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Cellosaurus K5 (CVCL_1322)

[Text version]
Cell line name K5
Accession CVCL_1322
Resource Identification Initiative To cite this cell line use: K5 (RRID:CVCL_1322)
Comments Problematic cell line: Contaminated. Shown to be a GLAG-66 derivative (STR profile and somatic mutations from Cosmic-CLP).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00590.
Population: Caucasian; Italian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (Cosmic-CLP=924238; DepMap=ACH-002148).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (Cosmic-CLP=924238; DepMap=ACH-002148).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.75
Native American0
East Asian, North0
East Asian, South1.37
South Asian7.25
European, North35.45
European, South54.17
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9918 (GLAG-66)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=924238

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81810,11
D7S82011
D13S31711,14
D16S53911,12
TH016,9
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=10646882; DOI=10.1054/bjoc.1999.0920; PMCID=PMC2363282
Bounacer A., Schlumberger M., Wicker R., du Villard J.-A., Caillou B., Sarasin A., Suarez H.G.
Search for NTRK1 proto-oncogene rearrangements in human thyroid tumours originated after therapeutic radiation.
Br. J. Cancer 82:308-314(2000)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources CLO; CLO_0037154
cancercelllines; CVCL_1322
Cell_Model_Passport; SIDM00056
Cosmic-CLP; 924238
DepMap; ACH-002148
LINCS_LDP; LCL-1692
Chemistry resources ChEMBL-Cells; CHEMBL3308144
ChEMBL-Targets; CHEMBL2366152
GDSC; 924238
PharmacoDB; K5_724_2019
PubChem_Cell_line; CVCL_1322
Encyclopedic resources Wikidata; Q54899290
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669970
Polymorphism and mutation databases Cosmic; 924238
Cosmic; 928832
Cosmic; 1162843
Cosmic; 1507370
Cosmic; 1533547
Cosmic; 1536123
Cosmic; 1789444
Cosmic; 1889002
Cosmic; 2791090
IARC_TP53; 27559
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number36