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Cellosaurus IGROV-1 (CVCL_1304)

[Text version]
Cell line name IGROV-1
Synonyms Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P
Accession CVCL_1304
Resource Identification Initiative To cite this cell line use: IGROV-1 (RRID:CVCL_1304)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
Part of: OCCP ovarian cancer cell line panel.
Population: Caucasian.
Doubling time: 30 hours (PubMed=25984343); ~23 hours (PubMed=10817511); 28 +- 1 hours (PubMed=9636834); 28 hours (PubMed=9488600); 31 hours (NCI-DTP=IGR-OV1); 19.53 hours (JWGray panel).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; Fluorescent probe library screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Misspelling: IGROV-4; PubMed=12960427.
Misspelling: IGR-OV1-RU; Cosmic=1175880.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Lys654Serfs*47 (c.1961delA); ClinVar=VCV000037438; Zygosity=Heterozygous (PubMed=17088437; PubMed=25230021; Cosmic-CLP=905968).
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Lys1108Argfs*11 (c.3323delA) (p.Gln1107fs) (c.3320delA); ClinVar=VCV000225716; Zygosity=Unspecified (PubMed=25230021).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Arg38Cys (c.112C>T); ClinVar=VCV000376493; Zygosity=Heterozygous (Cosmic-CLP=905968; DepMap=ACH-000966).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Ter1069TrpinsLysAspAsn (c.3207A>G); Zygosity=Heterozygous (Cosmic-CLP=905968; DepMap=ACH-000966).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (PubMed=17088437; PubMed=25230021; Cosmic-CLP=905968; DepMap=ACH-000966).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); ClinVar=VCV002724056; Zygosity=Heterozygous (Cosmic-CLP=905968; DepMap=ACH-000966).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gly231Alafs*10 (c.692delG); ClinVar=VCV001756201; Zygosity=Heterozygous (PubMed=17088437; Cosmic-CLP=905968; DepMap=ACH-000966).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Leu495Pro (c.1484T>C); Zygosity=Heterozygous (PubMed=17088437; Cosmic-CLP=905968; DepMap=ACH-000966).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Leufs*59 (c.267dupC) (c.267_268insC); ClinVar=VCV000634762; Zygosity=Heterozygous (PubMed=17088437; PubMed=24023729; PubMed=25230021; Cosmic-CLP=905968; DepMap=ACH-000966).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Cys (c.377A>G); ClinVar=VCV000458541; Zygosity=Heterozygous (PubMed=17088437; PubMed=24023729; PubMed=25230021; Cosmic-CLP=905968; DepMap=ACH-000966).
HLA typing Source: PubMed=15748285
Class I
HLA-AA*24:02:01,33:01
HLA-BB*49:01
HLA-CC*07
Class II
HLA-DPDPB1*05:01
HLA-DQDQB1*03
HLA-DRDRB1*11,11

Source: PubMed=26589293
Class I
HLA-AA*24:02,33:03
HLA-BB*45:01,49:01
HLA-CC*07:01,07:01
Class II
HLA-DQDQA1*01:02,01:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.69
Native American0
East Asian, North0
East Asian, South1.43
South Asian4.55
European, North46.04
European, South47.29
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C1M7 (IGROV(CDDP))CVCL_4V48 (IGROV(T100r))CVCL_8723 (IGROV-1/25 ET)
CVCL_4Y61 (IGROV-1/APL)CVCL_IQ21 (IGROV-1/CP)CVCL_EQ59 (IGROV-1/MX3)
CVCL_EQ61 (IGROV-1/Pt0.5)CVCL_EQ62 (IGROV-1/Pt1)CVCL_EQ60 (IGROV-1/T8)
CVCL_8744 (OV1/ADR)CVCL_8745 (OV1/CDDP)CVCL_8746 (OV1/VCR)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=905968; Millipore=SCC203; PubMed=19372543; PubMed=25230021; PubMed=25877200; PubMed=30485824

