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Cellosaurus SK-OV-4 (CVCL_X008)

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Cell line name SK-OV-4
Synonyms SKOV-4; SKOV4
Accession CVCL_X008
Resource Identification Initiative To cite this cell line use: SK-OV-4 (RRID:CVCL_X008)
Comments Problematic cell line: Contaminated. Shown to be a C-33 A derivative (PubMed=22710073).
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00469.
Population: Caucasian.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (from parent cell line).
Disease Human papillomavirus-independent cervical squamous cell carcinoma (NCIt: C180841)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1094 (C-33 A)
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_X008
Biological sample resources BioSample; SAMN03151613
Encyclopedic resources Wikidata; Q54954503
Gene expression databases GEO; GSM851941
Entry history
Entry creation17-Jul-2014
Last entry update10-Apr-2025
Version number24