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Cellosaurus HCC1954 (CVCL_1259)

[Text version]
Cell line name HCC1954
Synonyms HCC-1954; Hamon Cancer Center 1954
Accession CVCL_1259
Resource Identification Initiative To cite this cell line use: HCC1954 (RRID:CVCL_1259)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ICBP43 breast cancer cell line panel.
Part of: JWGray breast cancer cell line panel.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Population: East Indian.
Doubling time: 45 hours (PubMed=25984343); 43.81 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; ChIP-seq; H2BK120ub.
Omics: Genomics; ChIP-seq; H3K23ac.
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K36me3.
Omics: Genomics; ChIP-seq; H3K4me1.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; ChIP-seq; H3K79me2.
Omics: Genomics; ChIP-seq; H3K9ac.
Omics: Genomics; ChIP-seq; H3K9me3.
Omics: Genomics; ChIP-seq; H4K8ac.
Omics: Genomics; Chromosome conformation analysis; Hi-C.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Glycoproteome.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Miscellaneous: Direct author submission of STR profile from Girard, Luc & Gazdar, Adi F.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*24:02,24:02
HLA-BB*35:01,40:06
HLA-CC*04:01,15:02
Class II
HLA-DQDQA1*03:02,01:02
HLA-DRDRB1*16:05,16:05

Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*35:01,40:06
HLA-CC*04:01,15:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.47
Native American0
East Asian, North5.83
East Asian, South0
South Asian78.3
European, North2.65
European, South12.74
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LG20 (HCC1954-LR)CVCL_4W93 (HCC1954-Luc)CVCL_LG21 (HCC1954-NR)
CVCL_VR24 (HCC1954-TGL)CVCL_B3MM (HCC1954/TDR)
Originate from same individual CVCL_1260 ! HCC1954 BL
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2338; Cosmic-CLP=749709; Direct_author_submission; PubMed=25877200; PubMed=28889351; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO10
D1S165615,16 (Technion Genomics Center)
16 (Direct_author_submission)
D2S44110,11
D2S133817 (Direct_author_submission)
17,26 (ATCC=CRL-2338; Technion Genomics Center)
D3S135815,16
D5S81811
D7S82010,11
D8S117912,15
D10S124814 (Direct_author_submission)
14,15 (Technion Genomics Center)
D12S39122
D13S3178,9
D16S5399,11
D18S5114,18
D19S43313,15.2
D21S1128,32.2 (ATCC=CRL-2338; PubMed=25877200; PubMed=28889351; Technion Genomics Center)
32.2 (Direct_author_submission)
D22S104511,15
FGA22,23
Penta D9,12
Penta E12,16
TH016,7
TPOX8,9
vWA18,19

Run an STR similarity search on this cell line
Web pages Info; LINCS; ICBP43; https://lincs.hms.harvard.edu/resources/reagents/icbp43/
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Pawefish; -; https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/HCC1954.html
Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/breast-cancer-xenograft/hcc1954-xenograft-model/
Provider; UT Southwestern; -; https://www.utsouthwestern.edu/edumedia/edufiles/about_us/admin_offices/technology_development/available_technologies/cell-lines.pdf
Publications

PubMed=9833771; DOI=10.1002/(SICI)1097-0215(19981209)78:6<766::AID-IJC15>3.0.CO;2-L
Adi F. Gazdar, Venkatesh Kurvari, Arvind K. Virmani, Lauren S. Gollahon, Masahiro Sakaguchi, Max Westerfield, Dulmini R. Kodagoda, Victor Stasny, H. Thomas Cunningham, Ignacio Ivan Wistuba, Gail E. Tomlinson ...Show all 16 authors... , Vijay Tonk, Raheela Ashfaq, A. Marilyn Leitch, John D. Minna, Jerry W. Shay; Show fewer authors
Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer.
Int. J. Cancer 78:766-774(1998)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Eva Forgacs, Jonathan D. Wren, Craig Kamibayashi, Masashi Kondo, Xie L. Xu, Sanford David Markowitz, Gail E. Tomlinson, Carolyn Y. Muller, Adi F. Gazdar, Harold Ray Garner, John D. Minna;
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=16959974; DOI=10.1126/science.1133427
Tobias Sjoblom, Sian Jones, Laura DeLong Wood, D. Williams Parsons, Jimmy Lin, Thomas D. Barber, Diana Mandelker, Rebecca J. Leary, Janine Ptak, Natalie Silliman, Steve Szabo ...Show all 29 authors... , Phillip Buckhaults, Christopher Farrell, Paul Meeh, Sanford David Markowitz, Joseph E. Willis, Dawn Dawson, James K.V. Willson, Adi F. Gazdar, James Hartigan, Leo Wu, Chang-Sheng Liu, Giovanni Parmigiani, Ben Ho Park, Kurtis E. Bachman, Nickolas Papadopoulos, Bert Vogelstein, Kenneth Wayne Kinzler, Victor E. Velculescu; Show fewer authors
The consensus coding sequences of human breast and colorectal cancers.
Science 314:268-274(2006)

