| Cell line name |
IGROV-1/Pt0.5 |
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| Synonyms |
IGROV-1/Pt 0.5; IGROV1/Pt0.5 |
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| Accession |
CVCL_EQ61 |
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| Resource Identification Initiative |
To cite this cell line use: IGROV-1/Pt0.5 (RRID:CVCL_EQ61) |
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| Comments |
Population: Caucasian.
Doubling time: 36 +- 2.2 hours (PubMed=9636834).
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Lys654Serfs*47 (c.1961delA); ClinVar=VCV000037438; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Lys1108Argfs*11 (c.3323delA) (p.Gln1107fs) (c.3320delA); ClinVar=VCV000225716; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Arg38Cys (c.112C>T); ClinVar=VCV000376493; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Ter1069TrpinsLysAspAsn (c.3207A>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); ClinVar=VCV002724056; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gly231Alafs*10 (c.692delG); ClinVar=VCV001756201; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Leu495Pro (c.1484T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Leufs*59 (c.267dupC) (c.267_268insC); ClinVar=VCV000634762; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Cys (c.377A>G); ClinVar=VCV000458541; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Phe270Leu (c.808T>C); ClinVar=VCV000634778; Zygosity=Heterozygous (PubMed=8564971).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Heterozygous (PubMed=8564971).
|
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| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1304 (IGROV-1) |
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| Sex of cell |
Female |
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| Age at sampling |
47Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8564971
Paola Perego, Monica Giarola, Sabina C. Righetti, Rosanna Supino, Claudia Caserini, Domenico Delia, Marco Alessandro Pierotti, Toshiyuki Miyashita, John C. Reed, Franco Zunino;
Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.
Cancer Res. 56:556-562(1996) PubMed=9636834; DOI=10.1023/A:1008265012435
Paola Perego, Simona Romanelli, Nives Carenini, Ivana Magnani, Roberto Leone, Andrea Bonetti, Aldo Paolicchi, Franco Zunino;
Ovarian cancer cisplatin-resistant cell lines: multiple changes including collateral sensitivity to taxol.
Ann. Oncol. 9:423-430(1998) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_EQ61
|
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| Encyclopedic resources |
Wikidata; Q54897387
|
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| Polymorphism and mutation databases |
IARC_TP53; 5443
|
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| Entry history |
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| Entry creation | 26-Sep-2016 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 17 |
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