Markers:
AmelogeninX
CSF1PO11,12,13,14,15,16 (Millipore=SCC203)
11,13 (PubMed=19372543; PubMed=30485824)
11,13,14,15 (Cosmic-CLP=905968)
11,13,15 (PubMed=25877200)
11,16 (PubMed=25230021)
D2S133817,25
D3S135813,14,15 (Millipore=SCC203; PubMed=25230021; PubMed=25877200)
13,15 (PubMed=19372543)
D5S81811,12,13 (Millipore=SCC203)
12 (PubMed=25877200; PubMed=30485824)
12,13 (Cosmic-CLP=905968; PubMed=19372543; PubMed=25230021)
D7S8209.1,10.1,11.1 (PubMed=25230021)
9.3,10.1 (PubMed=30485824)
10 (PubMed=25877200)
10,10.1,10.3,11.1 (Millipore=SCC203)
11 (Cosmic-CLP=905968)
D8S117913,14,15,16,17 (Millipore=SCC203)
14,16 (PubMed=25230021; PubMed=25877200)
D13S3178,10
D16S53910,11,12,13 (Millipore=SCC203)
11,12 (Cosmic-CLP=905968; PubMed=19372543; PubMed=25877200)
11,13 (PubMed=30485824)
12 (PubMed=25230021)
D18S5114,15,16 (Millipore=SCC203)
14,16,17 (PubMed=25230021)
15,16 (PubMed=25877200)
D19S43313,14
D21S1126,29.2,30.2 (PubMed=25230021)
26,30.2 (PubMed=25877200; PubMed=30485824)
26,30.2,31.2 (Millipore=SCC203)
FGA20,21,26 (PubMed=25230021)
21,25,26 (Millipore=SCC203)
21,26 (PubMed=25877200)
Penta D8,10
Penta E13,17
TH017,9.3
TPOX8,11 (Millipore=SCC203; PubMed=19372543; PubMed=25230021; PubMed=25877200; PubMed=30485824)
8,11,12 (Cosmic-CLP=905968)
vWA16,17,20,21,22 (Millipore=SCC203)
16,17,20,22 (PubMed=25230021)
17,21 (Cosmic-CLP=905968; PubMed=19372543; PubMed=30485824)
17,21,22 (PubMed=25877200)

Run an STR similarity search on this cell line
Web pages Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=26
Publications

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=2041050; DOI=10.1093/jnci/83.11.757
Anne Monks, Dominic A. Scudiero, Philip Skehan, Robert H. Shoemaker, Kenneth D. Paull, David T. Vistica, Curtis D. Hose, John Langley, Paul Cronise, Anne Vaigro-Wolff, Marcia Gray-Goodrich ...Show all 14 authors... , Hugh Campbell, Joseph G. Mayo, Michael R. Boyd; Show fewer authors
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991)

PubMed=8564971
Paola Perego, Monica Giarola, Sabina C. Righetti, Rosanna Supino, Claudia Caserini, Domenico Delia, Marco Alessandro Pierotti, Toshiyuki Miyashita, John C. Reed, Franco Zunino;
Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.
Cancer Res. 56:556-562(1996)

PubMed=9331090
Patrick M. O'Connor, Joany Jackman, Insoo Bae, Timothy Gene Myers, Sai-Jun Fan, Masato Mutoh, Dominic A. Scudiero, Anne Monks, Edward A. Sausville, John N. Weinstein, Stephen H. Friend ...Show all 13 authors... , Albert J. Fornace Jr., Kurt W. Kohn; Show fewer authors
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
Cancer Res. 57:4285-4300(1997)

PubMed=9443634; DOI=10.1007/s002800050727
Jian-Guo Ma, Marc Maliepaard, Herman J. Kolker, Jaap Verweij, Jan H.M. Schellens;
Abrogated energy-dependent uptake of cisplatin in a cisplatin-resistant subline of the human ovarian cancer cell line IGROV-1.
Cancer Chemother. Pharmacol. 41:186-192(1998)

