Cellosaurus logo
expasy logo

Cellosaurus HuH-6 Clone 5 (CVCL_1296)

[Text version]
Cell line name HuH-6 Clone 5
Synonyms HuH-6 clone-5; Huh-6 clone 5; HUH-6 Clone 5; HUH-6-clone 5; HUH-6-clone5; HUH6CLONE5; HuH-6 cl-5; HuH-6-cl5; HUH6-Cl-5; HuH-6 cl5; HuH6-Cl5; HUH6 Cl5; HUH6 CL5; Huh6cl5; HuH6-C15; Huh6-c15; HUH6 C15; Huh6c15; JTC38; JTC-38; Japanese Tissue Culture-38
Accession CVCL_1296
Resource Identification Initiative To cite this cell line use: HuH-6 Clone 5 (RRID:CVCL_1296)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Liver Cancer Model Repository (LIMORE).
Population: Japanese.
Doubling time: 25.57 hours (PubMed=31378681); 35 hours (Note=Lot 05262008), 38-55 hours (Note=Lot 12142012), ~37 hours (Note=Lot 07222016) (JCRB=JCRB0401).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Genome sequenced.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly34Val (c.101G>T); ClinVar=VCV000017582; Zygosity=Heterozygous (PubMed=31378681; Cosmic-CLP=907070; DepMap=ACH-002395).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ala159Asp (c.476C>A); ClinVar=VCV001026335; Zygosity=Heterozygous (Cosmic-CLP=907070; DepMap=ACH-002395).
  • Mutation; HGNC; 11998; TP53; Simple; p.Asn239Asp (c.715A>G); ClinVar=VCV000234036; Zygosity=Heterozygous (Cosmic-CLP=907070; DepMap=ACH-002395).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American1.36
East Asian, North76.85
East Asian, South16.52
South Asian0
European, North0
European, South3.49
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4381 (HuH-6)
CVCL_6907 (HB611)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=907070; JCRB=JCRB0401; PubMed=31378681


Run an STR similarity search on this cell line

Doi I.
Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma.
Gann 67:1-10(1976)

PubMed=6161524; DOI=10.18926/AMO/30534
Miyamoto K., Taketa K., Yabe T., Miyano K., Sato J.
Chromosome analysis in a human hepato-blastoma cell line producing alpha-fetoprotein.
Acta Med. Okayama 34:127-130(1980)

PubMed=6290537; DOI=10.1172/JCI110701
Amuro Y., Tanaka M., Higashino K., Hayashi E., Endo T., Kishimoto S., Nakabayashi H., Sato J.
Bile acid synthesis by long-term cultured cell line established from human hepatoblastoma.
J. Clin. Invest. 70:1128-1130(1982)

PubMed=6301464; DOI=10.1016/0006-291X(83)91037-9
Tanaka M., Kawamura K., Fang M.-Q., Higashino K., Kishimoto S., Nakabayashi H., Sato J.
Production of fibronectin by HUH6 C15 cell line established from a human hepatoblastoma.
Biochem. Biophys. Res. Commun. 110:837-841(1983)

PubMed=8835345; DOI=10.1002/(SICI)1096-9071(199602)48:2<133::AID-JMV3>3.0.CO;2-A
Tsuboi S., Nagamori S., Miyazaki M., Mihara K., Fukaya K.-i., Teruya K., Kosaka T., Tsuji T., Namba M.
Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.
J. Med. Virol. 48:133-140(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001
Qiu Z.-X., Li H., Zhang Z.-T., Zhu Z.-F., He S., Wang X.-J., Wang P.-C., Qin J.-J., Zhuang L.-P., Wang W., Xie F.-B., Gu Y., Zou K.-K., Li C., Li C., Wang C.-H., Cen J., Chen X.-T., Shu Y.-J., Zhang Z., Sun L.-L., Min L.-H., Fu Y., Huang X.-W., Lv H., Zhou H., Ji Y., Zhang Z.-G., Meng Z.-Q., Shi X.-L., Zhang H.-B., Li Y.-X., Hui L.-J.
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

Cell line collections (Providers) JCRB; JCRB0401
Cell line databases/resources cancercelllines; CVCL_1296
Cell_Model_Passport; SIDM01257
Cosmic-CLP; 907070
DepMap; ACH-002395
Biological sample resources BioSample; SAMN03471623
Chemistry resources ChEMBL-Cells; CHEMBL3308701
GDSC; 907070
PharmacoDB; HUH6clone5_639_2019
Encyclopedic resources Wikidata; Q54896849
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM2551569
Polymorphism and mutation databases Cosmic; 907070
IARC_TP53; 21384
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number35