Cellosaurus ACN (CVCL_1068)
| Cell line name | ACN | ||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Accession | CVCL_1068 | ||||||||||||||||||||||||||||||||
| Resource Identification Initiative | To cite this cell line use: ACN (RRID:CVCL_1068) | ||||||||||||||||||||||||||||||||
| Comments | Problematic cell line: Probably contaminated. The STR profile of ACN and LN-464 are identical. SNP analysis (DepMap) also shows identity of both cell lines. We believe this is a melanoma cell line based on the presence of the BRAF V600E mutation as well as the RNASeq expression profile of LN-464 (DepMap) which clusters with that of melanoma patient samples. Originally thought to originate from the bone marrow of a 36-month old boy with a metastatic adrenal stage-IV neuroblastoma. Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: COSMIC cell lines project. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00623. Population: Caucasian. Microsatellite instability: Stable (MSS) (Sanger). Omics: Genomics; DNA methylation analysis. Omics: Genomics; Whole exome sequencing. Omics: Phenotyping; Drug screening. Omics: Transcriptomics; Microarray. Omics: Variations; SNP array analysis. | ||||||||||||||||||||||||||||||||
| Sequence variations |
| ||||||||||||||||||||||||||||||||
| Genome ancestry | Source: PubMed=30894373
| ||||||||||||||||||||||||||||||||
| Disease | Melanoma (NCIt: C3224) | ||||||||||||||||||||||||||||||||
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||
| Hierarchy | Children:
| ||||||||||||||||||||||||||||||||
| Originate from same individual | CVCL_3962 ! LN-464 | ||||||||||||||||||||||||||||||||
| Sex of cell | Sex unspecified | ||||||||||||||||||||||||||||||||
| Age at sampling | Age unspecified | ||||||||||||||||||||||||||||||||
| Category | Cancer cell line | ||||||||||||||||||||||||||||||||
| STR profile | Source(s): Cosmic-CLP=906803; ICLC=HTL96020 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||
| Web pages | Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx | ||||||||||||||||||||||||||||||||
| Publications | PubMed=2467885; DOI=10.1002/ijc.2910430421 PubMed=1354203; DOI=10.1002/ijc.2910520116 PubMed=8509230; DOI=10.1002/ijc.2910540329 DOI=10.1007/0-306-46872-7_2 PubMed=15150552; DOI=10.1038/sj.bjc.6601842; PMCID=PMC2409504 PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675 | ||||||||||||||||||||||||||||||||
| Cross-references | |||||||||||||||||||||||||||||||||
| Cell line collections (Providers) | ICLC; HTL96020 | ||||||||||||||||||||||||||||||||
| Cell line databases/resources | CLO; CLO_0001655
CLDB; cl239 cancercelllines; CVCL_1068 Cell_Model_Passport; SIDM00057 Cosmic-CLP; 906803 DepMap; ACH-002389 LINCS_LDP; LCL-1982 | ||||||||||||||||||||||||||||||||
| Chemistry resources | ChEMBL-Cells; CHEMBL3308148
ChEMBL-Targets; CHEMBL2366195 GDSC; 906803 PharmacoDB; ACN_55_2019 PubChem_Cell_line; CVCL_1068 | ||||||||||||||||||||||||||||||||
| Encyclopedic resources | Wikidata; Q54608539 | ||||||||||||||||||||||||||||||||
| Gene expression databases | ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610 GEO; GSM1669594 | ||||||||||||||||||||||||||||||||
| Polymorphism and mutation databases | Cosmic; 906803
IARC_TP53; 21170 | ||||||||||||||||||||||||||||||||
| Sequence databases | EGA; EGAS00001000978 | ||||||||||||||||||||||||||||||||
| Entry history | |||||||||||||||||||||||||||||||||
| Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||
| Last entry update | 10-Apr-2025 | ||||||||||||||||||||||||||||||||
| Version number | 35 | ||||||||||||||||||||||||||||||||