PubMed=9488600; DOI=10.1007/s002800050744
Jian-Guo Ma, Marc Maliepaard, Kees Nooter, Antonius W.M. Boersma, Jaap Verweij, Gerrit Stoter, Jan H.M. Schellens;
Synergistic cytotoxicity of cisplatin and topotecan or SN-38 in a panel of eight solid-tumor cell lines in vitro.
Cancer Chemother. Pharmacol. 41:307-316(1998)

PubMed=9636834; DOI=10.1023/A:1008265012435
Paola Perego, Simona Romanelli, Nives Carenini, Ivana Magnani, Roberto Leone, Andrea Bonetti, Aldo Paolicchi, Franco Zunino;
Ovarian cancer cisplatin-resistant cell lines: multiple changes including collateral sensitivity to taxol.
Ann. Oncol. 9:423-430(1998)

PubMed=10700174; DOI=10.1038/73432
Douglas T. Ross, Uwe Scherf, Michael Bruce Eisen, Charles M. Perou, Christian Rees, Paul T. Spellman, Vishwanath R. Iyer, Stefanie S. Jeffrey, Matt van de Rijn, Mark C. Waltham, Alexander Pergamenschikov ...Show all 18 authors... , Jeffrey C.F. Lee, Deval Lashkari, Dari Shalon, Timothy Gene Myers, John N. Weinstein, David Botstein, Patrick O'Reilly Brown; Show fewer authors
Systematic variation in gene expression patterns in human cancer cell lines.
Nat. Genet. 24:227-235(2000)

PubMed=10817511; DOI=10.1054/bjoc.2000.1224; PMCID=PMC2374505
Eugenio Erba, Daniele Bergamaschi, L. Bassano, Simona Ronzoni, G. Di Liberti, Ivan Muradore, Sara Vignati, Glynn T. Faircloth, Jose Maria Jimeno, Maurizio D'Incalci;
Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743).
Br. J. Cancer 82:1732-1739(2000)

PubMed=12960427; DOI=10.1091/mbc.E03-05-0279; PMCID=PMC266758
Marci E. Schaner, Douglas T. Ross, Giuseppe Ciaravino, Therese Sorlie, Olga G. Troyanskaya, Maximilian Diehn, Yan C. Wang, George E. Duran, Thomas L. Sikic, Sandra Caldeira, Hanne Skomedal ...Show all 26 authors... , I-Ping Tu, Tina Hernandez-Boussard, Steven W. Johnson, Peter J. O'Dwyer, Michael J. Fero, Gunnar B. Kristensen, Anne-Lise Borresen-Dale, Trevor John Hastie, Robert Tibshirani, Matt van de Rijn, Nelson N.H. Teng, Teri A. Longacre, David Botstein, Patrick O'Reilly Brown, Branimir I. Sikic; Show fewer authors
Gene expression patterns in ovarian carcinomas.
Mol. Biol. Cell 14:4376-4386(2003)

PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742
Sharon Adams, Fu-Meei Robbins, Deborah Chen, Devika Wagage, Susan L. Holbeck, Herbert Carpenter Morse 3rd, David Stroncek, Francesco M. Marincola;
HLA class I and II genotype of the NCI-60 cell lines.
J. Transl. Med. 3:11.1-11.8(2005)

PubMed=16319398; DOI=10.1074/mcp.M500140-MCP200
Jennifer J. Stewart, James T. White, Xiao-Wei Yan, Steven J. Collins, Charles W. Drescher, Nicole D. Urban, Leroy Edward Hood, Biao-Yang Lin;
Proteins associated with cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels.
Mol. Cell. Proteomics 5:433-443(2006)

PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832
Ogechi N. Ikediobi, Helen R. Davies, Graham Robert Bignell, Sarah Edkins, Claire Stevens, Sarah O'Meara, Thomas Santarius, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck ...Show all 49 authors... , Adam P. Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathan Hinton, Chris Hunter, Andy Jenkinson, David Jones, Vivian Kosmidou, Richard Lugg, Andrew Menzies, Tatiana Mironenko, Adrian Parker, Janet Perry, Keiran Martin Raine, David Richardson, Rebecca Shepherd, Alex Small, Raffaella Smith, Helen Solomon, Philip J. Stephens, Jon W. Teague, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, William C. Reinhold, John N. Weinstein, Michael Rudolf Stratton, P. Andrew Futreal, Richard Wooster; Show fewer authors
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)

PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356
Philip L. Lorenzi, William C. Reinhold, Sudhir Varma, Amy A. Hutchinson, Yves Pommier, Stephen Jacob Chanock, John N. Weinstein;
DNA fingerprinting of the NCI-60 cell line panel.
Mol. Cancer Ther. 8:713-724(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108
Jean-Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Miguel Marino, Lisa J. Green, Meena I. Vora, Chirayu Patel, Josiah N. Orina, Tatiana A. Eliseeva, Vineet Singal, Raji Padmanabhan ...Show all 17 authors... , Ben Davidson, Ram Ganapathi, Anil K. Sood, Bo R. Rueda, Suresh V. Ambudkar, Michael Marc Gottesman; Show fewer authors
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.
Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011)

PubMed=22328975; DOI=10.1158/2159-8290.CD-11-0170; PMCID=PMC3274821
Aphrothiti J. Hanrahan, Nikolaus Schultz, Maggie L. Westfal, Rita A. Sakr, Dilip D. Giri, Stefano Scarperi, Manickam Janakiraman, Narciso Olvera, Ellen V. Stevens, Qing-Bai She, Carol Aghajanian ...Show all 20 authors... , Tari A. King, Elisa de Stanchina, David R. Spriggs, Adriana Heguy, Barry Stephen Taylor, Chris Sander, Neal Rosen, Douglas A. Levine, David B. Solit; Show fewer authors
Genomic complexity and AKT dependence in serous ovarian cancer.
Cancer Discov. 2:56-67(2012)

PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511
Xiao-Yang Ruan, Jean-Pierre A. Kocher, Yves Pommier, Hong-Fang Liu, William C. Reinhold;
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap trios, and relation to fragile site location.
PLoS ONE 7:e31628.1-e31628.9(2012)

PubMed=22384151; DOI=10.1371/journal.pone.0032096; PMCID=PMC3285665
Jun-Seok Lee, Yun Kyung Kim, Han Jo Kim, Siti Hajar, Yee Ling Tan, Nam-Young Kang, Shin Hui Ng, Chang No Yoon, Young-Tae Chang;
Identification of cancer cell-line origins using fluorescence image-based phenomic screening.
PLoS ONE 7:e32096.1-e32096.8(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22628656; DOI=10.1126/science.1218595; PMCID=PMC3526189
Mohit Jain, Roland Nilsson, Sonia Sharma, Nikhil Madhusudhan, Toshimori Kitami, Amanda L. Souza, Ran Kafri, Marc Wallace Kirschner, Clary B. Clish, Vamsi Krishna Mootha;
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Science 336:1040-1044(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Britta Stordal, Kirsten Timms, Angela Farrelly, Danielle Gallagher, Steven Busschots, Mickael Renaud, Julien Thery, Deborah Williams, Jennifer Potter, Thanh Tran, Greg Korpanty ...Show all 19 authors... , Mattia Cremona, Mark S. Carey, Jie Li, Yang Li, Ozlem Aslan, John J. O'Leary, Gordon B. Mills, Bryan T. Hennessy; Show fewer authors
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866
Silvia Domcke, Rileen Sinha, Douglas A. Levine, Chris Sander, Nikolaus Schultz;
Evaluating cell lines as tumour models by comparison of genomic profiles.
Nat. Commun. 4:2126.1-2126.10(2013)

PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342; PMCID=PMC4893961
Ogan Demir Abaan, Eric C. Polley, Sean R. Davis, Yue-Lin J. Zhu, Sven Bilke, Robert L. Walker, Marbin A. Pineda, Yevgeniy Gindin, Yuan Jiang, William C. Reinhold, Susan L. Holbeck ...Show all 15 authors... , Richard M. Simon, James H. Doroshow, Yves Pommier, Paul S. Meltzer; Show fewer authors
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.
Cancer Res. 73:4372-4382(2013)

