Cellosaurus logo
expasy logo

Cellosaurus C-33 A (CVCL_1094)

[Text version]
Cell line name C-33 A
Synonyms C33A; C33a; C33-A; C-33-A; C-33A; C33
Accession CVCL_1094
Resource Identification Initiative To cite this cell line use: C-33 A (RRID:CVCL_1094)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
Population: Caucasian.
Doubling time: 1.36 days (PubMed=29156801).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Secretome; 2DE-MS.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,03:01
HLA-BB*07:02,44:02
HLA-CC*05:01,07:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.41
Native American0.33
East Asian, North0.48
East Asian, South0.19
South Asian0.82
European, North66.58
European, South31.19
Disease Human papillomavirus-independent cervical squamous cell carcinoma (NCIt: C180841)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4J71 (HOE6V)CVCL_X008 (SK-OV-4)CVCL_A457 (SK-OV-6)
Originate from same individual CVCL_1E27 ! C-33 B
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0008003/382; ATCC=HTB-31; CCRID; Cosmic-CLP=687505; DepMap=ACH-001333; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D2S133823,25
D3S135816
D5S81811,12
D7S82010
D8S117910,14
D13S31713
D16S53913,14
D18S5115,17,18 (DepMap=ACH-001333)
15,18 (ATCC=HTB-31; PubMed=25877200)
D19S43311,13,14
D21S1129,30,31
FGA21,25,26 (ATCC=HTB-31)
21,26 (CCRID; PubMed=25877200)
Penta D10
Penta E6,8
TH017,8
TPOX9
vWA18,20

Run an STR similarity search on this cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-23.html
Publications

PubMed=14114965; DOI=10.1093/jnci/32.1.135
Nelly Auersperg;
Long-term cultivation of hypodiploid human tumor cells.
J. Natl. Cancer Inst. 32:135-163(1964)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
William C. Wright, Walter P. Daniels, Jorgen Fogh;
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7459858
Monique Rousset, Alain Zweibaum, Jorgen Fogh;
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=2990217; PMCID=PMC1888002
Carole Yee, Indira Krishnan-Hewlett, Carl C. Baker, Richard Schlegel, Peter Maxwell Howley;
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=1648218; DOI=10.1073/pnas.88.13.5523; PMCID=PMC51909
Martin Scheffner, Karl Munger, Janet C. Byrne, Peter Maxwell Howley;
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
Proc. Natl. Acad. Sci. U.S.A. 88:5523-5527(1991)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Stefan E. Baldus, Elisabeth Schwarz, Claudia Lohrey, Marc Zapatka, Stephanie Landsberg, Stephan A. Hahn, Dietmar Schmidt, Hans-Peter Dienes, Wolff Helmut Schmiegel, Irmgard Schwarte-Waldhoff;
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24134916; DOI=10.1186/1755-8166-6-44; PMCID=PMC3879223
Amanda McCormack, Jiang-Lan Fan, Max Duesberg, Mathew Bloomfield, Christian Fiala, Peter Heinz Duesberg;
Individual karyotypes at the origins of cervical carcinomas.
Mol. Cytogenet. 6:44.1-44.23(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28261610; DOI=10.1155/2017/4180703; PMCID=PMC5316418
Georgia Kontostathi, Jerome Zoidakis, Manousos Makridakis, Vasiliki Lygirou, Georgios Mermelekas, Theofilos Papadopoulos, Konstantinos Vougas, Alexios Vlamis-Gardikas, Peter Drakakis, Dimitrios Loutradis, Antonia Vlahou ...Show all 13 authors... , Nicholas P. Anagnou, Kalliopi I. Pappa; Show fewer authors
Cervical cancer cell line secretome highlights the roles of transforming growth factor-beta-induced protein ig-h3, peroxiredoxin-2, and NRF2 on cervical carcinogenesis.
BioMed Res. Int. 2017:4180703.1-4180703.15(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35692560; DOI=10.1080/23723556.2022.2078628; PMCID=PMC9176225
Ma de Lourdes Zuniga-Martinez, Carlos Miguel Lopez-Mendoza, Jared Tenorio-Salazar, Alejandro Manuel Garcia-Carranca, Marco Antonio Cerbon-Cervantes, Luz Eugenia Alcantara-Quintana;
Establishment, authenticity, and characterization of cervical cancer cell lines.
Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0008003/382
ATCC; CRM-HTB-31
ATCC; HTB-31
BCRC; 60554
BCRJ; 0348
CCTCC; GDC0144
CLS; 305072
ICLC; HTL02004
Cell line databases/resources CLO; CLO_0002115
CLDB; cl7126
cancercelllines; CVCL_1094
CCRID; 1101HUM-PUMC000172
CCRID; 1102HUM-NIFDC00091
CCRID; 3101HUMTCHu176
CCRID; 4201HUM-CCTCC00144
Cell_Model_Passport; SIDM00889
Cosmic-CLP; 687505
DepMap; ACH-001333
IGRhCellID; C33A
LINCS_LDP; LCL-1300
Anatomy/cell type resources BTO; BTO_0001968
Biological sample resources BioSample; SAMN03473073
Chemistry resources ChEMBL-Cells; CHEMBL3308230
ChEMBL-Targets; CHEMBL2366313
ChEMBL-Targets; CHEMBL614370
GDSC; 687505
PharmacoDB; C33A_150_2019
PubChem_Cell_line; CVCL_1094
Encyclopedic resources Wikidata; Q54799738
Experimental variables resources EFO; EFO_0002120
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM253296
GEO; GSM675730
GEO; GSM685441
GEO; GSM1669637
Polymorphism and mutation databases Cosmic; 687505
Cosmic; 760217
Cosmic; 809226
Cosmic; 846180
Cosmic; 877470
Cosmic; 925355
Cosmic; 928905
Cosmic; 1071910
Cosmic; 1131520
Cosmic; 1176610
Cosmic; 1193030
Cosmic; 1201776
Cosmic; 1324210
Cosmic; 1995353
Cosmic; 2301537
Cosmic; 2602729
Cosmic; 2660188
Cosmic; 2791020
Cosmic; 2816218
IARC_TP53; 324
Progenetix; CVCL_1094
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number49