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521
Richard M. Neve, Koei Chin, Jane Fridlyand, Jennifer Yeh, Frederick L. Baehner, Tea Fevr, Laura Clark, Nora Bayani, Jean-Philippe Coppe, Frances Tong, Terry Speed ...Show all 27 authors... , Paul T. Spellman, Sandy DeVries, Anna Lapuk, Nick J. Wang, Wen-Lin Kuo, Jackie L. Stilwell, Daniel Pinkel, Donna G. Albertson, Frederic M. Waldman, Frank McCormick, Robert Brent Dickson, Michael D. Johnson, Marc E. Lippman, Stephen P. Ethier, Adi F. Gazdar, Joe W. Gray; Show fewer authors
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=17932254; DOI=10.1126/science.1145720
Laura DeLong Wood, D. Williams Parsons, Sian Jones, Jimmy Lin, Tobias Sjoblom, Rebecca J. Leary, Dong Shen, Simina M. Boca, Thomas D. Barber, Janine Ptak, Natalie Silliman ...Show all 42 authors... , Steve Szabo, Zoltan Dezso, Vadim Ustyanksky, Tatiana Nikolskaya, Yuri Nikolsky, Rachel Karchin, Paul A. Wilson, Joshua S. Kaminker, Ze-Min Zhang, Randal Croshaw, Joseph E. Willis, Dawn Dawson, Michail Shipitsin, James K.V. Willson, Saraswati Sukumar, Kornelia Polyak, Ben Ho Park, Charit L. Pethiyagoda, P.V. Krishna Pant, Dennis G. Ballinger, Andrew B. Sparks, James Hartigan, Douglas R. Smith, Erick Suh, Nickolas Papadopoulos, Phillip Buckhaults, Sanford David Markowitz, Giovanni Parmigiani, Kenneth Wayne Kinzler, Victor E. Velculescu, Bert Vogelstein; Show fewer authors
The genomic landscapes of human breast and colorectal cancers.
Science 318:1108-1113(2007)

PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084
Jessica Kao, Keyan Salari, Melanie Bocanegra, Yoon-La Choi, Luc Girard, Jeet Gandhi, Kevin A. Kwei, Tina Hernandez-Boussard, Pei Wang, Adi F. Gazdar, John D. Minna, Jonathan R. Pollack;
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
PLoS ONE 4:e6146.1-e6146.16(2009)

PubMed=20070913; DOI=10.1186/1471-2407-10-15; PMCID=PMC2836299
Katumi Tsuji, Shigeto Kawauchi, Soichiro Saito, Tomoko Furuya, Kenzo Ikemoto, Motonao Nakao, Shigeru Yamamoto, Masaaki Oka, Takashi Hirano, Kohsuke Sasaki;
Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: comparison of the CGH profiles between cancer cell lines and primary cancer tissues.
BMC Cancer 10:15.1-15.10(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21378333
Christopher H.J. Ford, Maie Al-Bader, Bushra Al-Ayadhi, Issam Francis;
Reassessment of estrogen receptor expression in human breast cancer cell lines.
Anticancer Res. 31:521-527(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396
Richard Marcotte, Kevin R. Brown, Fernando Jose Suarez Saiz, Azin Sayad, Konstantina Karamboulas, Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice Lie-Yong Koh, Dewald van Dyk ...Show all 28 authors... , Bohdana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia Mero, Christine Misquitta, Josee Normand, Maliha Haider, Troy Ketela, Jeffrey L. Wrana, Robert Rottapel, Benjamin G. Neel, Jason Moffat; Show fewer authors
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2:172-189(2012)

PubMed=23151021; DOI=10.1186/1471-2164-13-619; PMCID=PMC3546428
Anita Grigoriadis, Alan Mackay, Elodie Noel, Pei-Jun Wu, Rachael Natrajan, Jessica Frankum, Jorge Sergio Reis-Filho, Andrew Tutt;
Molecular characterisation of cell line models for triple-negative breast cancers.
BMC Genomics 13:619.1-619.14(2012)

PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661
Muhammad Riaz, Marijn T.M. van Jaarsveld, Antoinette Hollestelle, Wendy J.C. Prager-van der Smissen, Anouk A.J. Heine, Antonius W.M. Boersma, Jing-Jing Liu, Jean C.A. Helmijr, Bahar Ozturk, Marcel Smid, Erik A.C. Wiemer ...Show all 13 authors... , John A. Foekens, John W.M. Martens; Show fewer authors
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33.1-R33.17(2013)

PubMed=23637631; DOI=10.1371/journal.pgen.1003464; PMCID=PMC3636093
Craig P. Giacomini, Steven Sun, Sushama Varma, Alan Hunter Shain, Marilyn M. Giacomini, Jay Michael S. Balagtas, Robert T. Sweeney, Everett Lai, Catherine A. Del Vecchio, Andrew D. Forster, Nicole Clarke ...Show all 17 authors... , Kelli D. Montgomery, Shirley Zhu, Albert J. Wong, Matt van de Rijn, Robert B. West, Jonathan R. Pollack; Show fewer authors
Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types.
PLoS Genet. 9:e1003464.1-e1003464.19(2013)

PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310
Luika A. Timmerman, Thomas Holton, Mariia Yuneva, Raymond J. Louie, Merce Padro, Anneleen Daemen, Min Hu, Denise A. Chan, Stephen P. Ethier, Laura J. van 't Veer, Kornelia Polyak ...Show all 13 authors... , Frank McCormick, Joe W. Gray; Show fewer authors
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.
Cancer Cell 24:450-465(2013)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3; PMCID=PMC3832776
Aleix Prat, Olga Karginova, Joel S. Parker, Cheng Fan, Xia-Ping He, Lisa M. Bixby, J. Chuck Harrell, Erick Roman, Barbara Adamo, Melissa A. Troester, Charles M. Perou;
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590
Anneleen Daemen, Obi L. Griffith, Laura M. Heiser, Nicholas J. Wang, Oana M. Enache, Zachary Sanborn, Francois Pepin, Steffen Durinck, James E. Korkola, Malachi Griffith, Joe S. Hur ...Show all 27 authors... , Nam Huh, Jongsuk Chung, Leslie Cope, Mary Jo Fackler, Christopher Benedict Umbricht, Saraswati Sukumar, Pankaj Seth, Vikas P. Sukhatme, Lakshmi R. Jakkula, Yi-Ling Lu, Gordon B. Mills, Raymond J. Cho, Eric A. Collisson, Laura J. van 't Veer, Paul T. Spellman, Joe W. Gray; Show fewer authors
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28287265; DOI=10.1021/acs.jproteome.6b00470; PMCID=PMC5557415
Ten-Yang Yen, Spencer Bowen, Roger Yen, Alexandra Piryatinska, Bruce A. Macher, Leslie C. Timpe;
Glycoproteins in claudin-low breast cancer cell lines have a unique expression profile.
J. Proteome Res. 16:1391-1400(2017)

PubMed=28889351; DOI=10.1007/s10549-017-4496-x
Jodi M. Saunus, Chanel E. Smart, Jamie R. Kutasovic, Rebecca L. Johnston, Priyakshi Kalita-de Croft, Mariska Miranda, Esdy N. Rozali, Ana Cristina Vargas, Lynne E. Reid, Eva Lorsy, Sibylle Cocciardi ...Show all 23 authors... , Tatjana Seidens, Amy Ellen McCart Reed, Andrew J. Dalley, Leesa F. Wockner, Julie Johnson, Debina Sarkar, Marjan E. Askarian-Amiri, Peter T. Simpson, Kum Kum Khanna, Georgia Chenevix-Trench, Fares Al-Ejeh, Sunil R. Lakhani; Show fewer authors
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
Breast Cancer Res. Treat. 167:289-301(2018)