PubMed=23913215; DOI=10.1007/978-1-62703-547-7_12
Li-Sha Li, Jie Liu, Wei Yu, Xiao-Yan Lou, Bing-Ding Huang, Biao-Yang Lin;
Deep transcriptome profiling of ovarian cancer cells using next-generation sequencing approach.
Methods Mol. Biol. 1049:139-169(2013)

PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018
Amin Moghaddas Gholami, Hannes Hahne, Zhi-Xiang Wu, Florian Johann Auer, Chen Meng, Mathias Wilhelm, Bernhard Kuster;
Global proteome analysis of the NCI-60 cell line panel.
Cell Rep. 4:609-620(2013)

PubMed=24023729; DOI=10.1371/journal.pone.0072162; PMCID=PMC3762837
Michael S. Anglesio, Kimberly C. Wiegand, Nataliya Melnyk, Christine Chow, Clara M. Salamanca, Leah M. Prentice, Janine Senz, Winnie Yang, Monique A. Spillman, Dawn R. Cochrane, Karey Shumansky ...Show all 14 authors... , Sohrab P. Shah, Steve E. Kalloger, David G. Huntsman; Show fewer authors
Type-specific cell line models for type-specific ovarian cancer research.
PLoS ONE 8:e72162.1-e72162.13(2013)

PubMed=24279929; DOI=10.1186/2049-3002-1-20; PMCID=PMC4178206
Sonia C. Dolfi, Leo Li-Ying Chan, Jean Qiu, Philip M. Tedeschi, Joseph Rocco Bertino, Kim Marie Hirshfield, Zoltan Nagy Oltvai, Alexei Vazquez;
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates.
Cancer Metab. 1:20.1-20.13(2013)

PubMed=24670534; DOI=10.1371/journal.pone.0092047; PMCID=PMC3966786
Sudhir Varma, Yves Pommier, Margot Sunshine, John N. Weinstein, William C. Reinhold;
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:e92047.1-e92047.15(2014)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Corine M. Beaufort, Jean C.A. Helmijr, Anna M. Piskorz, Marlous Hoogstraat, Kirsten Ruigrok-Ritstier, Nicolle Besselink, Muhammed Murtaza, Wilfred F.J. van IJcken, Anouk A.J. Heine, Marcel Smid, Marco J. Koudijs ...Show all 14 authors... , James D. Brenton, Els M.J.J. Berns, Jozien Helleman; Show fewer authors
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:e103988.1-e103988.16(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27235858; DOI=10.1016/j.ygyno.2016.05.028; PMCID=PMC4961516
Lidia Hernandez, Marianne K. Kim, L. Tiffany Lyle, Kristen P. Bunch, Carrie D. House, Franklin Ning, Anne M. Noonan, Christina Messineo Annunziata;
Characterization of ovarian cancer cell lines as in vivo models for preclinical studies.
Gynecol. Oncol. 142:332-340(2016)

PubMed=27377824; DOI=10.1038/sdata.2016.52; PMCID=PMC4932877
Pieter Mestdagh, Steve Lefever, Pieter-Jan Volders, Stefaan Derveaux, Jan Hellemans, Jo Vandesompele;
Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR.
Sci. Data 3:160052.1-160052.6(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27561551; DOI=10.1038/ncomms12645; PMCID=PMC5007461
Fabian Coscia, Karen M. Watters, Marion Curtis, Mark A. Eckert, Chun-Yi Chiang, Stefka Tyanova, Anthony Montag, Ricardo R. Lastra, Ernst Robert Lengyel, Matthias Mann;
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Nat. Commun. 7:12645.1-12645.14(2016)

