Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > HCC1954

HCC1954   [Cellosaurus entry CVCL_1259]

Breast Cancer Cell Line


A tetraploid cell line from mammary gland, breast, duct, ductal carcinoma, extremely rearranged with 35 structural chromosome rearrangements involving all chromosomes except 11 and 16, with hsrs involving chromosomes 8, 21 and 22. Held by ATCC.

Notable Features

Representative SKY Karyotype

90(89-94), XX, der(X?)t(X;38), der(X?)t(X; ?;2;5?;1)??, 1x3, der(1)t(1;5), der(1)t(1;10), der(1)t(1;?3?;5;?X), 2x1, del(2), der(2;8;17), der(2)t(2;8;4), 3x2, der(3)del(3), 4x2, der(4)t(3;4;13/18;1)?, del(4), 5x3, i(5p)?, del(5)t(5;?)?, 6x4, der(6)del(6)(q10-qter), 7x5, 8x1, der(8)t(5;8), del(8)(p10-pter), der(8)t(13;8;9)?, 9x2, der(9)t(20, 9hsr,X/5/22?)x2, der(9)t(9q;8p), 10x3, der(10?)t(7p;10p)a, 11x3, 12x2, der(12)del(12)(p10-pter), 13x2, der(13;17)(q10;q10), i(14q)t(14;1;14) b, der(14)t(14q;22hsr;5q), 15x3, der(15;19)(q10;q10), 16x4, 17x4, i(17q)/isoder(17;10)??, der(17)t(17;10/22?), 18x3, der(18)t(9;18), 19x1, der(19)t(18;19), der(19)t(19;8;17), der(19)t(19;8;3), der(19)t(2/X;19), 20x2, der(20)t(20;19;5), der(16;21)(q10;q10); der(14;21)(q10;q10), 22x2, der(22)t(5;22), der(22)t(22;hsr8?;hsr21?)

a  in less than 50% of the cells
b  i(14q) has a strip of chr 1 on one arm and is probably more complex




Breast Cancer Cell Lines