ID   C-33 A
AC   CVCL_1094
SY   C33A; C33a; C33-A; C-33-A; C-33A; C33
DR   BTO; BTO_0001968
DR   CLO; CLO_0002115
DR   EFO; EFO_0002120
DR   CLDB; cl7126
DR   AddexBio; C0008003/382
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRM-HTB-31
DR   ATCC; HTB-31
DR   BCRC; 60554
DR   BCRJ; 0348
DR   BioSample; SAMN03473073
DR   cancercelllines; CVCL_1094
DR   CCRID; 1101HUM-PUMC000172
DR   CCRID; 1102HUM-NIFDC00091
DR   CCRID; 3101HUMTCHu176
DR   CCRID; 4201HUM-CCTCC00144
DR   CCTCC; GDC0144
DR   Cell_Model_Passport; SIDM00889
DR   ChEMBL-Cells; CHEMBL3308230
DR   ChEMBL-Targets; CHEMBL2366313
DR   ChEMBL-Targets; CHEMBL614370
DR   CLS; 305072
DR   Cosmic; 687505
DR   Cosmic; 760217
DR   Cosmic; 809226
DR   Cosmic; 846180
DR   Cosmic; 877470
DR   Cosmic; 925355
DR   Cosmic; 928905
DR   Cosmic; 1071910
DR   Cosmic; 1131520
DR   Cosmic; 1176610
DR   Cosmic; 1193030
DR   Cosmic; 1201776
DR   Cosmic; 1324210
DR   Cosmic; 1995353
DR   Cosmic; 2301537
DR   Cosmic; 2602729
DR   Cosmic; 2660188
DR   Cosmic; 2791020
DR   Cosmic; 2816218
DR   Cosmic-CLP; 687505
DR   DepMap; ACH-001333
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 687505
DR   GEO; GSM253296
DR   GEO; GSM675730
DR   GEO; GSM685441
DR   GEO; GSM1669637
DR   IARC_TP53; 324
DR   ICLC; HTL02004
DR   IGRhCellID; C33A
DR   LINCS_LDP; LCL-1300
DR   PharmacoDB; C33A_150_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1094
DR   PubChem_Cell_line; CVCL_1094
DR   Wikidata; Q54799738
RX   PubMed=327080;
RX   PubMed=833871;
RX   PubMed=1648218;
RX   PubMed=2990217;
RX   PubMed=3518877;
RX   PubMed=6935474;
RX   PubMed=7459858;
RX   PubMed=14114965;
RX   PubMed=15531914;
RX   PubMed=20215515;
RX   PubMed=24134916;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=28261610;
RX   PubMed=29156801;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=35692560;
RX   PubMed=35839778;
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-23.html
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
CC   Population: Caucasian.
CC   Doubling time: 1.36 days (PubMed=29156801).
CC   HLA typing: A*02:01,03:01; B*07:02,44:02; C*05:01,07:02 (PubMed=26589293).
CC   Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=1648218).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Proteomics; Subcellular; Secretome; 2DE-MS.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.41%; Native American=0.33%; East Asian, North=0.48%; East Asian, South=0.19%; South Asian=0.82%; European, North=66.58%; European, South=31.19% (PubMed=30894373).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): AddexBio=C0008003/382; ATCC=HTB-31; CCRID; Cosmic-CLP=687505; DepMap=ACH-001333; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 13
ST   D16S539: 13,14
ST   D18S51: 15,17,18 (DepMap=ACH-001333)
ST   D18S51: 15,18 (ATCC=HTB-31; PubMed=25877200)
ST   D19S433: 11,13,14
ST   D21S11: 29,30,31
ST   D2S1338: 23,25
ST   D3S1358: 16
ST   D5S818: 11,12
ST   D7S820: 10
ST   D8S1179: 10,14
ST   FGA: 21,25,26 (ATCC=HTB-31)
ST   FGA: 21,26 (CCRID; PubMed=25877200)
ST   Penta D: 10
ST   Penta E: 6,8
ST   TH01: 7,8
ST   TPOX: 9
ST   vWA: 18,20
DI   NCIt; C180841; Human papillomavirus-independent cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1E27 ! C-33 B
SX   Female
AG   66Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 49
CH   CVCL_4J71 ! HOE6V
CH   CVCL_X008 ! SK-OV-4
CH   CVCL_A457 ! SK-OV-6
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright, William C.
RA   Daniels, Walter P.
