Cellosaurus logo
expasy logo

Cellosaurus IMR-5 (CVCL_1306)

[Text version]
Cell line name IMR-5
Synonyms IMR 5; IMR5; IMR-05; Institute for Medical Research-5
Accession CVCL_1306
Resource Identification Initiative To cite this cell line use: IMR-5 (RRID:CVCL_1306)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Abdomen; UBERON=UBERON_0000916.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.86
East Asian, North0
East Asian, South0.06
South Asian4.46
European, North75.37
European, South19.24
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0346 (IMR-32)
Children:
CVCL_M473 (IMR-5/75)CVCL_M472 (IMR-5/M-1)CVCL_RT17 (IMR-5rCARBO5000)
CVCL_RR56 (IMR-5rCDDP1000)CVCL_RS59 (IMR-5rDACARB20)CVCL_ZX19 (IMR-5rDACARB40)
CVCL_RR57 (IMR-5rDOCE20)CVCL_RR58 (IMR-5rDOX20)CVCL_RR59 (IMR-5rETO100)
CVCL_RR60 (IMR-5rGEMCI20)CVCL_RS63 (IMR-5rIRINO1000)CVCL_RS62 (IMR-5rMEL1000)
CVCL_RR61 (IMR-5rMEL3000)CVCL_RR62 (IMR-5rOXALI4000)CVCL_RR63 (IMR-5rPCL20)
CVCL_RR64 (IMR-5rTOPO20)CVCL_RR37 (IMR-5rVCR10)CVCL_RS64 (IMR-5rVINB20)
CVCL_RR65 (IMR-5rVINOR20)
Sex of cell Male
Age at sampling 1Y1M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=907170; PubMed=31581737

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133823,24
D3S135816
D5S81811,12
D7S8209,10
D8S117913
D13S3179
D16S5398
D18S5112,15
D19S43314,15
D21S1130,31
FGA21,24
Penta D11,12
Penta E7,15
TH017,9.3
TPOX11
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=6160155; DOI=10.1016/S0021-9258(19)70222-1
Mariko Momoi, Roger H. Kennett, Mary Catherine Glick;
A membrane glycoprotein from human neuroblastoma cells isolated with the use of a monoclonal antibody.
J. Biol. Chem. 255:11914-11921(1980)

PubMed=12536080; DOI=10.1016/S0304-3835(02)00581-5
Matthias Fischer, Frank Berthold;
Characterization of the gene expression profile of neuroblastoma cell line IMR-5 using serial analysis of gene expression.
Cancer Lett. 190:79-87(2003)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Karl-Ludwig Schaefer, Kristin Brachwitz, Daniel H. Wai, Yvonne Braun, Raihanatou Diallo, Eberhard Korsching, Martin Eisenacher, Reinhard Voss, Frans van Valen, Claudia Baer, Barbara Selle, Laura Spahn, Shuen-Kuei Liao ...Show all 18 authors... , Kevin A.W. Lee, Pancras Cornelis Wilhelmus Hogendoorn, Guido Reifenberger, Helmut Erich Gabbert, Christopher Poremba; Show fewer authors
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys, Frank Speleman, Cecilia Kim ...Show all 22 authors... , Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathan Hinton, Ciara Fahey ...Show all 22 authors... , Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Mark Sausen, Rebecca J. Leary, Sian Jones, Jian Wu, Charles Patrick Reynolds, Xue-Yuan Liu, Amanda L. Blackford, Giovanni Parmigiani, Luis Alberto Diaz Jr., Nickolas Papadopoulos, Bert Vogelstein, Kenneth Wayne Kinzler, Victor E. Velculescu ...Show all 14 authors... , Michael D. Hogarty; Show fewer authors
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner, Taravat Ghafourian, Frank Westermann ...Show all 14 authors... , Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31581737; DOI=10.3390/cells8101194; PMCID=PMC6830094
Jane F. Povey, Emily Saintas, Adewale Victor Aderemi, Florian Rothweiler, Richard Zehner, Wilhelm Gerhard Dirks, Jindrich Cinatl Jr., Andrew J. Racher, Mark N. Wass, Christopher Mark Smales, Martin Michaelis;
Intact-cell MALDI-ToF mass spectrometry for the authentication of drug-adapted cancer cell lines.
Cells 8:1194.1-1194.12(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ICLC; HTL00009
Cell line databases/resources CLO; CLO_0006950
CLDB; cl5097
cancercelllines; CVCL_1306
Cell_Model_Passport; SIDM01206
Cosmic-CLP; 907170
DepMap; ACH-002248
LINCS_LDP; LCL-1984
Anatomy/cell type resources BTO; BTO_0005846
Chemistry resources ChEMBL-Cells; CHEMBL3308201
ChEMBL-Targets; CHEMBL2366209
GDSC; 907170
PharmacoDB; IMR5_660_2019
PubChem_Cell_line; CVCL_1306
Encyclopedic resources Wikidata; Q54897648
Experimental variables resources EFO; EFO_0022692
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669935
GEO; GSM2371236
GEO; GSM2394389
Polymorphism and mutation databases Cosmic; 907170
Cosmic; 1019939
Cosmic; 1109364
Cosmic; 1161989
Cosmic; 1167417
Cosmic; 1890113
IARC_TP53; 21396
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37