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Cellosaurus C8166 (CVCL_1099)

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Cell line name C8166
Synonyms C8166-CD4
Accession CVCL_1099
Resource Identification Initiative To cite this cell line use: C8166 (RRID:CVCL_1099)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Umbilical cord blood.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.05
East Asian, North1.72
East Asian, South0
South Asian0
European, North64.43
European, South33.5
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0195 (C8166/45 )CVCL_A6UT (C8166/CCR5 )CVCL_1H07 (M8166 )
Sex of cell Male
Age at sampling <1D
Category Transformed cell line
Web pages http://www.nibsc.org/Default.aspx?pageid=597&id=0013&theme=default

PubMed=6412453; DOI=10.1016/0042-6822(83)90395-1
Salahuddin S.Z., Markham P.D., Wong-Staal F., Franchini G., Kalyanaraman V.S., Gallo R.C.
Restricted expression of human T-cell leukemia/lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes.
Virology 129:51-64(1983)

PubMed=12920029; DOI=10.1182/blood-2003-04-1043
Chung H.-K., Young H.A., Goon P.K.C., Heidecker G., Princler G.L., Shimozato O., Taylor G.P., Bangham C.R.M., Derse D.D.
Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines.
Blood 102:4130-4136(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections ECACC; 88051601
KCB; KCB 94019YJ
Cell line databases/resources CLO; CLO_0002149
CLDB; cl589
Cell_Model_Passport; SIDM00072
DepMap; ACH-000206
Biological sample resources BioSample; SAMN10989599
Chemistry resources ChEMBL-Cells; CHEMBL3307638
ChEMBL-Targets; CHEMBL614533
PharmacoDB; C8166_157_2019
Encyclopedic resources Wikidata; Q54808257
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827337
GEO; GSM1669640
Polymorphism and mutation databases Cosmic; 906829
IARC_TP53; 21206
Progenetix; CVCL_1099
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number30