Cell line name |
IGROV-1/CP |
Synonyms |
IGROV-1-CP; IGROV1CP |
Accession |
CVCL_IQ21 |
Resource Identification Initiative |
To cite this cell line use: IGROV-1/CP (RRID:CVCL_IQ21) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP). Omics: Deep proteome analysis. Omics: Transcriptome analysis by RNAseq. Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
Sequence variations |
- Mutation; HGNC; 1100; BRCA1; Simple; p.Lys654Serfs*47 (c.1961delA); ClinVar=VCV000037438; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1101; BRCA2; Simple; p.Lys1108Argfs*11 (c.3323delA) (p.Gln1107fs) (c.3320delA); ClinVar=VCV000225716; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Arg38Cys (c.112C>T); ClinVar=VCV000376493; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Ter1069TrpinsLysAspAsn (c.3207A>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gly231Alafs*10 (c.692delG); ClinVar=VCV001756201; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Leu495Pro (c.1484T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Ser90Leufs*59 (c.267dupC) (c.267_268insC); ClinVar=VCV000634762; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Cys (c.377A>G); ClinVar=VCV000458541; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979) Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_1304 (IGROV-1) |
Sex of cell |
Female |
Age at sampling |
47Y |
Category |
Cancer cell line |
Publications | PubMed=16319398; DOI=10.1074/mcp.M500140-MCP200 Stewart J.J., White J.T., Yan X.-W., Collins S.J., Drescher C.W., Urban N.D., Hood L.E., Lin B.-Y. Proteins associated with cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels. Mol. Cell. Proteomics 5:433-443(2006) PubMed=23913215; DOI=10.1007/978-1-62703-547-7_12 Li L.-S., Liu J., Yu W., Lou X.-Y., Huang B.-D., Lin B.-Y. Deep transcriptome profiling of ovarian cancer cells using next-generation sequencing approach. Methods Mol. Biol. 1049:139-169(2013) PubMed=27561551; DOI=10.1038/ncomms12645; PMCID=PMC5007461 Coscia F., Watters K.M., Curtis M., Eckert M.A., Chiang C.-Y., Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M. Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status. Nat. Commun. 7:12645.1-12645.14(2016) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_IQ21
|
Encyclopedic resources |
Wikidata; Q54897385
|
Proteomic databases |
PRIDE; PXD003668
|
Entry history |
Entry creation | 03-Mar-2017 |
Last entry update | 05-Oct-2023 |
Version number | 17 |
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