RA   Fogh, Jorgen
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=2990217; PMCID=PMC1888002;
RA   Yee, Carole
RA   Krishnan-Hewlett, Indira
RA   Baker, Carl C.
RA   Schlegel, Richard
RA   Howley, Peter Maxwell
RT   "Presence and expression of human papillomavirus sequences in human
RT   cervical carcinoma cell lines.";
RL   Am. J. Pathol. 119:361-366(1985).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=1648218; DOI=10.1073/pnas.88.13.5523; PMCID=PMC51909;
RA   Scheffner, Martin
RA   Munger, Karl
RA   Byrne, Janet C.
RA   Howley, Peter Maxwell
RT   "The state of the p53 and retinoblastoma genes in human cervical
RT   carcinoma cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:5523-5527(1991).
//
RX   PubMed=15531914; DOI=10.1038/sj.onc.1208235;
RA   Baldus, Stefan E.
RA   Schwarz, Elisabeth
RA   Lohrey, Claudia
RA   Zapatka, Marc
RA   Landsberg, Stephanie
RA   Hahn, Stephan A.
RA   Schmidt, Dietmar
RA   Dienes, Hans-Peter
RA   Schmiegel, Wolff Helmut
RA   Schwarte-Waldhoff, Irmgard
RT   "Smad4 deficiency in cervical carcinoma cells.";
RL   Oncogene 24:810-819(2005).
//
RX   PubMed=35692560; DOI=10.1080/23723556.2022.2078628; PMCID=PMC9176225;
RA   de Lourdes Zuniga-Martinez, Ma
RA   Lopez-Mendoza, Carlos Miguel
RA   Tenorio-Salazar, Jared
RA   Garcia-Carranca, Alejandro Manuel
RA   Cerbon-Cervantes, Marco Antonio
RA   Alcantara-Quintana, Luz Eugenia
RT   "Establishment, authenticity, and characterization of cervical cancer
RT   cell lines.";
RL   Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).
//
RX   PubMed=14114965; DOI=10.1093/jnci/32.1.135;
RA   Auersperg, Nelly
RT   "Long-term cultivation of hypodiploid human tumor cells.";
RL   J. Natl. Cancer Inst. 32:135-163(1964).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh, Jorgen
RA   Wright, William C.
RA   Loveless, James D.
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=24134916; DOI=10.1186/1755-8166-6-44; PMCID=PMC3879223;
RA   McCormack, Amanda
RA   Fan, Jiang-Lan
RA   Duesberg, Max
RA   Bloomfield, Mathew
RA   Fiala, Christian
RA   Duesberg, Peter Heinz
RT   "Individual karyotypes at the origins of cervical carcinomas.";
RL   Mol. Cytogenet. 6:44.1-44.23(2013).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu, Nene N.
RA   Mazumdar, Tuhina
RA   Peng, Shao-Hua
RA   Shen, Li
RA   Sambandam, Vaishnav
RA   Rao, Xia-Yu
RA   Xi, Yuan-Xin
RA   Li, Le-Rong
RA   Qi, Yuan
RA   Gleber-Netto, Frederico O.
RA   Patel, Ameeta
RA   Wang, Jing
RA   Frederick, Mitchell J.
RA   Myers, Jeffrey N.
RA   Pickering, Curtis R.
RA   Johnson, Faye M.
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=28261610; DOI=10.1155/2017/4180703; PMCID=PMC5316418;
RA   Kontostathi, Georgia
RA   Zoidakis, Jerome
RA   Makridakis, Manousos
RA   Lygirou, Vasiliki
RA   Mermelekas, Georgios
RA   Papadopoulos, Theofilos
RA   Vougas, Konstantinos
RA   Vlamis-Gardikas, Alexios
RA   Drakakis, Peter
RA   Loutradis, Dimitrios
RA   Vlahou, Antonia
RA   Anagnou, Nicholas P.
RA   Pappa, Kalliopi I.
RT   "Cervical cancer cell line secretome highlights the roles of
RT   transforming growth factor-beta-induced protein ig-h3,
RT   peroxiredoxin-2, and NRF2 on cervical carcinogenesis.";
RL   BioMed Res. Int. 2017:4180703.1-4180703.15(2017).
//
RX   PubMed=7459858;
RA   Rousset, Monique
RA   Zweibaum, Alain
RA   Fogh, Jorgen
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh, Jorgen
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh, Jorgen
RA   Fogh, Jens M.
RA   Orfeo, Thomas
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//