PubMed=27807467; DOI=10.1186/s13100-016-0078-4; PMCID=PMC5087121
John G. Zampella, Nemanja Rodic, Wan Rou Yang, Cheng Ran Lisa Huang, Jane Welch, Veena P. Gnanakkan, Toby Charles Cornish, Jef D. Boeke, Kathleen H. Burns;
A map of mobile DNA insertions in the NCI-60 human cancer cell panel.
Mob. DNA 7:20.1-20.11(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945
Eniko Papp, Dorothy Hallberg, Gottfried E. Konecny, Daniel C. Bruhm, Vilmos Adleff, Michael Noe, Ioannis Kagiampakis, Doreen Palsgrove, Dylan Conklin, Yasuto Kinose, James R. White ...Show all 18 authors... , Michael F. Press, Ronny I. Drapkin, Hariharan Easwaran, Stephen Bruce Baylin, Dennis Joseph Slamon, Victor E. Velculescu, Robert B. Scharpf; Show fewer authors
Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
Cell Rep. 25:2617-2633(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=32612269; DOI=10.1038/s41598-020-67533-1; PMCID=PMC7329846
Alexis Katherine De Haven Brandon, Gary Box, Albert Hallsworth, William Court, Nicoll Matthews, Balint Herodek, Aitor Bermejo Arteagabeitia, Melanie Valenti, Vladimir Kirkin;
Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice.
Sci. Rep. 10:10799.1-10799.13(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=38861359; DOI=10.1158/0008-5472.CAN-23-3031; PMCID=PMC11292194
Mark W. Kunkel, Nathan P. Coussens, Joel Morris, Ronald C. Taylor, Thomas S. Dexheimer, Eric M. Jones, James H. Doroshow, Beverly A. Teicher;
HTS384 NCI60: the next phase of the NCI60 screen.
Cancer Res. 84:2403-2416(2024)

Cross-references
Cell line collections (Providers) Millipore; SCC203
NCI-DTP; IGR-OV1
Cell line databases/resources CLO; CLO_0006672
CLDB; cl2627
cancercelllines; CVCL_1304
Cell_Model_Passport; SIDM00151
Cosmic-CLP; 905968
DepMap; ACH-000966
Lonza; 175
SKY/M-FISH/CGH; 2739
Anatomy/cell type resources BTO; BTO_0002575
Biological sample resources BioSample; SAMN03470926
BioSample; SAMN10988218
CRISP screens repositories BioGRID_ORCS_Cell_line; 897
Chemistry resources ChEMBL-Cells; CHEMBL3307502
ChEMBL-Targets; CHEMBL613984
GDSC; 905968
PharmacoDB; IGROV1_654_2019
PubChem_Cell_line; CVCL_1304
Encyclopedic resources Wikidata; Q54897382
Experimental variables resources EFO; EFO_0005385
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSE23440
GEO; GSE25191
GEO; GSM2127
GEO; GSM50218
GEO; GSM50281
GEO; GSM313715
GEO; GSM711720
GEO; GSM743472
GEO; GSM743496
GEO; GSM750827
GEO; GSM799361
GEO; GSM799424
GEO; GSM844567
GEO; GSM844568
GEO; GSM844569
GEO; GSM844570
GEO; GSM846360
GEO; GSM851919
GEO; GSM887160
GEO; GSM888232
GEO; GSM1153432
GEO; GSM1181284
GEO; GSM1181285
GEO; GSM1291142
GEO; GSM1374571
GEO; GSM1669930
GEO; GSM2124667
Polymorphism and mutation databases Cosmic; 688100
Cosmic; 875857
Cosmic; 897430
Cosmic; 905968
Cosmic; 920360
Cosmic; 947357
Cosmic; 1044236
Cosmic; 1092607
Cosmic; 1093557
Cosmic; 1102823
Cosmic; 1175880
Cosmic; 1305334
Cosmic; 1312353
Cosmic; 1707557
Cosmic; 1709252
Cosmic; 1998449
Cosmic; 2464669
IARC_TP53; 21072
IARC_TP53; 21125
IARC_TP53; 30209
LiGeA; CCLE_165
Progenetix; CVCL_1304
Proteomic databases PRIDE; PXD003668
PRIDE; PXD005942
PRIDE; PXD005946
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number47