ID K5 AC CVCL_1322 DR CLO; CLO_0037154 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-3610 DR cancercelllines; CVCL_1322 DR Cell_Model_Passport; SIDM00056 DR ChEMBL-Cells; CHEMBL3308144 DR ChEMBL-Targets; CHEMBL2366152 DR Cosmic; 924238 DR Cosmic; 928832 DR Cosmic; 1162843 DR Cosmic; 1507370 DR Cosmic; 1533547 DR Cosmic; 1536123 DR Cosmic; 1789444 DR Cosmic; 1889002 DR Cosmic; 2791090 DR Cosmic-CLP; 924238 DR DepMap; ACH-002148 DR EGA; EGAS00001000978 DR GDSC; 924238 DR GEO; GSM1669970 DR IARC_TP53; 27559 DR LINCS_LDP; LCL-1692 DR PharmacoDB; K5_724_2019 DR PRIDE; PXD030304 DR PubChem_Cell_line; CVCL_1322 DR Wikidata; Q54899290 RX PubMed=10646882; RX PubMed=20164919; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=35839778; WW Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx CC Problematic cell line: Contaminated. Shown to be a GLAG-66 derivative (STR profile and somatic mutations from Cosmic-CLP). CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00590. CC Population: Caucasian; Italian. CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (Cosmic-CLP=924238; DepMap=ACH-002148). CC Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (Cosmic-CLP=924238; DepMap=ACH-002148). CC Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=1.75%; Native American=0%; East Asian, North=0%; East Asian, South=1.37%; South Asian=7.25%; European, North=35.45%; European, South=54.17% (PubMed=30894373). CC Derived from site: Metastatic; Thyroid gland; UBERON=UBERON_0002046. ST Source(s): Cosmic-CLP=924238 ST Amelogenin: X,Y ST CSF1PO: 11,12 ST D13S317: 11,14 ST D16S539: 11,12 ST D5S818: 10,11 ST D7S820: 11 ST TH01: 6,9 ST TPOX: 8 ST vWA: 17,18 DI NCIt; C4035; Thyroid gland papillary carcinoma DI ORDO; Orphanet_146; Differentiated thyroid carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_9918 ! GLAG-66 SX Male AG 58Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 38 // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=10646882; DOI=10.1054/bjoc.1999.0920; PMCID=PMC2363282; RA Bounacer, Ali RA Schlumberger, Martin RA Wicker, Rene RA du Villard, Jean-Antoine RA Caillou, Bernard RA Sarasin, Alain RA Suarez, Horacio Guillermo RT "Search for NTRK1 proto-oncogene rearrangements in human thyroid RT tumours originated after therapeutic radiation."; RL Br. J. Cancer 82:308-314(2000). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). //