Cellosaurus LN-464 (CVCL_3962)
Cell line name | LN-464 | ||||||||||||||||||||||||||||||||
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Synonyms | LN 464; LN464 | ||||||||||||||||||||||||||||||||
Accession | CVCL_3962 | ||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: LN-464 (RRID:CVCL_3962) | ||||||||||||||||||||||||||||||||
Comments | Problematic cell line: Contaminated. The STR profile of ACN and LN-464 are identical. SNP analysis (DepMap) also shows identity of both cell lines. Personal communication from Hegi M. confirms the mismatch between the STR profile of this cell line and of the patient from which LN-464 was established. We believe this is a melanoma cell line based on the RNASeq expression profile of LN-464 (DepMap) which clusters with that of melanoma patient samples. The presence of the BRAF V600E while present at low frequency in gliomas is also a hallmark of melanomas. Originally thought to originate from the brain right parieto-occipital lobe of a 67 year old male patient with a glioblastoma. Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Population: Caucasian. Doubling time: 35 hours (PubMed=25984343). Omics: Deep exome analysis. Omics: shRNA library screening. | ||||||||||||||||||||||||||||||||
Sequence variations |
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Disease | Melanoma (NCIt: C3224) | ||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||
Originate from same individual | CVCL_1068 ! ACN | ||||||||||||||||||||||||||||||||
Sex of cell | Sex unspecified | ||||||||||||||||||||||||||||||||
Age at sampling | Age unspecified | ||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||
STR profile | Source(s): PubMed=22570425 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||
Publications | PubMed=7693337 PubMed=8509230; DOI=10.1002/ijc.2910540329 PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x PubMed=22570425; DOI=10.1093/neuonc/nos072 PubMed=25984343; DOI=10.1038/sdata.2014.35 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 | ||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||
Cell line databases/resources | Cell_Model_Passport; SIDM00058
DepMap; ACH-000676 | ||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO:0004451 | ||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN10988403 | ||||||||||||||||||||||||||||||||
Chemistry resources | PharmacoDB; LN464_848_2019 | ||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q54902786 | ||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 849873
Cosmic; 2367498 Cosmic; 2516032 | ||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||
Last entry update | 21-Mar-2023 | ||||||||||||||||||||||||||||||||
Version number | 21 |