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Cellosaurus C8166 (CVCL_1099)

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Cell line name C8166
Synonyms C8166-CD4
Accession CVCL_1099
Resource Identification Initiative To cite this cell line use: C8166 (RRID:CVCL_1099)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Umbilical cord blood; UBERON=UBERON_0012168.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (DepMap=ACH-000206).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.3
Native American0.05
East Asian, North1.72
East Asian, South0
South Asian0
European, North64.43
European, South33.5
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0195 (C8166/45)CVCL_A6UT (C8166/CCR5)CVCL_1H07 (M8166)
Sex of cell Male
Age at sampling <1D
Category Transformed cell line
Web pages Provider; NIBSC; 0013; https://nibsc.org/Default.aspx?pageid=597&id=0013&theme=default
Publications

PubMed=6412453; DOI=10.1016/0042-6822(83)90395-1
Syed Zaki Salahuddin, Phillip D. Markham, Flossie Wong-Staal, Genoveffa Franchini, Vaniambadi S. Kalyanaraman, Robert Charles Gallo;
Restricted expression of human T-cell leukemia/lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes.
Virology 129:51-64(1983)

PubMed=12920029; DOI=10.1182/blood-2003-04-1043
Hye-Kyung Chung, Howard A. Young, Peter Kin Cho Goon, Gisela Heidecker, Gerald Lee Princler, Osamu Shimozato, Graham P. Taylor, Charles R.M. Bangham, David Daniel Derse;
Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines.
Blood 102:4130-4136(2003)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ECACC; 88051601
KCB; KCB 94019YJ
Cell line databases/resources CLO; CLO_0002149
CLDB; cl589
cancercelllines; CVCL_1099
Cell_Model_Passport; SIDM00072
DepMap; ACH-000206
LINCS_LDP; LCL-1011
Biological sample resources BioSample; SAMN10989599
Chemistry resources ChEMBL-Cells; CHEMBL3307638
ChEMBL-Targets; CHEMBL614533
PharmacoDB; C8166_157_2019
PubChem_Cell_line; CVCL_1099
Encyclopedic resources Wikidata; Q54808257
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827337
GEO; GSM1669640
Polymorphism and mutation databases Cosmic; 906829
IARC_TP53; 21206
Progenetix; CVCL_1099
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37