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Cellosaurus IGR-1 (CVCL_1303)

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Cell line name IGR-1
Synonyms IGR 1; IGR1; Institut Gustave Roussy-1
Accession CVCL_1303
Resource Identification Initiative To cite this cell line use: IGR-1 (RRID:CVCL_1303)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: ~75-100 hours (DSMZ=ACC-236).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Inguinal lymph node; UBERON=UBERON_0001542.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Lys (c.1798_1799delGTinsAA); ClinVar=VCV000375941; Zygosity=Heterozygous (PubMed=25056119; Cosmic-CLP=907169; DepMap=ACH-000882).
  • Mutation; HGNC; HGNC:9801; RAC1; Simple; p.Pro29Ser (c.85C>T); ClinVar=VCV000376362; Zygosity=Heterozygous (PubMed=25056119; Cosmic-CLP=907169; DepMap=ACH-000882).
HLA typing Source: CLS=300219
Class I
HLA-AA*02:01:01,03:01:01
HLA-BB*11:01:01,44:02:01
HLA-CC*04:01:01,05:01:01
Class II
HLA-DPDPB1*04:01:01G,04:02:01G
HLA-DQDQA1*01:01:01,03:03:01
DQB1*03:01:01,05:01:01
HLA-DRDRB1*01:01:01,04:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.53
Native American0
East Asian, North2.53
East Asian, South0
South Asian0.58
European, North60.87
European, South35.49
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B5LI (IGR-10)CVCL_RS51 (IGR-1rCDDP2000)CVCL_RS52 (IGR-1rDACARB40)
Sex of cell Male
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): CLS=300219; Cosmic-CLP=907169; DSMZ=ACC-236; PubMed=25056119; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10
D2S133820,22
D3S135814,17
D5S81810,11 (CLS=300219; Cosmic-CLP=907169; DSMZ=ACC-236; PubMed=25877200)
10,14 (PubMed=25056119)
D7S82010,11
D8S117910 (CLS=300219)
10,14 (DSMZ=ACC-236; PubMed=25056119; PubMed=25877200)
D13S31713
D16S53911 (PubMed=25056119)
11,13 (CLS=300219; Cosmic-CLP=907169; DSMZ=ACC-236; PubMed=25877200)
D18S5114,16 (DSMZ=ACC-236; PubMed=25877200)
16 (CLS=300219)
D19S43315,16
D21S1132.2
FGA23,24
Penta D10
Penta E7,11
TH017,9.3 (CLS=300219)
9.3 (Cosmic-CLP=907169; DSMZ=ACC-236; PubMed=25056119; PubMed=25877200)
TPOX8
vWA17,18 (CLS=300219; Cosmic-CLP=907169; DSMZ=ACC-236; PubMed=25877200)
18 (PubMed=25056119)

Run an STR similarity search on this cell line
Publications

PubMed=4153924
Paul Janiaud, Josyane Le Calvez, Christian Aubert;
Cytoenzymological caracterization of cells from human skin melanoma in culture.
Ann. Dermatol. Syphiligr. (Paris) 100:536-539(1973)

PubMed=954556; DOI=10.1016/0014-2964(76)90033-5
Christian Aubert, C. Lagrange, Hans Rorsman, Evald Rosengren;
Catechols in primary and metastatic human malignant melanoma cells in monolayer culture.
Eur. J. Cancer 12:441-445(1976)

PubMed=405430; DOI=10.1111/1523-1747.ep12496554
Colette Foa, Christian Aubert;
Cellular localization of tyrosinase in human malignant melanoma cell lines.
J. Invest. Dermatol. 68:369-378(1977)

PubMed=6929009; DOI=10.1093/jnci/64.5.1029
Christian Aubert, Francoise Rouge, Jean-Remy Galindo;
Tumorigenicity of human malignant melanocytes in nude mice in relation to their differentiation in vitro.
J. Natl. Cancer Inst. 64:1029-1040(1980)

PubMed=1822769; DOI=10.1097/00008390-199104000-00002
Eszter Karg, Gerd Odh, Evald Rosengren, Anna Wittbjer, Hans Rorsman;
Melanin-related biochemistry of IGR 1 human melanoma cells.
Melanoma Res. 1:5-13(1991)

PubMed=11668190; DOI=10.1177/002215540104901105
Hilmar Quentmeier, Mary Osborn, Julia Reinhardt, Margarete Zaborski, Hans Gunther Drexler;
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25056119; DOI=10.1158/0008-5472.CAN-14-1232-T; PMCID=PMC4167745
Ian R. Watson, Li-Ren Li, Peter K. Cabeceiras, Mozhdeh Mahdavi, Tony Gutschner, Giannicola Genovese, Guo-Can Wang, Zhuang-Na Fang, James M. Tepper, Katherine Stemke-Hale, Kenneth Y. Tsai ...Show all 14 authors... , Michael A. Davies, Gordon B. Mills, Lynda Chin; Show fewer authors
The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF.
Cancer Res. 74:4845-4852(2014)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) CLS; 300219
CLS; 300219-SF
DSMZ; ACC-236
Cell line databases/resources CLO; CLO_0006669
CLDB; cl2624
cancercelllines; CVCL_1303
Cell_Model_Passport; SIDM01060
Cosmic-CLP; 907169
DepMap; ACH-000882
DSMZCellDive; ACC-236
LINCS_LDP; LCL-1247
Biological sample resources BioSample; SAMN03472901
BioSample; SAMN10987998
CRISP screens repositories BioGRID_ORCS_Cell_line; 639
Chemistry resources ChEMBL-Cells; CHEMBL3308749
ChEMBL-Targets; CHEMBL1075479
GDSC; 907169
PharmacoDB; IGR1_651_2019
PubChem_Cell_line; CVCL_1303
Encyclopedic resources Wikidata; Q54897358
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887157
GEO; GSM888229
GEO; GSM1669927
Polymorphism and mutation databases Cosmic; 907169
Cosmic; 2230115
IARC_TP53; 21394
LiGeA; CCLE_169
Progenetix; CVCL_1303
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number44