ID   IGR-1
AC   CVCL_1303
SY   IGR 1; IGR1; Institut Gustave Roussy-1
DR   CLO; CLO_0006669
DR   CLDB; cl2624
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 639
DR   BioSample; SAMN03472901
DR   BioSample; SAMN10987998
DR   cancercelllines; CVCL_1303
DR   Cell_Model_Passport; SIDM01060
DR   ChEMBL-Cells; CHEMBL3308749
DR   ChEMBL-Targets; CHEMBL1075479
DR   CLS; 300219
DR   CLS; 300219-SF
DR   Cosmic; 907169
DR   Cosmic; 2230115
DR   Cosmic-CLP; 907169
DR   DepMap; ACH-000882
DR   DSMZ; ACC-236
DR   DSMZCellDive; ACC-236
DR   EGA; EGAS00001000978
DR   GDSC; 907169
DR   GEO; GSM887157
DR   GEO; GSM888229
DR   GEO; GSM1669927
DR   IARC_TP53; 21394
DR   LiGeA; CCLE_169
DR   LINCS_LDP; LCL-1247
DR   PharmacoDB; IGR1_651_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1303
DR   PubChem_Cell_line; CVCL_1303
DR   Wikidata; Q54897358
RX   PubMed=405430;
RX   PubMed=954556;
RX   PubMed=1822769;
RX   PubMed=4153924;
RX   PubMed=6929009;
RX   PubMed=11668190;
RX   PubMed=20164919;
RX   PubMed=22460905;
RX   PubMed=25056119;
RX   PubMed=25877200;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Doubling time: ~75-100 hours (DSMZ=ACC-236).
CC   HLA typing: A*02:01:01,03:01:01; B*11:01:01,44:02:01; C*04:01:01,05:01:01; DPB1*04:01:01G,04:02:01G; DQA1*01:01:01,03:03:01; DQB1*03:01:01,05:01:01; DRB1*01:01:01,04:01:01 (CLS=300219).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Lys (c.1798_1799delGTinsAA); ClinVar=VCV000375941; Zygosity=Heterozygous (PubMed=25056119; Cosmic-CLP=907169; DepMap=ACH-000882).
CC   Sequence variation: Mutation; HGNC; HGNC:9801; RAC1; Simple; p.Pro29Ser (c.85C>T); ClinVar=VCV000376362; Zygosity=Heterozygous (PubMed=25056119; Cosmic-CLP=907169; DepMap=ACH-000882).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.53%; Native American=0%; East Asian, North=2.53%; East Asian, South=0%; South Asian=0.58%; European, North=60.87%; European, South=35.49% (PubMed=30894373).
CC   Derived from site: Metastatic; Inguinal lymph node; UBERON=UBERON_0001542.
ST   Source(s): CLS=300219; Cosmic-CLP=907169; DSMZ=ACC-236; PubMed=25056119; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 13
ST   D16S539: 11 (PubMed=25056119)
ST   D16S539: 11,13 (CLS=300219; Cosmic-CLP=907169; DSMZ=ACC-236; PubMed=25877200)
ST   D18S51: 14,16 (DSMZ=ACC-236; PubMed=25877200)
ST   D18S51: 16 (CLS=300219)
ST   D19S433: 15,16
ST   D21S11: 32.2
ST   D2S1338: 20,22
ST   D3S1358: 14,17
ST   D5S818: 10,11 (CLS=300219; Cosmic-CLP=907169; DSMZ=ACC-236; PubMed=25877200)
ST   D5S818: 10,14 (PubMed=25056119)
ST   D7S820: 10,11
ST   D8S1179: 10 (CLS=300219)
ST   D8S1179: 10,14 (DSMZ=ACC-236; PubMed=25056119; PubMed=25877200)
ST   FGA: 23,24
ST   Penta D: 10
ST   Penta E: 7,11
ST   TH01: 7,9.3 (CLS=300219)
ST   TH01: 9.3 (Cosmic-CLP=907169; DSMZ=ACC-236; PubMed=25056119; PubMed=25877200)
ST   TPOX: 8
ST   vWA: 17,18 (CLS=300219; Cosmic-CLP=907169; DSMZ=ACC-236; PubMed=25877200)
ST   vWA: 18 (PubMed=25056119)
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   42Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 44
