442fs*39 (c.7326_7326insGGGCCGTGGACG); Zygosity=Heterozygous (PubMed=15472075). CC Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg159Ser (c.477G>T); ClinVar=VCV000375959; Zygosity=Unspecified (PubMed=22675565). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys124Ter (c.372C>A); ClinVar=VCV000458537; Zygosity=Homozygous (PubMed=16142349; DepMap=ACH-000942). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=22675565). CC Sequence variation: Mutation; HGNC; HGNC:12796; WT1; Simple; p.Ser121Ter (c.362C>A); Zygosity=Unspecified (PubMed=22675565). CC Omics: Genomics; Whole exome sequencing. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=78.04%; East Asian, South=20.81%; South Asian=1.14%; European, North=0%; European, South=0% (PubMed=30894373). CC Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. CC Cell type: T-cell; CL=CL_0000084. ST Source(s): DSMZ=ACC-483; RCB=RCB1935; TKG=TKG 0199 ST Amelogenin: X,Y ST CSF1PO: 10,11 ST D13S317: 8,10 ST D16S539: 9,11 ST D18S51: 15,19 ST D19S433: 13,14 ST D21S11: 30 ST D2S1338: 21 ST D3S1358: 17 ST D5S818: 11 ST D7S820: 11 ST D8S1179: 11,12 ST FGA: 19,23 ST Penta D: 9,11 ST Penta E: 10,15 ST TH01: 7,9 ST TPOX: 8,12 ST vWA: 18,20 DI NCIt; C7953; Childhood T acute lymphoblastic leukemia DI ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 14Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 39 CH CVCL_E8AT ! HPB-Ma CH CVCL_7959 ! HPB-MLT // RX PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7; RA Burger, Renate RA Hansen-Hagge, Thomas E. RA Drexler, Hans Gunther RA Gramatzki, Martin RT "Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: RT suggestion for classification by immunophenotype and T-cell receptor RT studies."; RL Leuk. Res. 23:19-27(1999). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. 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RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=17170727; DOI=10.1038/sj.leu.2404486; RA Sandberg, Yorick RA Verhaaf, Brenda RA van Gastel-Mol, Ellen J. RA Wolvers-Tettero, Ingrid L.M. RA De Vos, John RA MacLeod, Roderick A.F. RA Noordzij, Jeroen G. RA Dik, Willem A. RA van Dongen, Jacobus Johannes Maria RA Langerak, Anton W. RT "Human T-cell lines with well-defined T-cell receptor gene RT rearrangements as controls for the BIOMED-2 multiplex polymerase chain RT reaction tubes."; RL Leukemia 21:230-237(2007). // RX PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646; RA Quentmeier, Hilmar RA Pommerenke, Claudia RA Dirks, Wilhelm Gerhard RA Eberth, Sonja RA Koeppel, Max RA MacLeod, Roderick A.F. RA Nagel, Stefan RA Steube, Klaus G. RA Uphoff, Cord C. RA Drexler, Hans Gunther RT "The LL-100 panel: 100 cell lines for blood cancer studies."; RL Sci. 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RT Carboxylic esterase."; RL Leuk. Res. 9:209-229(1985). // RX PubMed=1373528; RA Duan, Da-Shuhn RA Smith, Wayne RA Sadee, Wolfgang RA Cowan, Morton J. RT "Characterization of three T-lymphoid cell lines with distinct RT sensitivities to deoxyadenosine plus deoxycoformycin."; RL Thymus 19:1-11(1992). // RX PubMed=15472075; DOI=10.1126/science.1102160; RA Weng, Andrew P. RA Ferrando, Adolfo A. RA Lee, Woojoong RA Morris, John P. 4th RA Silverman, Lewis B. RA Sanchez-Irizarry, Cheryll RA Blacklow, Stephen Charles RA Look, Alfred Thomas RA Aster, Jon Christopher RT "Activating mutations of NOTCH1 in human T cell acute lymphoblastic RT leukemia."; RL Science 306:269-271(2004). // RX PubMed=203546; DOI=10.1002/ijc.2910210207; RA Morikawa, Shigeru RA Tatsumi, Eiji RA Baba, Mitsuo RA Harada, Takayuki RA Yasuhira, Kimio RT "Two E-rosette-forming lymphoid cell lines."; RL Int. J. Cancer 21:166-170(1978). // RX PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588; RA Hosoya, Noriko RA Hangaishi, Akira RA Ogawa, Seishi RA Miyagawa, Kiyoshi RA Mitani, Kinuko RA Yazaki, Yoshio RA Hirai, Hisamaru RT "Frameshift mutations of the hMSH6 gene in human leukemia cell RT lines."; RL Jpn. J. Cancer Res. 89:33-39(1998). // RX PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x; RA Nakano, Akinobu RA Harada, Takayuki RA Morikawa, Shigeru RA Kato, Yuzuru RT "Expression of leukocyte common antigen (CD45) on various human RT leukemia/lymphoma cell lines."; RL Acta Pathol. Jpn. 40:107-115(1990). // RX PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786; RA Tan, Kar-Tong RA Ding, Ling-Wen RA Sun, Qiao-Yang RA Lao, Zhen-Tang RA Chien, Wenwen RA Ren, Xi RA Xiao, Jin-Fen RA Loh, Xin-Yi RA Xu, Liang RA Lill, Michael RA Mayakonda, Anand RA Lin, De-Chen RA Yang, Henry He RA Koeffler, Harold Phillip RT "Profiling the B/T cell receptor repertoire of lymphocyte derived cell RT lines."; RL BMC Cancer 18:940.1-940.13(2018). // RX PubMed=12661009; DOI=10.1002/gcc.10194; RA MacLeod, Roderick A.F. RA Nagel, Stefan RA Kaufmann, Maren RA Janssen, Johannes W.G. RA Drexler, Hans Gunther RT "Activation of HOX11L2 by juxtaposition with 3'-BCL11B in an acute RT lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2)."; RL Genes Chromosomes Cancer 37:84-91(2003). // RX PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886; RA Takizawa, Jun RA Suzuki, Ritsuro RA Kuroda, Hiroyuki RA Utsunomiya, Atae RA Kagami, Yoshitoyo RA Joh, Tatsuroh RA Aizawa, Yoshifusa RA Ueda, Ryuzo RA Seto, Masao RT "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not RT in adult T-cell leukemia."; RL Jpn. J. Cancer Res. 89:712-718(1998). // RX DOI=10.1016/B978-0-12-221970-2.50457-5; RA Drexler, Hans Gunther RT "The leukemia-lymphoma cell line factsbook."; RL (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144; RA Uphoff, Cord C. RA Pommerenke, Claudia RA Denkmann, Sabine A. RA Drexler, Hans Gunther RT "Screening human cell lines for viral infections applying RNA-Seq data RT analysis."; RL PLoS ONE 14:e0210404.1-e0210404.22(2019). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=6181032; DOI=10.1016/0198-8859(82)90037-4; RA Rabinowitz, Ruth RA Weinstock, J. RA Margalioth, Ehud J. RA Ben-Bassat, Hannah RA Schlesinger, Michael RT "Antigens specific for human T-lymphocytes detected by xenoantisera to RT HD-MAR cells: their differential expression on various T-cell lines."; RL Hum. Immunol. 4:219-228(1982). // RX PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900; RA Leo, Isabelle Rose RA Aswad, Luay RA Stahl, Matthias RA Kunold, Elena RA Post, Frederik RA Erkers, Tom RA Struyf, Nona RA Mermelekas, Georgios RA Joshi, Rubin Narayan RA Gracia-Villacampa, Eva RA Ostling, Paivi RA Kallioniemi, Olli-Pekka RA Pokrovskaja Tamm, Katja RA Siavelis, Ioannis RA Lehtio, Janne RA Vesterlund, Mattias RA Jafari, Rozbeh RT "Integrative multi-omics and drug response profiling of childhood RT acute lymphoblastic leukemia cell lines."; RL Nat. Commun. 13:1691.1-1691.19(2022). // RX PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4; RA Inoue, Kaoru RA Kohno, Takashi RA Takakura, Satoshi RA Hayashi, Yasuhide RA Mizoguchi, Hideaki RA Yokota, Jun RT "Frequent microsatellite instability and BAX mutations in T cell acute RT lymphoblastic leukemia cell lines."; RL Leuk. Res. 24:255-262(2000). // RX PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid RT phosphatase."; RL Leuk. Res. 9:537-548(1985). // RX PubMed=8127147; RA Heyman, Mats RA Grander, Dan RA Brondum-Nielsen, Karen RA Cederblad, Britta RA Liu, Yie RA Xu, Bo RA Einhorn, Stefan RT "Interferon system defects in malignant T-cells."; RL Leukemia 8:425-434(1994). //