PubMed=29273624; DOI=10.1101/gr.226019.117; PMCID=PMC5793780
Hector L. Franco, Anusha Nagari, Venkat S. Malladi, Wen-Qian Li, Yuan-Xin Xi, Dana Richardson, Kendra L. Allton, Kaori Tanaka, Jing Li, Shino Murakami, Khandan Keyomarsi ...Show all 17 authors... , Mark T. Bedford, Xiao-Bing Shi, Wei Li, Michelle C. Barton, Sharon Yoder Roth Dent, W. Lee Kraus; Show fewer authors
Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis.
Genome Res. 28:159-170(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2338
BCRJ; 0280
CLS; 305268
KCLB; 9S1954
Cell line databases/resources CLO; CLO_0003647
cancercelllines; CVCL_1259
Cell_Model_Passport; SIDM00872
Cosmic-CLP; 749709
DepMap; ACH-000859
IGRhCellID; HCC1954
LINCS_HMS; 50213
LINCS_LDP; LCL-1332
Lonza; 1357
SLKBase; 3543
Anatomy/cell type resources BTO; BTO_0005368
Biological sample resources BioSample; SAMN03473018
BioSample; SAMN10987850
CRISP screens repositories BioGRID_ORCS_Cell_line; 425
Chemistry resources ChEMBL-Cells; CHEMBL3308107
ChEMBL-Targets; CHEMBL1075459
GDSC; 749709
PharmacoDB; HCC1954_486_2019
PubChem_Cell_line; CVCL_1259
Encyclopedic resources Wikidata; Q54881618
Experimental variables resources EFO; EFO_0001175
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-TABM-157
GEO; GSM185081
GEO; GSM185082
GEO; GSM186724
GEO; GSM217578
GEO; GSM219962
GEO; GSM274675
GEO; GSM303673
GEO; GSM303675
GEO; GSM303680
GEO; GSM303682
GEO; GSM303684
GEO; GSM303687
GEO; GSM303689
GEO; GSM303691
GEO; GSM303695
GEO; GSM303698
GEO; GSM303700
GEO; GSM303704
GEO; GSM303707
GEO; GSM303709
GEO; GSM303712
GEO; GSM303715
GEO; GSM303719
GEO; GSM303721
GEO; GSM303723
GEO; GSM303726
GEO; GSM303729
GEO; GSM303731
GEO; GSM303735
GEO; GSM303738
GEO; GSM303740
GEO; GSM303742
GEO; GSM303745
GEO; GSM303747
GEO; GSM303750
GEO; GSM303753
GEO; GSM303754
GEO; GSM303760
GEO; GSM303762
GEO; GSM303766
GEO; GSM303769
GEO; GSM303770
GEO; GSM303775
GEO; GSM303777
GEO; GSM303780
GEO; GSM303784
GEO; GSM303786
GEO; GSM303789
GEO; GSM337683
GEO; GSM337684
GEO; GSM337685
GEO; GSM337686
GEO; GSM337687
GEO; GSM337688
GEO; GSM337689
GEO; GSM337690
GEO; GSM337691
GEO; GSM337692
GEO; GSM337693
GEO; GSM337694
GEO; GSM337695
GEO; GSM344374
GEO; GSM344424
GEO; GSM350499
GEO; GSM481299
GEO; GSM718290
GEO; GSM783937
GEO; GSM847341
GEO; GSM847483
GEO; GSM887046
GEO; GSM888116
GEO; GSM1008901
GEO; GSM1053712
GEO; GSM1172871
GEO; GSM1172962
GEO; GSM1215272
GEO; GSM1374508
GEO; GSM1374509
GEO; GSM1401665
GEO; GSM1669852
GEO; GSM2258830
GEO; GSM2258831
GEO; GSM2258832
GEO; GSM2258833
GEO; GSM2258834
GEO; GSM2258835
GEO; GSM2258836
GEO; GSM2258837
GEO; GSM2258838
GEO; GSM2258839
GEO; GSM2258840
GEO; GSM2258841
GEO; GSM2258842
GEO; GSM2258843
GEO; GSM2258844
GEO; GSM2258845
GEO; GSM2258846
GEO; GSM2258847
GEO; GSM2258929
GEO; GSM2258930
GEO; GSM2258931
GEO; GSM3258551
Polymorphism and mutation databases Cosmic; 749709
Cosmic; 904369
Cosmic; 1136367
Cosmic; 1235077
Cosmic; 1287889
Cosmic; 1308993
Cosmic; 1430345
Cosmic; 1473150
Cosmic; 1518107
Cosmic; 1603208
Cosmic; 1717243
Cosmic; 1935009
Cosmic; 1995428
Cosmic; 2165007
IARC_TP53; 21363
LiGeA; CCLE_705
Progenetix; CVCL_1259
Proteomic databases PRIDE; PXD002486
PRIDE; PXD005339
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number52