CH   CVCL_B5LI ! IGR-10
CH   CVCL_RS51 ! IGR-1rCDDP2000
CH   CVCL_RS52 ! IGR-1rDACARB40
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=1822769; DOI=10.1097/00008390-199104000-00002;
RA   Karg, Eszter
RA   Odh, Gerd
RA   Rosengren, Evald
RA   Wittbjer, Anna
RA   Rorsman, Hans
RT   "Melanin-related biochemistry of IGR 1 human melanoma cells.";
RL   Melanoma Res. 1:5-13(1991).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=11668190; DOI=10.1177/002215540104901105;
RA   Quentmeier, Hilmar
RA   Osborn, Mary
RA   Reinhardt, Julia
RA   Zaborski, Margarete
RA   Drexler, Hans Gunther
RT   "Immunocytochemical analysis of cell lines derived from solid
RT   tumors.";
RL   J. Histochem. Cytochem. 49:1369-1378(2001).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=6929009; DOI=10.1093/jnci/64.5.1029;
RA   Aubert, Christian
RA   Rouge, Francoise
RA   Galindo, Jean-Remy
RT   "Tumorigenicity of human malignant melanocytes in nude mice in
RT   relation to their differentiation in vitro.";
RL   J. Natl. Cancer Inst. 64:1029-1040(1980).
//
RX   PubMed=405430; DOI=10.1111/1523-1747.ep12496554;
RA   Foa, Colette
RA   Aubert, Christian
RT   "Cellular localization of tyrosinase in human malignant melanoma cell
RT   lines.";
RL   J. Invest. Dermatol. 68:369-378(1977).
//
RX   PubMed=954556; DOI=10.1016/0014-2964(76)90033-5;
RA   Aubert, Christian
RA   Lagrange, C.
RA   Rorsman, Hans
RA   Rosengren, Evald
RT   "Catechols in primary and metastatic human malignant melanoma cells in
RT   monolayer culture.";
RL   Eur. J. Cancer 12:441-445(1976).
//
RX   PubMed=4153924;
RA   Janiaud, Paul
RA   Le Calvez, Josyane
RA   Aubert, Christian
RT   "Cytoenzymological caracterization of cells from human skin melanoma
RT   in culture.";
RL   Ann. Dermatol. Syphiligr. (Paris) 100:536-539(1973).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254;
RA   Nusinow, David Paul
RA   Szpyt, John
RA   Ghandi, Mahmoud
RA   Rose, Christopher M.
RA   McDonald, E. Robert 3rd
RA   Kalocsay, Marian
RA   Jane-Valbuena, Judit
RA   Gelfand, Ellen T.
RA   Schweppe, Devin Karl
RA   Jedrychowski, Mark P.
RA   Golji, Javad
RA   Porter, Dale A.
RA   Rejtar, Tomas
RA   Wang, Y. Karen
RA   Kryukov, Gregory V.
RA   Stegmeier, Frank
RA   Erickson, Brian K.
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RA   Gygi, Steven P.
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//
RX   PubMed=25056119; DOI=10.1158/0008-5472.CAN-14-1232-T; PMCID=PMC4167745;
RA   Watson, Ian R.
RA   Li, Li-Ren
RA   Cabeceiras, Peter K.
RA   Mahdavi, Mozhdeh
RA   Gutschner, Tony
RA   Genovese, Giannicola
RA   Wang, Guo-Can
RA   Fang, Zhuang-Na
RA   Tepper, James M.
RA   Stemke-Hale, Katherine
RA   Tsai, Kenneth Y.
RA   Davies, Michael A.
RA   Mills, Gordon B.
RA   Chin, Lynda
RT   "The RAC1 P29S hotspot mutation in melanoma confers resistance to
RT   pharmacological inhibition of RAF.";
RL   Cancer Res. 74:4845-4852(2014).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//