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Cellosaurus HuH-6 Clone 5 (CVCL_1296)

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Cell line name HuH-6 Clone 5
Synonyms HuH-6 clone-5; Huh-6 clone 5; HUH-6 Clone 5; HUH-6-clone 5; HUH-6-clone5; HUH6CLONE5; HuH-6 cl-5; HuH-6-cl5; HUH6-Cl-5; HuH-6 cl5; HuH6-Cl5; HUH6 Cl5; HUH6 CL5; Huh6cl5; HuH6-C15; Huh6-c15; HUH6 C15; Huh6c15; JTC38; JTC-38; Japanese Tissue Culture-38
Accession CVCL_1296
Resource Identification Initiative To cite this cell line use: HuH-6 Clone 5 (RRID:CVCL_1296)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Liver Cancer Model Repository (LIMORE).
Population: Japanese.
Doubling time: 25.57 hours (PubMed=31378681); 35 hours (Note=Lot 05262008), 38-55 hours (Note=Lot 12142012), ~37 hours (Note=Lot 07222016) (JCRB=JCRB0401).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly34Val (c.101G>T); ClinVar=VCV000017582; Zygosity=Heterozygous (PubMed=31378681; Cosmic-CLP=907070; DepMap=ACH-002395).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala159Asp (c.476C>A); ClinVar=VCV001026335; Zygosity=Heterozygous (Cosmic-CLP=907070; DepMap=ACH-002395).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asn239Asp (c.715A>G); ClinVar=VCV000234036; Zygosity=Heterozygous (Cosmic-CLP=907070; DepMap=ACH-002395).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.77
Native American1.36
East Asian, North76.85
East Asian, South16.52
South Asian0
European, North0
European, South3.49
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4381 (HuH-6)
Children:
CVCL_6907 (HB611)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=907070; JCRB=JCRB0401; PubMed=31378681

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S8188,11
D7S82011,12
D13S3178,12
D16S53910,11
TH017,8
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=57894
Isao Doi;
Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma.
Gann 67:1-10(1976)

PubMed=6161524; DOI=10.18926/AMO/30534
Kanji Miyamoto, Kazuhisa Taketa, Tamae Yabe, Keiko Miyano, Jiro Sato;
Chromosome analysis in a human hepato-blastoma cell line producing alpha-fetoprotein.
Acta Med. Okayama 34:127-130(1980)

PubMed=6290537; DOI=10.1172/JCI110701; PMCID=PMC370326
Yoshiki Amuro, Masanobu Tanaka, Kazuya Higashino, Eijiro Hayashi, Tomoichiro Endo, Susumu Kishimoto, Hidekazu Nakabayashi, Jiro Sato;
Bile acid synthesis by long-term cultured cell line established from human hepatoblastoma.
J. Clin. Invest. 70:1128-1130(1982)

PubMed=6301464; DOI=10.1016/0006-291X(83)91037-9
Masanobu Tanaka, Kenichi Kawamura, Mei-Qi Fang, Kazuya Higashino, Susumu Kishimoto, Hidekazu Nakabayashi, Jiro Sato;
Production of fibronectin by HUH6 C15 cell line established from a human hepatoblastoma.
Biochem. Biophys. Res. Commun. 110:837-841(1983)

PubMed=8835345; DOI=10.1002/(SICI)1096-9071(199602)48:2<133::AID-JMV3>3.0.CO;2-A
So Tsuboi, Seishi Nagamori, Masahiro Miyazaki, Koichiro Mihara, Ken-ichi Fukaya, Kiichiro Teruya, Tsunenori Kosaka, Takao Tsuji, Masayoshi Namba;
Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.
J. Med. Virol. 48:133-140(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724
Zhi-Xin Qiu, Hong Li, Zheng-Tao Zhang, Zhen-Feng Zhu, Sheng He, Xu-Jun Wang, Peng-Cheng Wang, Jian-Jie Qin, Li-Ping Zhuang, Wei Wang, Fu-Bo Xie ...Show all 33 authors... , Ying Gu, Ke-Ke Zou, Chao Li, Chun Li, Chen-Hua Wang, Jin Cen, Xiao-Tao Chen, Ya-Jing Shu, Zhao Zhang, Lu-Lu Sun, Li-Hua Min, Yong Fu, Xiao-Wu Huang, Hui Lv, He Zhou, Yuan Ji, Zhi-Gang Zhang, Zhi-Qiang Meng, Xiao-Lei Shi, Hai-Bin Zhang, Yi-Xue Li, Li-Jian Hui; Show fewer authors
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

Cross-references
Cell line collections (Providers) JCRB; JCRB0401
Cell line databases/resources cancercelllines; CVCL_1296
Cell_Model_Passport; SIDM01257
Cosmic-CLP; 907070
DepMap; ACH-002395
LIMORE; HuH6
Biological sample resources BioSample; SAMN03471623
Chemistry resources ChEMBL-Cells; CHEMBL3308701
GDSC; 907070
PharmacoDB; HUH6clone5_639_2019
Encyclopedic resources Wikidata; Q54896849
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM2551569
Polymorphism and mutation databases Cosmic; 907070
IARC_TP53; 21384
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37