ID   C8166
AC   CVCL_1099
SY   C8166-CD4
DR   CLO; CLO_0002149
DR   CLDB; cl589
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN10989599
DR   cancercelllines; CVCL_1099
DR   Cell_Model_Passport; SIDM00072
DR   ChEMBL-Cells; CHEMBL3307638
DR   ChEMBL-Targets; CHEMBL614533
DR   Cosmic; 906829
DR   DepMap; ACH-000206
DR   ECACC; 88051601
DR   EGA; EGAS00001000978
DR   GEO; GSM827337
DR   GEO; GSM1669640
DR   IARC_TP53; 21206
DR   KCB; KCB 94019YJ
DR   LINCS_LDP; LCL-1011
DR   PharmacoDB; C8166_157_2019
DR   Progenetix; CVCL_1099
DR   PubChem_Cell_line; CVCL_1099
DR   Wikidata; Q54808257
RX   PubMed=6412453;
RX   PubMed=12920029;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   http://www.nibsc.org/Default.aspx?pageid=597&id=0013&theme=default
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (DepMap).
CC   Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
CC   Omics: Deep exome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=0.3%; Native American=0.05%; East Asian, North=1.72%; East Asian, South=0%; South Asian=0%; European, North=64.43%; European, South=33.5% (PubMed=30894373).
CC   Derived from site: In situ; Umbilical cord blood; UBERON=UBERON_0012168.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   <1D
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 34
//
RX   PubMed=6412453; DOI=10.1016/0042-6822(83)90395-1;
RA   Salahuddin S.Z., Markham P.D., Wong-Staal F., Franchini G.,
RA   Kalyanaraman V.S., Gallo R.C.;
RT   "Restricted expression of human T-cell leukemia/lymphoma virus (HTLV)
RT   in transformed human umbilical cord blood lymphocytes.";
RL   Virology 129:51-64(1983).
//
RX   PubMed=12920029; DOI=10.1182/blood-2003-04-1043;
RA   Chung H.-K., Young H.A., Goon P.K.C., Heidecker G., Princler G.L.,
RA   Shimozato O., Taylor G.P., Bangham C.R.M., Derse D.D.;
RT   "Activation of interleukin-13 expression in T cells from
RT   HTLV-1-infected individuals and in chronically infected cell lines.";
RL   Blood 102:4130-4136(2003).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//